Chronic Positive Mass Balance is the Actual Etiology of Obesity: Time for A Paradigm Shift?

Abstract

According to known laws of physics, chronic positive mass balance is the actual etiology of obesity, not positive energy balance. The relevant physical law in terms of body mass regulation is the Law of Conservation of Mass, not the Law of Conservation of Energy. A recently proposed mass balance model (MBM) describes the temporal evolution of body weight and body composition under a wide variety of feeding experiments, and it seems to provide a highly accurate description of the very best human experimental feeding data. By shifting to a mass balance paradigm of obesity, a deeper understanding of this disease may follow in the near future.

A reanalysis of the highly important metabolic ward feeding data of Hall and colleagues: a brief report

“…A growing body of evidence indicate that the widely accepted EBT ("Calories In, Calories Out) is a flawed paradigm. Instead, it is becoming increasingly clear that body mass is regulated according to the "Mass In, Mass Out" principle [2,3,4,5,6,9]. A very comprehensive and detailed review can be found in source [9], while a relatively easy-to-read and practical review can be found in [5].…”

“…Instead, it is becoming increasingly clear that body mass is regulated according to the "Mass In, Mass Out" principle [2,3,4,5,6,9]. A very comprehensive and detailed review can be found in source [9], while a relatively easy-to-read and practical review can be found in [5]. Indeed, the results of this well-controlled feeding experiment by Hall et A2.…”