Chronic Pulmonary Histoplasmosis and its Clinical Significance: an Under-reported Systemic Fungal Disease

Kandi, Venkataramana; Vaish, Ritu; Palange, Padmavali; Bhoomagiri, Mohan Rao

doi:10.7759/cureus.c6

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Human infections caused by Histoplasma capsulatum may present as acute pulmonary histoplasmosis, chronic pulmonary histoplasmosis, and progressive disseminated histoplasmosis. Patients with underlying lung disease are specifically at risk for developing chronic pulmonary histoplasmosis, which may resemble reactivation of tuberculosis in its clinical presentation and radiological appearance [ 4 ]. Our case involved a young patient with chronic pulmonary histoplasmosis and selective IgM deficiency but without underlying lung disease.…”

Section: Discussionmentioning

confidence: 99%

Chronic Pulmonary Histoplasmosis Identified in a Young Patient with Selective Immunoglobulin M Deficiency

Preneta

Nada

Raja

et al. 2018

Case Reports in Infectious Diseases

View full text Add to dashboard Cite

Chronic histoplasmosis is typically diagnosed in patients who are immunocompromised or severely debilitated and who either live in or who have travelled to endemic areas. We report the case of a young, otherwise immunocompetent male patient who presented to a New York hospital with lobar consolidation and was found to have chronic pulmonary histoplasmosis. He described no history of travel to an endemic area. Immunological workup later revealed selective immunoglobulin M (IgM) deficiency. The literature has suggested a link between IgM deficiency and fungal infections. Recent research has also proposed a link between autoimmunity and IgM deficiency. Our clinical vignette describes the case of a patient with selective IgM deficiency who was diagnosed with pulmonary histoplasmosis without any clinical evidence of autoimmune disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Chronic Pulmonary Histoplasmosis Identified in a Young Patient with Selective Immunoglobulin M Deficiency

Preneta

Nada

Raja

et al. 2018

Case Reports in Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…Os padrões moleculares associados aos patógenos (PAMPs) presentes na parede celular do fungo, são reconhecidos pelos receptores padrões das células de defesa sendo fagocitados, e, por consequência, da temperatura corporal (37°C), sofrem a conversão para a fase leveduriforme, acompanhada de mudanças genéticas, bioquímicas, e físicas do fungo, induzindo uma reação inflamatória no hospedeiro, e instalação da infecção pulmonar (Lima, 2013;Kandi et al, 2016).…”

Section: Aspectos Clínicos Da Histoplasmoseunclassified

“…A análise da cultura é feita por meio de duas etapas: primeiramente ocorre a identificação da fase filamentosa do fungo, no meio de cultura sob temperatura de 25º a 27ºC, possuindo crescimento entre 15 a 30 dias, onde através da macromorfologia a colônia apresenta-se com coloração branca, que ao passar dos dias pode assumir a cor acastanhada, aspecto algodonoso, superfície lisa, que pode transformar-se em filamentos (Figura 4A) (Kandi et al, 2016). Após isto, ocorre a confirmação do dimorfismo, no meio BHI ou ágar Research, Society and Development, v. 9, n. 7, e476974353, 2020 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v9i7.4353 sangue sob 37ºC, e é possível observar colônias com coloração branca a marrom, superfície lisa ou rugosa, brilhante e textura cremosa e úmida (Figura 4B) (Silva, 2013).…”

Section: Diagnóstico Micológicounclassified

Aspectos clínicos e laboratoriais da histoplasmose: uma revisão bibliográfica

Oliveira

Felix²,

Farias

et al. 2020

RSD

View full text Add to dashboard Cite

Histoplasmosis is a systemic mycosis, endemic, of worldwide distribution, which is caused by inhaling the propagules of Histoplasma capsulatum, in which they lodge in the lungs and subsequently trigger the human infection that can spread through the body. The forms of clinical manifestations vary according to the degree of impairment of the immune system of the individual. Therefore, the present study aims to describe the clinical and laboratory aspects of Histoplasmosis, by understanding that, today, errors still occur when identifying this mycosis, which leads to the increase of mortality, so early diagnosis is essential for the quality of life of the individuals. The study was based on a bibliographic review, with a qualitative approach, of an exploratory type. Because Histoplasmosis is an opportunistic mycosis, capable of affecting different organs and tissues, better training of professionals is necessary, associated with the application of the correct diagnostic techniques. Thus, it is concluded that the diagnosis made through laboratory techniques, such as the mycological, serological, histopathological, molecular examination, are fundamental for the early and correct diagnosis of the individual, which will contribute to improve therapeutic action.

show abstract

Microbes, Clinical trials, Drug Discovery, and Vaccine Development: The Current Perspectives

et al. 2021

Self Cite

View full text Add to dashboard Cite

Because of the frequent emergence of novel microbial species and the re-emergence of genetic variants of hitherto known microbes, the global healthcare system, and human health has been thrown into jeopardy. Also, certain microbes that possess the ability to develop multi-drug resistance (MDR) have limited the treatment options in cases of serious infections, and increased hospital and treatment costs, and associated morbidity and mortality. The recent discovery of the novel Coronavirus (n-CoV), the Severe Acute Respiratory Syndrome CoV-2 (SARS-CoV-2) that is causing the CoV Disease-19 (COVID-19) has resulted in severe morbidity and mortality throughout the world affecting normal human lives. The major concern with the current pandemic is the non-availability of specific drugs and an incomplete understanding of the pathobiology of the virus. It is therefore important for pharmaceutical establishments to envisage the discovery of therapeutic interventions and potential vaccines against the novel and MDR microbes. Therefore, this review is attempted to update and explore the current perspectives in microbes, clinical research, drug discovery, and vaccine development to effectively combat the emerging novel and re-emerging genetic variants of microbes.

show abstract

Chronic Pulmonary Histoplasmosis and its Clinical Significance: an Under-reported Systemic Fungal Disease

Cited by 3 publications

References 0 publications

Chronic Pulmonary Histoplasmosis Identified in a Young Patient with Selective Immunoglobulin M Deficiency

Chronic Pulmonary Histoplasmosis Identified in a Young Patient with Selective Immunoglobulin M Deficiency

Aspectos clínicos e laboratoriais da histoplasmose: uma revisão bibliográfica

Microbes, Clinical trials, Drug Discovery, and Vaccine Development: The Current Perspectives

Contact Info

Product

Resources

About