Chronic lymphocytic leukemia: interplay between noncoding RNAs and protein-coding genes

Calin, George A.; Croce, Carlo M.

doi:10.1182/blood-2009-07-192740

Cited by 99 publications

(95 citation statements)

References 90 publications

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“…MiRNAs act post-transcriptionally within cells to regulate gene expression by binding to target messenger RNAs (mRNAs), causing either translation repression or cleavage of target transcripts. 38 Using bioinformatic analysis, Katzaki et al found that 4 out of 9 patients with overlapping deletions of 21q22 had a deletion of the miRNA miR-802. 34 However, 2 of the patients who developed MDS/AML were included in the analysis and both retained expression of miR-802.…”

Section: Syndromic Cases Of Loss Of Chromosome 21q22mentioning

confidence: 99%

Familial myelodysplastic syndromes: a review of the literature

2011

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Section: Syndromic Cases Of Loss Of Chromosome 21q22mentioning

confidence: 99%

Familial myelodysplastic syndromes: a review of the literature

2011

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“…A generally accepted sequence of steps for the biochemical processing of precursor miRNA to the mature forms is known as the ''linear" canonical pathway (Winter et al, 2009). MiRNAs have been found to play particular important roles in cell differentiation by negatively regulating translation (Calin & Croce, 2009;Iorio & Croce, 2009;Lim et al, 2005;Liu & Olson, 2010). miRNAs bind to specific 3'UTR sequences of mRNAs and thereby prevent efficient translation or mediate degradation of target mRNAs.…”

Section: Microrna-21 (Mir-21)mentioning

confidence: 99%

Molecular Traits of the Budding Colorectal Cancer Cells

Nielsen¹

2012

Colorectal Cancer Biology - From Genes to Tumor

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“…Recently, several studies have revealed a critical role for microRNAs (miRNAs) during tumorigenesis and metastasis of several cancers, including MB. [3][4][5][6] Besides intracellular miRNAs with the traditional function of translation regulation, there is accumulating evidence that miRNAs exist extracellularly in body fl uids, including cerebrospinal fl uids (CSF). [7,8] Several reports have described that deregulated extracellular-miRNAs (ex-miRNAs) are closely associated with the clinical course of malignant tumors.…”

Section: Introductionmentioning

confidence: 99%

Detection and quantification of extracellular microRNAs in medulloblastoma

Shalaby¹,

Fiaschetti²,

Baulande³

et al. 2015

J Cancer Metastasis Treat

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Aim: Medu lloblastoma (MB) is the most common malignant brain tumor in children. The crucial role of extracellular-microRNAs (ex-miRNAs) in cancer has been widely recognized; however, their role in MB remains unknown. This study aimed to investigate MB-driven ex-miRNAs. Methods: Microarray analysis was used to disclose the identity and quantity of key miRNAs excreted in culture-medium (CM) of 3 human MB cell lines and cere brospinal fl uid (CSF) of brain tumors (including MB) and leukemia patients. MiRNA expression was validated by quantitative reverse transcription polymerase chain reaction. Results: We have demonstrated that the 3 MB cell lines tested commonly expressed 1,083 miRNAs in their spent CM. Among them, 57 miRNAs were specifi c to the CM of metastasis-related cell lines which represents the aggressive group 3 and group 4 MB subtypes. A signifi cant number (1,254) of ex-miRNAs were identifi ed in the CSF of a MB patient. Eighty-six of these miRNAs were found to be differentially expressed in this patient's CSF compared with controls. Interestingly, 3 metastasis-associated miRNAs over-represented in CM of metastasis-related MB cell lines were found to be signifi cantly enriched in the CSF of the MB patient. Conclusion: Although more samples are required to fully verify these results, our work provides the fi rst evidence for the presence of a signifi cant amount of miRNAs excreted extracellularly by MB cells and raises the possibility that, in the near future, miRNAs could be probed in CSF of MB patients and serve as novel biological markers.

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Chronic lymphocytic leukemia: interplay between noncoding RNAs and protein-coding genes

Abstract: One of the most unexpected and fascinating discoveries in oncology over the past few years is the interplay between abnormalities in protein-coding genes and noncoding RNAs (ncRNAs) that is causally involved in cancer initiation, progression, and dissemination. MicroRNAs (

Cited by 99 publications

References 90 publications

Familial myelodysplastic syndromes: a review of the literature

Familial myelodysplastic syndromes: a review of the literature

Molecular Traits of the Budding Colorectal Cancer Cells

Detection and quantification of extracellular microRNAs in medulloblastoma

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