1991
DOI: 10.1055/s-2008-1042505
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Chronic Recurrent Appendicitis. A Clinicopathologic Study of 47 Cases*

Abstract: As part of a retrospective study 47 appendices from patients with a clinical and morphologic diagnosis of chronic recurrent appendicitis were studied by morphologic and immunohistochemical methods. Appendices with chronic recurrent appendicitis histologically show chronic active inflammation with increased numbers of immunocompetent cells, mostly T lymphocytes and subsequent scarring. In addition, there is an increase in the number of neural cells. Apparently the secretion of neurotropic inflammatory mediators… Show more

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Cited by 24 publications
(16 citation statements)
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“…It has also been suggested that appendices harbour chronic inflammatory reaction of unknown etiology mediated largely by T lymphocytes. 4 Clearly, where histology of the appendix reveals intrinsic pathology, appendicectomy would be generally curative. [11][12][13] With 9 of 11 patients in the current series showing a distinctive pathologic profile, this lends further support to removal of the appendix.…”
Section: Discussionmentioning
confidence: 99%
“…It has also been suggested that appendices harbour chronic inflammatory reaction of unknown etiology mediated largely by T lymphocytes. 4 Clearly, where histology of the appendix reveals intrinsic pathology, appendicectomy would be generally curative. [11][12][13] With 9 of 11 patients in the current series showing a distinctive pathologic profile, this lends further support to removal of the appendix.…”
Section: Discussionmentioning
confidence: 99%
“…Acute and chronic inflammations of the appendix were reviewed and chronic inflammation was diagnosed when lymphocytes and eosinophils were present within the appendiceal wall and fibrosis was associated with the presence hematoxylin and eosin during histopathological examination [12][13][14].…”
Section: Evaluation Criteriamentioning
confidence: 99%
“…27 Unfortunately there is no laboratory or radiological finding at times suggestive of chronic appendicitis, they all remain within normal limits. 28 Presence of adhesions and fibrosis in and around appendix observed by surgeon at laprotomy is sufficient for the diagnosis of chronic appendicitis as it has 93.5% specificity and 77.8% sensitivity, Mussack T, et al 29 Sometime even these features are not so prominent to explain pain however gross observation cannot replace pathological confirmation. 30,31 Histopathology of specimen showed features of chronic inflammation namely fibrotic changes lymphocytic infiltration and luminal obstruction justifies the decision taken.…”
Section: Discussionmentioning
confidence: 99%