Chronic Prostatitis Syndrome: A Common, but Poorly Understood Condition. Part II

Pavone‐Macaluso, M.

doi:10.1016/j.eeus.2006.10.001

Cited by 9 publications

(12 citation statements)

References 50 publications

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“…Prostate diseases include bacterial (CBP) and non-bacterial prostatitis (BPH) [1]. The therapeutic measures for CBP are mainly antibiotic prescription [6], whereas BPH is treated with αadrenergic blocking agents and 5-α-reductase inhibitors [2], or often by phytotherapy using phytochemicals such as a polyphenolic flavonoid [4].…”

Section: Figurementioning

confidence: 99%

“…Prostatitis and prostate hyperplasia are diseases that commonly occur during men's lifespan all over the world, and 35-50% of men have prostatitis at some time in their lives [1,2]. Prostate diseases include chronic bacterial prostatitis (CBP), benign prostatic hyperplasia (BPH), and prostate cancer [2][3][4][5].…”

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confidence: 99%

“…Prostate diseases include chronic bacterial prostatitis (CBP), benign prostatic hyperplasia (BPH), and prostate cancer [2][3][4][5]. Prostatitis is frequently present in aging men, and many patients are suffering from chronic prostatitis syndrome [1,5,6]. Chronic prostatitis of bacterial and nonbacterial origin is a very common disease in men; nevertheless, there are no established management strategies in everyday life.…”

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confidence: 99%

“…[10]. If the symptoms persist, chronic prostatitis can progress to bacterial cystitis, pelvic pain, and acute pyelonephritis [1,4]. BPH commonly occurs in aged men, accordingly general preventive and therapeutic measures have to be planned for a long time [5].…”

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confidence: 99%

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Preventive Effects of Resveratrol-enriched Extract of Peanut Sprout on Bacteria- and Estradiol-induced Prostatitis in Mice

Pyo

Lee

et al. 2017

Natural Product Communications

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The present study investigated the effect of peanut sprout extract (PSE) as a natural resveratrol supplement on chronic bacterial prostatitis (CBP) and estradiolinduced benign prostatic hyperplasia (BPH). PSE contained a high level of resveratrol (148.51 ± 3.05 µg/g), and was tested on the mouse models of CBP (induced by Escherichia coli 292 infection) and BPH (induced by treatment with β-estradiol and dihydrotestosterone). PSE toxicity was assessed on the basis of changes in body weight, alanine aminotransferase activity (an indicator of hepatotoxicity), and expression of the kidney injury marker KIM-1. The effects of PSE on the histopathology of prostate tissue, the proportion of neutrophils, and immune cell profiles in the blood and spleen were examined. PSE administration did not result in any toxicity but reduced the bacterial burden and histopathological changes in the prostate. In addition, lymphocytes (CD4 + , CD8 + , and CD19 +) in the spleen were significantly increased after PSE administration in CBP mice, suggesting immune enhancement. PSE treatment of bone marrow-derived macrophages increased the expression of CD40, which is related to the pro-inflammatory function and host defense against pathogens. It is concluded that PSE would be a good supplement for the mitigation of prostate hyperplasia and prostatitis.

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Section: Figurementioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Preventive Effects of Resveratrol-enriched Extract of Peanut Sprout on Bacteria- and Estradiol-induced Prostatitis in Mice

Pyo

Lee

et al. 2017

Natural Product Communications

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“…Chronic prostatitis (CP) is functional, somatoform disorder with a high worldwide prevalence estimated in systematic reviews or population studies at 10-32% [1][2][3][4][5]. However, CP is a more common condition, with 35-50% of men reported to be affected by symptoms suggesting prostatitis during their lifetime [6,7].…”

Section: Introductionmentioning

confidence: 99%

Br, Fe, Rb, Sr, and Zn Levels in the Prostatic Secretion of Patients with Chronic Prostatitis

Vladimir¹,

Sofia²

2018

Int Arch Urol Complic

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Objective: Chronic prostatitis (CP) is an internationally important health problem of the man, particularly in developed countries. The aim of this exploratory study was to evaluate whether significant changes in the levels of Zn and some other trace elements of prostatic fluid exist in the inflamed prostate. Methods: Prostatic fluid levels of Br, Fe, Rb, Sr, and Zn were prospectively evaluated in 33 patients with CP and 42 healthy male inhabitants. Measurements were performed using 109 Cd radionuclide-induced energy dispersive X-ray fluorescent microanalysis. Prostatic fluid samples were divided into two portions. One was used for cytological and bacteriological investigations while the other was intended for trace element analysis. Results: Mean values ± standard error of means (M ± SΕΜ) for concentration (mg/L) of trace element in the expressed prostatic fluid (EPF) of normal prostate were: Br 2.86 ± 0.59, Fe 8.30 ± 1.42, Rb 1.16 ± 0.10, Sr 1.27 ± 0.17, and Zn 598 ± 34. It was observed that in the EPF of inflamed prostate content of Rb significantly increased whereas content of Zn decreased in a comparison with those in the EPF of normal prostate. Conclusions: There are significant changes in trace element contents and their relationships in the fluid of CP prostate. The alterations in levels of Zn and Rb in the EPF of inflamed prostate might demonstrate an involvement of these trace elements in etiology and pathogenesis of CP. It was supposed that the changes of Zn and Rb levels in the EPF samples can be used as CP markers.

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Herbal formula (Danggui Beimu Kushen Wan) for prostate disorders: a systematic review of classical literature

Hung

Yang

2019

Integrative Medicine Research

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BackgroundDanggui Beimu Kushen Wan (DBKW) was initially known for difficult urination in pregnancy and has been widely used for prostate disorders in modern days. This study aimed to comprehensively investigate the implications of DBKW in traditional evidence.MethodsThe Encyclopedia of Traditional Chinese Medicine was searched to identify the ingredients, dosage, etiologies, pathogeneses, actions and indications related to DBKW documented in ancient books. Descriptive summary was provided to their characteristics.ResultsA total of 41 texts in 36 classic books were included. Two etiologies and 10 pathogeneses were investigated. All the identified formulas contain Angelicae Sinensis Radix, Fritillariae Thunbergii Bulbus and Sophorae Flavescentis Radix with the ratio of 1:1:1. The treatment dosage is three to 10 pills each time. The primary indication of DBKW is difficult urination with heat stagnation. Nine included texts specified that this formula could also be used for male.ConclusionIncluded classic literature has provided fundamental evidence for the management of difficult urination in female and male. Further studies should investigate its mechanisms of actions for difficult urination related conditions, such as prostate disorders.

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Chronic Prostatitis Syndrome: A Common, but Poorly Understood Condition. Part II

Cited by 9 publications

References 50 publications

Preventive Effects of Resveratrol-enriched Extract of Peanut Sprout on Bacteria- and Estradiol-induced Prostatitis in Mice

Preventive Effects of Resveratrol-enriched Extract of Peanut Sprout on Bacteria- and Estradiol-induced Prostatitis in Mice

Br, Fe, Rb, Sr, and Zn Levels in the Prostatic Secretion of Patients with Chronic Prostatitis

Herbal formula (Danggui Beimu Kushen Wan) for prostate disorders: a systematic review of classical literature

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