Chronic Meningococcemia

Infective Endocarditis and Other Intravascular Infections

“…(292,298,299) Skin rash is said to be absent in about 50% of patients with IE due to the meningococcus. (298) …”

Severe selective IgM deficiency.

“…Selective IgM deficiency is recognized as occurring in association with coeliac disease (Asquith et al, 1969) and other protein-losing enteropathies, acute and chronic meningococcal septicaemia (Hobbs et al, 1967a;Fass and Saslaw, 1972;Jones et al, 1973), in atopic individuals (Kaufman and Hobbs, 1970), and as a familial condition (Hobbs et al, 1967a;Jones et al, 1973). Serum IgM levels may be selectively depressed in the Wiskott-Aldrich syndrome and in the Giedion Scheidegger syndrome (Giedion and Scheidegger, 1957), and low levels have also been reported, as part of a complex immunological defect, in a family who suffered recurrent viral infections (Silver et al, 1973).…”