Chronic Obstructive Pulmonary Disease: Lobar Analysis with Hyperpolarized ¹²⁹Xe MR Imaging

Abstract

Purpose:To compare lobar ventilation and apparent diffusion coefficient (ADC) values obtained with hyperpolarized xenon 129 ( 129 Xe) magnetic resonance (MR) imaging to quantitative computed tomography (CT) metrics on a lobar basis and pulmonary function test (PFT) results on a wholelung basis in patients with chronic obstructive pulmonary disease (COPD). Materials andMethods:The study was approved by the National Research Ethics Service Committee; written informed consent was obtained from all patients. Results:Percentage ventilated volume and average ADC at lobar 129 Xe MR imaging showed correlation with percentage emphysema at lobar quantitative CT (r = 20.32, P , .001 and r = 0.75, P , .0001, respectively). The average ADC at whole-lung 129 Xe MR imaging showed moderate correlation with PFT results (percentage predicted transfer factor of the lung for carbon monoxide [Tlco]: r = 20.61, P , .005) and percentage predicted functional residual capacity (r = 0.47, P , .05). Whole-lung quantitative CT percentage emphysema also showed statistically significant correlation with percentage predicted Tlco (r = 20.65, P , .005). Conclusion:Lobar ventilation and ADC values obtained from hyperpolarized 129Xe MR imaging demonstrated correlation with quantitative CT percentage emphysema on a lobar basis and with PFT results on a whole-lung basis.q RSNA, 2016

Fast dynamic ventilation MRI of hyperpolarized 129Xe using spiral imaging

“…Spiral trajectories were designed to achieve an optimal spatial resolution and signal-to-noise ratio (SNR) for each interleave strategy within the limits of clinical slew rates of 200 T/m/s and a gradient amplitude of 50 mT/m. The T read per interleaf and the pixel resolutions are shown in Table 1 for 1-interleaf, 2-interleaf, 4-interleaf, and 8-interleaf spirals (i.e., N int ¼ 1, 2,4,8). This choice of spiral interleaved strategy resulted in comparable T Ã 2 blurring artefacts (<$10% of the available spatial resolution) per interleaf.…”

“…Functional pulmonary imaging techniques including hyperpolarized (HP) gas ( 3 He and 129 Xe) MRI are a growing field for the non-invasive assessment of regional lung function (1)(2)(3)(4). Hyperpolarized gas MRI enables the evaluation of ventilation and gas diffusion, which is typically carried out in a static imaging fashion during a breath-hold interval, following inhalation of 3 He or 129 Xe, and demonstrates homogeneous signal intensity in healthy lung regions (5)(6)(7)(8).…”

A protocol for quantifying cardiogenic oscillations in dynamic 129Xe gas exchange spectroscopy: The effects of idiopathic pulmonary fibrosis

“…Hyperpolarized 129 Xe MRI is emerging as a valuable means of imaging lung structure and function. 1,2 Arguably, its most significant feature as a probe for lung function is enabled by its solubility in blood and biological tissues, combined with distinct in vivo chemical shifts that reflect the local environment. 3 Recent years have seen significant efforts to both characterize and exploit these unique properties to gain insights into cardiopulmonary physiology and pathophysiology.…”

Quantitative evaluation of lung injury caused by PM2.5 using hyperpolarized gas magnetic resonance

“…Hyperpolarized 129 Xe MR has been proven to be a powerful tool to evaluate the pulmonary function and microstructure attributed to its extremely high MR sensitivity . As a noninvasive, ionizing radiation‐free technique, hyperpolarized 129 Xe MR enables quantifying the changes in pulmonary ventilation, microstructure, and gas exchange function, which have been widely used to study various lung diseases.…”