Chronic lymphoproliterative disorder with unusual clinical, morphologic, ultrastructural and membrane surface marker characteristics

McKenna, Robert W.; Parkin, Janet L.; Kersey, John H.; Gajl‐Peczalska, Kazimiera J.; Peterson, Lo Ann C.; Brunning, Richard D.

doi:10.1016/0002-9343(77)90422-3

Cited by 188 publications

(63 citation statements)

References 17 publications

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“…3 In 1985, the term 'LGL leukemia' was first coined for a clonal disorder involving T-LGLs. 4 In 1989, the French-American-British (FAB) classification proposed to list this disorder as one of four 'chronic (mature) T cell leukemias', however under the designation 'T-CLL (chronic lymphocytic leukemia)'.…”

Section: Lgl Cells and Lgl Leukemiasmentioning

confidence: 99%

Malignant hematopoietic cell lines: in vitro models for the study of natural killer cell leukemia–lymphoma

Drexler

Matsuo

2000

Leukemia

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Section: Lgl Cells and Lgl Leukemiasmentioning

confidence: 99%

Malignant hematopoietic cell lines: in vitro models for the study of natural killer cell leukemia–lymphoma

Drexler

Matsuo

2000

Leukemia

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“…1 Some healthy individuals may have small circulating CD8 + T cells compatible with large granular lymphocytes (LGL) and expressing the CD57 glycoprotein determinant. 2 LGL can be either oligoclonal or polyclonal, 3 and can arise from a CD3 + T cell lineage or from CD3 − NK cell lineage.…”

Section: Introductionmentioning

confidence: 99%

Features of large granular lymphocytes (LGL) expansion following allogeneic stem cell transplantation: a long-term analysis

et al. 2002

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Large granular lymphocyte (LGL) proliferation typically follows a chronic course during which major features are cytopenia and immune abnormalities. Elevated numbers of LGL were reported in a few cases following allogeneic stem cell transplantation (allo-SCT). In this report, we present a retrospective analysis of LGL cases that occurred following allo-SCT in a cohort of 201 consecutive patients transplanted over a period of 7 years. Six cases were identified and LGL expansion occurred more frequently following a reduced fludarabine and anti-T lymphocyte globulin-based preparative regimen (4 cases/49), than after a conventional myeloablative regimen (2 cases/152). Expansion of LGL was seen between 3 and 15 months following allo-SCT. Hematopoiesis, with mild to severe cytopenia, was a favored target for LGL. Autoimmune manifestations including polyarthritis and hypergammaglobulinemia were also observed. LGL proliferation was observed in the context of chronic antigenic stimulation associated with recurrent viral infections especially CMV. Moreover, five out of these six high risk patients achieved a long-term complete remission concomitant or following LGL expansion. These data suggest that LGL might be a subset of effector lymphocytes which may participate to the graft-versus-tumor effect.

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“…С момента первого описания в 1977г Т-ЛБГЛ имел разные названия: Т-хронический лимфолейкоз, Т8-гипер-лейкоцитоз, Т -лимфопролиферативное заболевание, Т-клеточный лимфоцитоз с нейтропенией [18]. В начале 90-х годов, после доказательства клональной природы этой бо лезни, Т-ЛБГЛ был выделен в отдельную нозологическую форму [14].…”

Section: уничтожение мишениunclassified

Neutropenia in rheumatoid arthritis and large granular lymphocyte leucosis

Doronin¹,

Nikitin²,

Sidorova³

et al. 2003

rsp

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Chronic lymphoproliterative disorder with unusual clinical, morphologic, ultrastructural and membrane surface marker characteristics

Cited by 188 publications

References 17 publications

Malignant hematopoietic cell lines: in vitro models for the study of natural killer cell leukemia–lymphoma

Malignant hematopoietic cell lines: in vitro models for the study of natural killer cell leukemia–lymphoma

Features of large granular lymphocytes (LGL) expansion following allogeneic stem cell transplantation: a long-term analysis

Neutropenia in rheumatoid arthritis and large granular lymphocyte leucosis

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