Chronic oral administration of pine bark extract (flavangenol) attenuates brain and liver mRNA expressions of HSPs in heat-exposed chicks

Yang, Hui; Chowdhury, Vishwajit S.; Bahry, Mohammad A.; Tran, Phuong V.; Phong, H.; Han, Guofeng; Zhang, Rong; Tagashira, Hideki; Tsubata, Masahito; Furuse, Mitsuhiro

doi:10.1016/j.jtherbio.2016.06.014

Cited by 12 publications

(3 citation statements)

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“…The results were in agreement with previous studies in which curcumin, a natural botanical polyphenol, reduced the mRNA levels of HSP70 and HSP90 in the breast muscle and liver of heat‐treated birds . Similarly, chronic oral administration of flavangenol (pine‐bark extract), which is an excellent antioxidant because polyphenol is one of its major constituents, attenuated HSP70 and HSP90 mRNA expression in the livers of heat‐stressed broilers . AvUCP is involved in thermogenesis and the regulation of mitochondrial ROS production .…”

Section: Discussionsupporting

confidence: 91%

Dietary enzymatically treated Artemisia annua L. improves meat quality, antioxidant capacity and energy status of breast muscle in heat‐stressed broilers

et al. 2018

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Section: Discussionsupporting

confidence: 91%

Dietary enzymatically treated Artemisia annua L. improves meat quality, antioxidant capacity and energy status of breast muscle in heat‐stressed broilers

et al. 2018

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“…In addition, heat shock proteins assist immature protein processing and folding and play a role in regulating apoptosis [63]. However, when effective interventions reduce the effects of external stimuli, heat shock protein expression decreases [64]. The expression levels of Hsp70 and Hsp90 increase rapidly when heat stress occurs, and the heat stress intervention using polyphenols can reduce the expression levels of Hsp70 and Hsp90 [14,65].…”

Section: Vitexin Inhibited Apoptosis By Regulating Heat Shock Protein...mentioning

confidence: 99%

Vitexin Regulates Heat Shock Protein Expression by Modulating ROS Levels Thereby Protecting against Heat-Stress-Induced Apoptosis

Wu,

Sheng,

Tian

et al. 2023

Molecules

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Heat stress due to high temperatures can cause heat stroke, pyrexia, heat cramps, heart disease, and respiratory diseases, which seriously affect human health. Vitexin has been shown to alleviate heat stress; however, its mechanism of action remains unclear. Therefore, in this study, we used Caco-2 cells to establish a heat stress model and vitamin C as a positive control to investigate the regulatory effects of vitexin on heat-stress-induced apoptosis and the related mechanisms using Cell Counting Kit-8, flow cytometry, real-time quantitative polymerase chain reaction, and Western blot. The results showed that the mRNA expressions of Hsp27, Hsp70, and Hsp90 induced by heat stress could be effectively inhibited at vitexin concentrations as low as 30 μM. After heat stress prevention and heat stress amelioration in model cells based on this concentration, intracellular reactive oxygen species (ROS) levels and the mRNA level and the protein expression of heat shock proteins (Hsp70 and Hsp90) and apoptotic proteins were reduced. In addition, compared with the heat stress amelioration group, the expression of BCL2 mRNA and its protein (anti-apoptotic protein Bcl-2) increased in the heat stress prevention group, while the expression of BAX, CYCS, CASP3, and PARP1 mRNAs and their proteins (apoptotic proteins Bax, Cytochrome C, cle-Caspase-3, and cle-PARP1) were decreased. In summary, the heat-stress-preventive effect of vitexin was slightly better than its heat-stress-ameliorating effect, and its mechanism may be through the inhibition of intracellular ROS levels and thus the modulation of the expressions of Hsp70 and Hsp90, which in turn protects against heat-stress-induced apoptosis. This study provides a theoretical basis for the prevention and amelioration of heat stress using vitexin.

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“…Heat stress reduces broiler meat and table eggs, thereby causing great losses to poultry farms (Ebeid et al, 2012; Quinteiro‐Filho et al, 2010). Production is reduced because the stress response of chickens is elevated under heat stress; for example, heat stress causes a rapid increase in body temperature (Bahry et al, 2017; Han et al, 2017; Ito et al, 2015; Yang et al, 2016). Chickens have a limited capacity to dissipate body heat because they lack sweat glands and their bodies are covered by feathers (Ensminger et al, 1990; Marder & Arad, 1989).…”

Section: Introductionmentioning

confidence: 99%

Oral administration of L‐citrulline changes the concentrations of plasma hormones and biochemical profile in heat‐exposed broilers

Chowdhury

Ouchi

Han

et al. 2021

Animal Science Journal

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We examined the effects of oral administration of L-citrulline (L-Cit) on plasma metabolic hormones and biochemical profile in broilers. Food intake, water intake, and body temperature were also analyzed. After dual oral administration (20 mmol/ head/administration) of L-Cit, broilers were exposed to a high ambient temperature (HT; 30 AE 1 C) chamber for 120 min. Oral administration of L-Cit reduced (p < .001) rectal temperature in broilers. Food intake was increased (p < .05) by heat stress, but it was reduced (p < .05) by L-Cit. Plasma levels of 3,5,3 0 -triiodothyronine, which initially increased (p < .0001) due to heat stress, were reduced (p < .01) by oral administration of L-Cit. Plasma insulin levels were increased by heat exposure (p < .01) and oral L-Cit (p < .05). Heat stress caused a decline (p < .05) in plasma thyroxine. Plasma lactic acid (p < .05) and non-esterified fatty acids (p < .01) were increased in L-Cit-treated heat-exposed broilers. In conclusion, our results suggest that oral L-Cit can modulate plasma concentrations of major metabolic hormones and reduces food intake in broilers.

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Chronic oral administration of pine bark extract (flavangenol) attenuates brain and liver mRNA expressions of HSPs in heat-exposed chicks

Cited by 12 publications

References 46 publications

Dietary enzymatically treated Artemisia annua L. improves meat quality, antioxidant capacity and energy status of breast muscle in heat‐stressed broilers

Dietary enzymatically treated Artemisia annua L. improves meat quality, antioxidant capacity and energy status of breast muscle in heat‐stressed broilers

Vitexin Regulates Heat Shock Protein Expression by Modulating ROS Levels Thereby Protecting against Heat-Stress-Induced Apoptosis

Oral administration of L‐citrulline changes the concentrations of plasma hormones and biochemical profile in heat‐exposed broilers

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