Chronic pancreatitis

Abstract

Early diagnosis of pancreatitis may be improved by newer techniques associated with endoscopic ultrasonography imaging. Treatment of nutritional deficiencies and diabetes is an important aspect of treating chronic pancreatitis. Pain relief with adjunct means of pain modulation should be tried before starting narcotics for pain control. Endoscopic therapy is appropriate for treating chronic pancreatitis and its local complications and surgical intervention can be considered early in carefully selected individuals.

Chronic pancreatitis correlates with increased risk of herpes zoster in a population‐based retrospective cohort study

“…Nutritional insufficiency might cause protein–energy malnutrition, and decreased immune functions, particularly cell‐mediated immunity . The long‐time complications of chronic pancreatitis are recurrent abdominal pain, malabsorption (due to exocrine dysfunction), and inadequate intake of food (due to alcoholism and/or abdominal pain) . These complications lead to subsequent nutritional insufficiency , which lead to progressively declined immunity .…”

“…The long‐time complications of chronic pancreatitis are recurrent abdominal pain, malabsorption (due to exocrine dysfunction), and inadequate intake of food (due to alcoholism and/or abdominal pain) . These complications lead to subsequent nutritional insufficiency , which lead to progressively declined immunity . Thus, it further increases the likelihood of the reactivation of latent varicella‐zoster virus among patients with nutritional insufficiency, including those patients with chronic pancreatitis.…”

“…Chronic pancreatitis is a chronic inflammation of the pancreas that leads to progressive loss of the endocrine and exocrine functions due to the destruction of pancreatic parenchyma cells and replacement with fibrous tissue . In Western countries, the prevalence of chronic pancreatitis was about 30–49 cases per 100,000 persons .…”

“…Alcohol consumption accounts for at least 50% of causes of chronic pancreatitis . The most common complications of chronic pancreatitis are recurrent abdominal pain, diabetes mellitus (due to endocrine dysfunction), malabsorption (due to exocrine dysfunction), and inadequate intake of food (due to alcoholism and/or abdominal pain) and subsequent nutritional insufficiency . In addition, chronic pancreatitis is found to be associated with some comorbidities, including cerebrovascular disease, pyogenic liver abscess, inflammatory bowel disease, acute coronary syndrome, deep vein thrombosis, and pulmonary thromboembolism , but herpes zoster has not yet been studied.…”

Pancreatic cancer stromal biology and therapy

“…Chronic pancreatitis is a well-defined disease induced by repetitive acute injury or a self-perpetuating inflammatory process. 46 , 47 , 48 , 49 Constant tissue damage in cases of this disease leads to excessive stromal formation and, ultimately, exocrine insufficiency. 50 Chronic pancreatitis and pancreatic cancer have the similar property in that they bear large portions of the stroma.…”