The role of vascular and alveolar macrophages has become increasingly important in understanding the development of atherosclerosis and resulting pulmonary emphysema.
The pathogenesis of obesity-related vascular disorders has not been fully elucidated. The fundamental role of inflammation in aging process is now widely recognized, particularly for atherosclerotic disease which begins before birth. The number of obese individuals worldwide has reached two billion, leading to an explosion of obesity-related vascular disorders associated with increased morbidity and mortality. Obesity, as a chronic low grade inflammatory process, is important risk factor for metabolic and cardiovascular disease. Despite a well-known genetic component, this risk appears to originate from several abnormalities in adipose tissue function associated with a chronic inflammatory state. In particular, obesity as the most common nutritional disorder in industrialized countries, is closely related to impaired endothelial function, a well-known marker of preatherosclerotic disease. These conditions disrupt vascular homeostasis by causing an imbalance between the nitric oxide pathway and the endothelin-1 system, with impaired insulin-stimulated endothelium-dependent vasodilation. Having in mind the growing population of overweight and obese people worldwide, along with an increasingly aging population, understanding the pathophysiology of obesity on cardiovascular system is essential. The mechanisms linking obesity-related vascular disorders and low grade inflammation in aging process are the focus of this paper.
A well-balanced diet is an important factor in the promotion and maintenance of good health throughout one's life. The role of a diet as a determinant of chronic non-communicable diseases is well established and it occupies a prominent position in prevention. The burden of chronic diseases is rapidly increasing worldwide. Namely, chronic non-communicable diseases are the leading cause of death worldwide. Preterm mortality in people under 70 accounts for over 40% of the total of 38 million deaths due to chronic non-communicable diseases. Obesity, metabolic syndrome, and diabetes mellitus are also showing worrying trends, not only because they already affect a large part of the population, but also because they have started to occur earlier in life. Thus, the metabolic syndrome is a cluster of more or less related metabolic and cardiovascular derangements including visceral obesity, insulin resistance, dyslipidemia, hypertension and glucose intolerance. This syndrome is characterized by a primary cellular defect in insulin action due to disorders in insulin signal transduction (insulin is unable to adequately achieve its biological effects). Under these conditions, insulin resistance, in combination with hyperinsulinemia causes numerous metabolic and cardiovascular disorders, which are leading causes of morbidity and mortality worldwide. From the pathophysiological point of view, a diet rich in carbohydrates and saturated fats significantly contributes to the development of many chronic diseases (diabetes mellitus type 2, hypertension, accelerated atherosclerosis and its cardiovascular and cerebrovascular complications, nonalcoholic fatty liver disease, polycystic ovary syndrome, and some malignant diseases - breast cancer, etc.). In this review, we provide an overview of recent literature data and practical knowledge related to an unbalanced diet as a cardiometabolic risk factor. Further investigations in the field of molecular prevention may contribute to the development of new biomarkers, or help the setting of strategies for molecular prevention of chronic non-communicable diseases. In other words, they represent the directive for applying nutrigenomics to population sciences.
Protection from harmful effects of the magnetic/electromagnetic fields is still a great problem in many countries of modern society--huge costs, impaired quality of life, and more important, damage to the human health. Numerous data and publications of harmful effects of the magnetic/electromagnetic fields represents one's country basic necessary documentation for making decisions and law documents for protection norms on national level concerning the health maintenance according to the ICNIRP normatives.
Emeritus professor dr Andon G. Kostadinovic was born in a village called Donji Komren, nowadays already a suburban settlement of the town of Nis. His first contact with the scientific institution dr Andon Kostadinovic has established at the Higher Educational Institution in Nis, at the Department of French language and literature. After graduating at the above mentioned higher education institution he continues his studies at the Faculty of Philology and the Faculty of Philosophy in Belgrade at the Department of Sociology. Upon graduation at the Faculty of Philosophy he enrols at the postgraduate studies at the Faculty of Law and the Faculty of Political Sciences in Belgrade profiling for the Occupational Sociology as previously advised by professor dr Danilo Z. Markovic. He has defended his doctoral theses at the same faculty in the area of the Educational and Occupational Sociology. At the end of his working career to his always being distinguished and easily recognized for his achievements professor dr Andon G. Kostadinovic was elected a professor emeritus in 2017, at the University "Union Nikola Tesla" in Belgrade, Serbia, and then he starts up with his brother privately owned Faculty of Law, Security and Management "Constantine the Great" based in Nis, Serbia and becomes its Dean. This faculty is an integral part and unit of the University "Union Nikola Tesla" in Belgrade, Serbia. Today emeritus professor dr Andon G. Kostadinovic is a currently acting Vice Rector of the
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