Chronic myelogenous leukemia occurring in two brothers diagnosed 26 years apart

Lessen, David; Novoselac, Amory V.; Hellman, Gerard C.; Tapia, Alberto Rubio; Ratner, L.; Najfeld, Vesna

doi:10.1016/j.cancergencyto.2004.11.013

Cited by 7 publications

(5 citation statements)

References 16 publications

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“…Reports of other risk factors have been largely inconsistent and include long‐term exposure to organic solvents, pesticides and extreme low frequency electromagnetic fields [Bjork et al, 2001; Van Maele‐Fabry et al, 2007]. Although rare reports of familial occurrences exist, a heritable component has not yet been substantiated [Lessen et al, 2005]. Our finding of a possible association between benzene and CML provides support for a possible environmental component in the development of CML.…”

Section: Discussionmentioning

confidence: 99%

Elevated mRNA levels of DNA methyltransferase‐1 as an independent prognostic factor in primary nonsmall cell lung cancer

Kim

Kwon

Kim

et al. 2006

Cancer

104

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Objective We documented previously that if study quality is accounted for, evidence from occupational cohort studies on benzene supports a possible association with some lymphoma subtypes, in particular multiple myeloma, and acute and chronic lymphocytic leukemia. Here, we extend these analyses to chronic myeloid leukemia (CML). Methods Three strategies to assess study quality (stratification by the year‐of‐start of follow‐up, stratification by the strength of the reported acute myeloid leukemia (AML) association, and stratification by the quality of benzene exposure assessment) were employed in a meta‐analysis of occupational benzene exposure and CML. We hypothesized that stratification by these study quality dimensions would identify a subgroup of occupational cohort studies that is most informative for the evaluation of the possible association between benzene and CML. Results The overall meta‐relative risk (mRR) was non‐significantly elevated (1.23; 95% confidence interval (CI): 0.93–1.63). The mRRs increased with increasing study quality for all dimensions with a significant elevation for studies with start of follow‐up after 1970 (1.67; 95% CI: 1.02–2.74). The highest study quality stratum for AML significance and exposure quality showed an elevated but non‐significant increased mRR (1.40; 95% CI: 0.86–2.27, and 1.68; 95% CI: 0.74–3.84, respectively). Conclusions Although limited by low statistical power, the current meta‐analysis provides support for a possible association of occupational exposure to benzene and the risk of CML. Am. J. Ind. Med. 55:779–785, 2012. © 2012 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Elevated mRNA levels of DNA methyltransferase‐1 as an independent prognostic factor in primary nonsmall cell lung cancer

Kim

Kwon

Kim

et al. 2006

Cancer

104

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“…Multiple studies have reported crossgeneration and sibling-related cases (Lessen et al, 2005). For example, two identical twins and a brother were diagnosed at age 64, 64 and 68, respectively, with Philadelphia chromosome (Ph) þ CML (Tokuhata et al, 1968).…”

Section: Additional Factorsmentioning

confidence: 99%

Fusion tyrosine kinases: a result and cause of genomic instability

Penserga

Skórski

2006

Oncogene

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“…An interesting case of two brothers diagnosed with CML 26 years apart was reported by Lessen et al in 2005 [7] . A 45-year-old man was diagnosed in 2003 suffering from CML by conventional cytogenetics and I-FISH analysis confirmed the presence of BCR-ABL gene.…”

mentioning

confidence: 92%

Chronic myelogenous leukemia occurring in two brothers: The opposite sides of the same coin?

Verrou

Tsirou

Karampatzakis

et al. 2021

Leukemia Research Reports

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Herein we present a rare case of two brothers diagnosed with CML four years apart. Importantly, our case of CML occurrence among siblings is the fifth one reported and the second one investigated by both, conventional cytogenetics and RT-PCR analysis. Moreover, although Ph chromosome was detected in both our patients, RT-PCR revealed the presence of two different BCR-ABL transcripts. Finally, both our patients have been followed for a long period of time offering thus the opportunity to observe the differences in the clinical course.

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Chronic myelogenous leukemia occurring in two brothers diagnosed 26 years apart

Cited by 7 publications

References 16 publications

Elevated mRNA levels of DNA methyltransferase‐1 as an independent prognostic factor in primary nonsmall cell lung cancer

Elevated mRNA levels of DNA methyltransferase‐1 as an independent prognostic factor in primary nonsmall cell lung cancer

Fusion tyrosine kinases: a result and cause of genomic instability

Chronic myelogenous leukemia occurring in two brothers: The opposite sides of the same coin?

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