Chronic low grade inflammation in aging process as a link on a chain of obesity: Related vascular disorders

Vučević, Danijela; Radak, Đorđe; D, Dordević; Miletić, Maja; Jakovljević, Aleksandar; Jorgačević, Bojan; Vesković, Milena

doi:10.5937/medist1801032v

Cited by 2 publications

(1 citation statement)

References 76 publications

(214 reference statements)

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“…In addition, research in the field of molecular prevention is expected to lead to the discovery of new biomarkers, more accurate measurement of disease susceptibility (personalized risk assessment), as well as new knowledge about the effects of interactions related to gene-environment and especially food-genes [42,47]. In that way, the application of genomics in the population sciences would be useful both for the improvement of health status and for the prevention and treatment of diseases [42,48].…”

Section: Nutrigenetics and Nutrigenomicsmentioning

confidence: 99%

Unbalanced diet as a cardiometabolic risk factor

Vučević¹,

Samardžić²,

Radosavljević³

et al. 2022

Medicinska istraživanja

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A well-balanced diet is an important factor in the promotion and maintenance of good health throughout one's life. The role of a diet as a determinant of chronic non-communicable diseases is well established and it occupies a prominent position in prevention. The burden of chronic diseases is rapidly increasing worldwide. Namely, chronic non-communicable diseases are the leading cause of death worldwide. Preterm mortality in people under 70 accounts for over 40% of the total of 38 million deaths due to chronic non-communicable diseases. Obesity, metabolic syndrome, and diabetes mellitus are also showing worrying trends, not only because they already affect a large part of the population, but also because they have started to occur earlier in life. Thus, the metabolic syndrome is a cluster of more or less related metabolic and cardiovascular derangements including visceral obesity, insulin resistance, dyslipidemia, hypertension and glucose intolerance. This syndrome is characterized by a primary cellular defect in insulin action due to disorders in insulin signal transduction (insulin is unable to adequately achieve its biological effects). Under these conditions, insulin resistance, in combination with hyperinsulinemia causes numerous metabolic and cardiovascular disorders, which are leading causes of morbidity and mortality worldwide. From the pathophysiological point of view, a diet rich in carbohydrates and saturated fats significantly contributes to the development of many chronic diseases (diabetes mellitus type 2, hypertension, accelerated atherosclerosis and its cardiovascular and cerebrovascular complications, nonalcoholic fatty liver disease, polycystic ovary syndrome, and some malignant diseases - breast cancer, etc.). In this review, we provide an overview of recent literature data and practical knowledge related to an unbalanced diet as a cardiometabolic risk factor. Further investigations in the field of molecular prevention may contribute to the development of new biomarkers, or help the setting of strategies for molecular prevention of chronic non-communicable diseases. In other words, they represent the directive for applying nutrigenomics to population sciences.

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Section: Nutrigenetics and Nutrigenomicsmentioning

confidence: 99%

Unbalanced diet as a cardiometabolic risk factor

Vučević¹,

Samardžić²,

Radosavljević³

et al. 2022

Medicinska istraživanja

Self Cite

View full text Add to dashboard Cite

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Therapeutical Approach to Arterial Hypertension - Current State of the Art

Radosavljevic,

Vučević,

Samardžić

et al. 2024

CMC

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Arterial hypertension (AH) is recognized as the most common illness within the group of cardiovascular diseases and the most massive chronic non-infectious disease in the world. The number of hypertensive patients worldwide has reached 1.28 billion, contributing to an increase in cardiovascular diseases and premature death globally. The high prevalence of hypertension emphasizes the importance of effectively treating this condition. Elevated blood pressure often leads to lethal complications (heart failure, stroke, renal disorders, etc.) if left untreated. Considering an increase in AH prevalence in the future, a successful therapeutical approach to this disease and its complications is essential. The goal of AH treatment is to maintain normotensive blood pressure through various approaches, including lifestyle changes, a well-balanced diet, increased physical activity, psychoeducation, and, when necessary, pharmacotherapy. The evolving pharmacotherapeutic landscape reflects the progress made in our understanding of hypertension and emphasizes the need for continuous innovation to meet the challenges posed by this prevalent global health concern. The journey toward more effective and tailored treatments for hypertension is ongoing, and the introduction of new medications plays a pivotal role in shaping the future of antihypertensive pharmacotherapy.

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Chronic low grade inflammation in aging process as a link on a chain of obesity: Related vascular disorders

Cited by 2 publications

References 76 publications

Unbalanced diet as a cardiometabolic risk factor

Unbalanced diet as a cardiometabolic risk factor

Therapeutical Approach to Arterial Hypertension - Current State of the Art

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