The relationship between atherosclerosis and pulmonary emphysema

Vučević, Danijela; Radosavljević, Tatjana; D, Dordević; Mladenović, Dušan; Vesković, Milena

doi:10.2298/mpns1408231v

Cited by 5 publications

(13 citation statements)

References 16 publications

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“…The term endothelial dysfunction refers to a maladapted endothelial phenotype characterized by reduced nitric oxide (NO) bioavailability, increased oxidative stress, elevated expression of proinflammatory and prothrombotic factors, and abnormal vasoreactivity to endothelial-dependent stressor (32). Experimental and clinical data support a link between systemic inflammation and endothelial dysfunction (21,25,30,32,33). Moreover, endothelial dysfunction has increasingly been recognized to play an important role in a number of conditions associated with a high prevalence of atherosclerotic CVD (21,25,30).…”

Section: Inflammatory Response Of the Vessel Wall In Obesitymentioning

confidence: 99%

“…In an experimental model of atherosclerosis induced by a high-cholesterol diet, monocytes are first cell adjacent to the endothelium. Then they migrate into the subendothelial space, swallow the oxidized cholesterol, and transform it into foam cells (33). Hypercholesterolemia associated with elevated levels of atherogenic lipoproteins (low density lipoprotein /LDL/ and very low density lipoprotein /VLDL/) in the blood, leads to chronic presence of LDL in the arterial wall (21).…”

Section: Foam Cellsmentioning

confidence: 99%

“…It is known that local cytokine secretion and modification of native lipoprotein particles, that are internalized by vascular macrophages via the scavenger receptors class A (SRA) on the surfaces of these cells, lead to the formation of foam cells. Thus, exacerbation of local inflammatory process in the vascular tissue, due to generation of ROS, resulting in further lipoprotein modification and cytokine production (33). It has been shown that mononuclear phagocytic blood cells take part in the phagocytosis of native particles to a lesser extent, and of modified LDL particles to a greater extent after their binding to the SRA.…”

Section: Foam Cellsmentioning

confidence: 99%

“…Other proatherogenic effects of oxLDL particles, referring to endothelial cells, include expression of growth factors affecting smooth muscle cells, generation of superoxide anion (O 2 ), and endothelial cells apoptosis (38). The human endothelial receptor that mediates uptake of oxLDL belongs to C type lecitin family and is referred to as LOX-1 (lecitin-like oxLDL receptor-1) (33). Foam cell formation is also induced by receptors involved in oxLDL uptake (CD34, macrosialin/ CD68 /) and HDL receptor, which is referred to as SB-1 (33).…”

Section: Foam Cellsmentioning

confidence: 99%

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Chronic low grade inflammation in aging process as a link on a chain of obesity: Related vascular disorders

Vučević¹,

Radak²,

D³

et al. 2018

Medicinska istraživanja

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The pathogenesis of obesity-related vascular disorders has not been fully elucidated. The fundamental role of inflammation in aging process is now widely recognized, particularly for atherosclerotic disease which begins before birth. The number of obese individuals worldwide has reached two billion, leading to an explosion of obesity-related vascular disorders associated with increased morbidity and mortality. Obesity, as a chronic low grade inflammatory process, is important risk factor for metabolic and cardiovascular disease. Despite a well-known genetic component, this risk appears to originate from several abnormalities in adipose tissue function associated with a chronic inflammatory state. In particular, obesity as the most common nutritional disorder in industrialized countries, is closely related to impaired endothelial function, a well-known marker of preatherosclerotic disease. These conditions disrupt vascular homeostasis by causing an imbalance between the nitric oxide pathway and the endothelin-1 system, with impaired insulin-stimulated endothelium-dependent vasodilation. Having in mind the growing population of overweight and obese people worldwide, along with an increasingly aging population, understanding the pathophysiology of obesity on cardiovascular system is essential. The mechanisms linking obesity-related vascular disorders and low grade inflammation in aging process are the focus of this paper.

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Section: Inflammatory Response Of the Vessel Wall In Obesitymentioning

confidence: 99%

Section: Foam Cellsmentioning

confidence: 99%

Section: Foam Cellsmentioning

confidence: 99%

Section: Foam Cellsmentioning

confidence: 99%

See 2 more Smart Citations

Chronic low grade inflammation in aging process as a link on a chain of obesity: Related vascular disorders

Vučević¹,

Radak²,

D³

et al. 2018

Medicinska istraživanja

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“…chronic obstructive pulmonary disease; cardiovascular disease; mouse models PATIENTS WITH CHRONIC OBSTRUCTIVE pulmonary disease (COPD) have an increased risk for developing cardiovascular disease (CVD) (29,163), even after correction for common risk factors (145,193,194). Airflow limitation and emphysema are associated with arterial stiffness (29,233), and impaired lung function is correlated with cardiovascular morbidity (4), indicating an association between the severity of COPD and CVD. Exposure to cigarette smoke (CS) is the most important risk factor for COPD.…”

mentioning

confidence: 99%

Murine models of cardiovascular comorbidity in chronic obstructive pulmonary disease

Khedoe

Rensen

Berbée

et al. 2016

American Journal of Physiology-Lung Cellular and Molecular Phys

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Patients with chronic obstructive pulmonary disease (COPD) have an increased risk for cardiovascular disease (CVD). Currently, COPD patients with atherosclerosis (i.e., the most important underlying cause of CVD) receive COPD therapy complemented with standard CVD therapy. This may, however, not be the most optimal treatment. To investigate the link between COPD and atherosclerosis and to develop specific therapeutic strategies for COPD patients with atherosclerosis, a substantial number of preclinical studies using murine models have been performed. In this review, we summarize the currently used murine models of COPD and atherosclerosis, both individually and combined, and discuss the relevance of these models for studying the pathogenesis and development of new treatments for COPD patients with atherosclerosis. Murine and clinical studies have provided complementary information showing a prominent role for systemic inflammation and oxidative stress in the link between COPD and atherosclerosis. These and other studies showed that murine models for COPD and atherosclerosis are useful tools and can provide important insights relevant to understanding the link between COPD and CVD. More importantly, murine studies provide good platforms for studying the potential of promising (new) therapeutic strategies for COPD patients with CVD.

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Recent Approaches and Future Perspectives on Elastin Regeneration and Repair

Joshi¹,

Kothapalli²

2016

Elastic Fiber Matrices

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The relationship between atherosclerosis and pulmonary emphysema

Abstract: The role of vascular and alveolar macrophages has become increasingly important in understanding the development of atherosclerosis and resulting pulmonary emphysema.

Cited by 5 publications

References 16 publications

Chronic low grade inflammation in aging process as a link on a chain of obesity: Related vascular disorders

Chronic low grade inflammation in aging process as a link on a chain of obesity: Related vascular disorders

Murine models of cardiovascular comorbidity in chronic obstructive pulmonary disease

Recent Approaches and Future Perspectives on Elastin Regeneration and Repair

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