Chronic periadolescent cannabinoid treatment enhances adult hippocampal PSA-NCAM expression in male Wistar rats but only has marginal effects on anxiety, learning and memory

Spontaneous object recognition and its relevance to schizophrenia: a review of findings from pharmacological, genetic, lesion and developmental rodent models

“…Exposure to cannabinoid agonists has been shown to impair SOR, although the severity of these impairments differs across studies. Subchronic adolescent exposure to THC or to a cannabinoid agonist impaired SOR in rats subsequently tested as adults with a delay of up to 1 h (1 h, Quinn et al 2008;30 min, Schneider and Koch 2003; but see Higuera-Matas et al 2009). Schneider and Koch (2003) observed no impairment with a 2-h delay.…”

Chronic Cannabinoid Administration to Periadolescent Rats Modulates the Metabolic Response to Acute Cocaine in the Adult Brain

“…Additionally, the sex-dependent nature of the effects reported here could be attributed to long-term changes in hormone levels, such as estradiol or corticosterone, both of which are affected by cannabinoids [21][22][23]. However, when we examined this possibility, we found no alterations in corticosterone or estradiol in animals exposed to CP [10].…”

“…Accordingly, four groups of animals were established: VH male (n 7), VH female (n 9), CP male (n 8) and CP female (n 9). The dose and duration of the CP treatment were chosen on the basis of previous studies on the long term effects of chronic periadoles cent CP treatment [4,9,10]. Animals were housed individually when they reached P75 in order to leave sufficient time between individual housing and the metabolic studies to avoid any non specific effects of isolation stress on the metabolic measurements.…”

The effects of adolescent cannabinoid exposure on seizure susceptibility and lethality in adult male rats

“…For instance, argue that the PFC and amygdala are affected by adolescent cannabinoid treatment to a greater degree in females than in males. Research on hippocampal vulnerability has been mixed, with some studies documenting stronger effects in males (Higuera-Matas et al, 2009;Rubino et al, 2009) and others indicating enhanced vulnerability in females (Higuera-Matas et al, 2012). It is possible that we would have seen more profound effects of cannabinoid treatment on seizure susceptibility in female rats.…”