Chronic methamphetamine and its withdrawal modify behavioral and neuroendocrine circadian rhythms

Morimasa, Tadaomi; Wirz‐Justice, Anna; Kraeuchi, Kurt; Arendt, Joséphine; Baumann, J. M.; Haeusler, Albert; Degen, P.H.; Feer, H.

doi:10.1016/0031-9384(87)90253-8

Cited by 23 publications

(11 citation statements)

References 16 publications

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“…Acute METH injection significantly increased the level of CORT secretion in both strains, a result consistent with many reports indicating that the administration of psychostimulants activates the HPA axis [19,24,25]. Moreover, LE rats had a higher level of CORT at the baseline than WIS rats.…”

Section: Discussionsupporting

confidence: 77%

“…Recent research focused on stress which could be linked to its status of drug abuse. For example, psychostimulants themselves activate the function of the hypothalamic-pituitary-adrenal (HPA) axis [19,[23][24][25]. Alternatively, neurodevelopmental changes by stress exposure at an early stage of life could increase vulnerability to drug abuse [10].…”

Section: Introductionmentioning

confidence: 99%

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The Pharmacokinetic Properties of Methamphetamine in Rats with Previous Repeated Exposure to Methamphetamine: The Differences between Long-Evans and Wistar Rats

et al. 2007

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Section: Discussionsupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

The Pharmacokinetic Properties of Methamphetamine in Rats with Previous Repeated Exposure to Methamphetamine: The Differences between Long-Evans and Wistar Rats

et al. 2007

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“…Therefore, conventional neurotoxic markers used for adult animals appear to be unsatisfactory to demarcate the boundaries of the P11-20 critical period. Adult animals also demonstrate sympathetic activation and elevations in hormones of the hypothalamic-pituitaryadrenal (HPA) axis following MA administration (Morimasa et al 1987). Exposure to MA during the neonatal period produces similar changes in the hormones of the HPA axis (Williams et al 2000).…”

Section: Introductionmentioning

confidence: 97%

Refining the critical period for methamphetamine-induced spatial deficits in the Morris water maze

Williams

Moran

2003

Psychopharmacology

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Rationale: Neonatal administration of methamphetamine (MA) to rats from postnatal day (P) 11 to 20, but not from P1 to P10, produces lasting deficits in spatial learning and memory. The preweaning period of development in the rat corresponds to human third trimester hippocampal development and because of the increased use of MA in women of childbearing age, there is a greater likelihood that fetuses will be exposed to this drug. Development of the hippocampus is dependent upon many factors, including an optimal level of corticosterone (CORT). We have demonstrated that the CORT response of animals on P11 to MA is protracted relative to administration on P15 or P20. Interestingly, the P11 animals are still in the stress hyporesponsive period. Objectives: We postulated that because of the prolonged CORT response on P11, the effects of MA on spatial learning and memory may be confined to a shorter period of exposure. Methods: Neonatal rats were administered MA (10 mg/kg) 4 times daily from either P11 to P15 or from P16 to P20, raised to adulthood and tested against animals only administered saline (SAL) from P11 to P20 for anxiety, swimming ability, and spatial learning and memory. Results: Animals exposed to MA, regardless of exposure period, tended to be less anxious in the Zero maze relative to SAL animals. No differences were noted for swimming ability. Only animals exposed to MA from P11 to P15 demonstrated deficits in spatial learning and memory during acquisition as well as during a shifted platform phase where learning a new position was required. Conclusions: The results demonstrate that spatial learning and memory deficits produced by MA administration are dependent upon when the exposure of the animal occurs and appears to be during the period of development in the rat when the response to threatening environments, stressors, is greatly reduced.

