Chronic natural arsenic exposure affecting histoarchitecture of gonads in Black Bengal goats (Capra aegagrushircus)

Wares, Md. Abdul; Awal, Md. Abdul; Das, Shonkor Kumar; Hannan, Md. Abdul; Anas, Md. Abu; Latif, Mohammad Abdul; Masud, Neshat

doi:10.5455/javar.2015.b61

Cited by 10 publications

(7 citation statements)

References 13 publications

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“…Vacuolar degeneration in the seminiferous tubules was also present with absence of active spermatogenesis. Similar histological changes following arsenic treatment have been reported in rats (Fouad, Albuali, & Jresat, ; Momeni, Oryan, & Eskandar, ; Sarkar et al., ) as well as in Black Bengal male goats exposed to arsenic naturally due to environmental pollution (Awal et al., ; Wares et al., ). The depletion of germ cells and shrinkage of seminiferous tubules with necrotic changes have also been reported in rats given arsenic treatment (Mukherjee & Mukhopadhyay, ; Sharma & Kumar, ).…”

Section: Discussionsupporting

confidence: 75%

“…The mass of testes is an important index of reproductive toxicants (Aman, ), and reduction in mass of testes may be due to elimination of germ cells (Chapin & Lamb, ). However, no significant difference was reported in the mean values of weight, length, width and breadth of both testes as well the epididymis and ductus deferens in naturally arsenic‐affected goats (Wares, Awal, Nasrin, & Siddiqi, ; Wares et al., ). This difference might be due to relatively low doses of arsenic during natural exposure.…”

Section: Discussionmentioning

confidence: 99%

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Protective effects of vitamin E on sodium arsenite-induced toxicity, testicular measurements and histopathological studies of testes in Teddy goat bucks

et al. 2016

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The objective of this study was to investigate the toxic effects of arsenic on testicular measurements and histology of adult Teddy goats bucks and to examine whether these toxic effects are scavenged by vitamin E. Twelve adult Teddy goat bucks were divided randomly into three groups, A, B and C. Group A was kept as control, the B was given sodium arsenite 5 mg/kg BW per day, and group C was fed with vitamin E 200 mg/kg BW per day + arsenic 5 mg/kg BW per day. This treatment was continued for 84 days. Analysis of data revealed that the testicular measurements (scrotal circumference, width, length and weight) were significantly reduced in arsenic-treated animals, whereas there were ameliorating effects of vitamin E on these parameters. The major histopathological changes were present in the form of loss of germinal epithelium, atrophy of Leydig cells and vacuolations. Vitamin E in combination with sodium arsenite increased the active spermatogenesis as well as restoration of germinal epithelium. It can be concluded from the present findings that sodium arsenite causes toxicity in the male reproductive system of Teddy goat bucks with major changes in parenchyma of testes. Supplementation of vitamin E has protective effects on the toxicity of sodium arsenite on the reproductive system of male Teddy goat bucks.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Protective effects of vitamin E on sodium arsenite-induced toxicity, testicular measurements and histopathological studies of testes in Teddy goat bucks

et al. 2016

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“…The mass of testes is known as important index of the toxic attacks in male animals (Aman, ). The male gonads are affected by arsenic intoxication (Veeramachaneni, ; Wares et al., ). The male rats were treated with sodium arsenite at 40 ppm for 28 days (Khan et al., ).…”

Section: Effect Of Arsenic On Biometry Of Testesmentioning

confidence: 99%

“…() reported that sodium arsenite causes the reduction in the weight of testes due to degeneration of germ cells in rats. There was insignificant effect of arsenic on the length, width and weight of testes during the natural exposure of arsenic in Black Bengal goats (Wares et al., ).…”

Section: Effect Of Arsenic On Biometry Of Testesmentioning

confidence: 99%

Review on arsenic-induced toxicity in male reproductive system and its amelioration

2017

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Arsenic is an environmental toxicant which causes mutagenic, teratogenic and carcinogenic defects. It is used as herbicide, fungicide and rodenticide and results in contamination of air, soil and water. Arsenic is also produced through burning of coal industries. The sludge of factories contaminates the fodder and drinking source of water of human and livestock. Arsenic binds thiol groups in tissue proteins and impairs the function of the proteins. This metal affects the mitochondrial enzymes and interrupts the production of energy. Oxidative stress and the generation of reactive oxygen species could also be a consequence of arsenic exposure. High arsenic level may suppress the sensitivity of gonadotroph cells to GnRH as well as gonadotropin secretion by elevating plasma levels of glucocorticoids. These ultimately lead to the development of gonad toxicity in animals and cause the reduction in sperm number, sperm viability and motility. Massive degeneration of germ cells and alterations in the level of LH, FSH and testosterone are also reported. The objective of this review was to find out the effects of arsenic-induced toxicity on male reproductive system in animals and its amelioration.

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“…This procedure demonstrates pretty well every practical histopathologic with additional diagnostic studies such as histological examination in microscopy scission. [18][19][20] …”

Section: Histological Treatmentmentioning

confidence: 99%

Arsenic Status and Speciation in Chicken Heart Tissues

Pizarro

Román

Gómez

et al. 2015

J. Chil. Chem. Soc.

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SUMMARYThis study evaluated the total and main arsenic species in chicken heart tissues. The experimental study was carried out using two sets of samples. In the first one, 30-day-old chickens were exposed to sodium arsenate, using spiked drinking water. These chickens grew normally and were killed after fifty days of arsenic exposure. The second sets were edible chickens were nonexposed to sodium arsenate for a parallel study. The total arsenic and arsenic species content in the exposed samples were at least twice those in the normal edible chicken. One important aspect is the capability of the heart tissues to preconcentrate the most toxic species, arsenite, in the exposed chicken. Arsenobetaine was also detected in fat in the non exposed chicken.This study could be a way of establishing similarities and differences with humans exposed to the same As(V) species, to ascertain whether chickens can be used in arsenic metabolism evaluation and the results extrapolated to humans.

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Chronic natural arsenic exposure affecting histoarchitecture of gonads in Black Bengal goats (Capra aegagrushircus)

Cited by 10 publications

References 13 publications

Protective effects of vitamin E on sodium arsenite-induced toxicity, testicular measurements and histopathological studies of testes in Teddy goat bucks

Protective effects of vitamin E on sodium arsenite-induced toxicity, testicular measurements and histopathological studies of testes in Teddy goat bucks

Review on arsenic-induced toxicity in male reproductive system and its amelioration

Arsenic Status and Speciation in Chicken Heart Tissues

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