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“…Similar rhythms can also be induced in SCNX rats when MAP is administered via osmotic pumps instead of drinking water (Honma, Honma et al 1987). In SCNX rats, chronic MAP also induces circadian rhythms of body temperature, drinking, feeding, total activity and corticosterone (Morimasa, Wirz-Justice et al 1987;Rietveld, Korving et al 1987;Honma, Honma et al 1988;Ruis, Buys et al 1990;Hiroshige, Honma et al 1991). These rhythms seem to preserve their normal phase relationships with the locomotor activity rhythm during the MAP treatment.…”

Section: Effects Of Map On Circadian Behavior (And Other) Rhythmsmentioning

confidence: 88%

“…Chronic MAP produces rhythmicity in arrhythmic Clock m1Jt mutant mice in constant darkness (DD) (Masubuchi, Honma et al 2001). Chronic MAP also induces circadian rhythms of body temperature, drinking, feeding, total activity and corticosterone (Morimasa, Wirz-Justice et al 1987;Rietveld, Korving et al 1987;Honma, Honma et al 1988;Ruis, Buys et al 1990;Hiroshige, Honma et al 1991). These data demonstrate that the MASCO is anatomically distinct from the SCN.…”

Section: Introductionmentioning

confidence: 99%

Effects of Methamphetamine on Circadian Rhythms of Mice

Tataroglu

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The circadian system allows an organism to anticipate rhythmic changes in the external conditions and thereby increases its fitness. In rodents, the circadian clock resides in a pair of nuclei called the suprachiasmatic nuclei (SCN) which regulates rhythms of locomotor behavior, body temperature and some other physiological variables. However, this hierarchical organization of the circadian system is challenged by the discovery of two SCN-independent major oscillators; a feeding-entrainable oscillator (FEO) and a methamphetamine-sensitive circadian oscillator (MASCO). The presence of SCN, FEO and MASCO suggests a central multi-oscillatory organization of the circadian system in rodents, similar to the organization found in non-mammal vertebrates. At present, we know very little about how this complex multi-oscillator system is integrated.Although there is substantial information available about the SCN, the molecular components, localization and natural role of MASCO in the body are unknown. In fact, it is still debated whether MASCO is a bona fide circadian oscillator rather than a simple hourglass mechanism. This is largely due to the lack of a robust circadian model to study the effects of methamphetamine (MAP) on circadian rhythms. This thesis aims to fill some of these gaps in our understanding of this fascinating major oscillator 3 Using mice, we successfully replicated the published effects of chronic MAP on the circadian rhythms of rats. In fact, the differences such as more robust and clear activity rhythms, more pronounced MAP-induced second components of the rhythm and obvious sex and strain differences make the mice a better model.The results also indicated that MASCO interacts with the SCN in a manner that is strain, sex and dose dependent. Our experiments testing the hourglass explanation showed that the effects of MAP can not be explained by such a mechanism. This suggests that MASCO has circadian properties and is indeed a bona fide circadian clock. We also tried to elucidate the similarities between the molecular components of SCN and MASCO using several circadian mutant mice that were available to us. Although, the results of these experiments are not adequate to propose a list of known circadian genes that are involved in MASCO function, they provide the background for future studies that will determine the differences between the molecular components of SCN and MASCO.Utilization of the mouse strains presented in this thesis will provide an easy to obtain standard model where MASCO can be studied using latest developments in genetics and molecular biology. Identification of the natural role of MASCO in the body and its interactions with other oscillators in the body is of both scientific and clinical significance and will greatly improve our understanding of the circadian system in mammals.4 Acknowledgements I would like to thank Dr.Menaker for his continuous support and outstanding mentoring. I owe whatever I accomplished during my time at UVA to him and could never repay my debt. I a...

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Chronic methamphetamine and its withdrawal modify behavioral and neuroendocrine circadian rhythms

Cited by 23 publications

References 16 publications

The Pharmacokinetic Properties of Methamphetamine in Rats with Previous Repeated Exposure to Methamphetamine: The Differences between Long-Evans and Wistar Rats

The Pharmacokinetic Properties of Methamphetamine in Rats with Previous Repeated Exposure to Methamphetamine: The Differences between Long-Evans and Wistar Rats

Refining the critical period for methamphetamine-induced spatial deficits in the Morris water maze

Effects of Methamphetamine on Circadian Rhythms of Mice

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