Chronic Renal Disease and Heavy use of Analgesics

Reynolds, Telfer B.

doi:10.1001/jama.1963.03700190053006

Cited by 35 publications

(3 citation statements)

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“…In some patients who discontinued analgesics, follow-up studies for at least 1 year have not shown improvement in renal function (Reynolds & Edmondson, 1963).…”

Section: Discussionmentioning

confidence: 99%

Analgesic nephropathy

Hulme

Jones

1967

Postgraduate Medical Journal

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“…In some patients who discontinued analgesics, follow-up studies for at least 1 year have not shown improvement in renal function (Reynolds & Edmondson, 1963).…”

Section: Discussionmentioning

confidence: 99%

Analgesic nephropathy

Hulme

Jones

1967

Postgraduate Medical Journal

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Acute Renal Failure Following Analgesic Overdose in G6pd Deficiency

Brown

McMillan

Bateman

et al. 1972

British Journal of Urology

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THE association between the abuse of analgesics containing phenacetin and chronic interstitial nephritis with renal papillary necrosis is now well established (Spuhler and Zollinger, 1953;Larsen and Moller, 1959;Nordenfelt and Ringertz, 1961 ;Reynolds and Edmondson, 1963;Dawborn et al., 1966; Prescott, 1966). Less well known is the oxidant effect of phenacetin causing acute hzemolysis in susceptible persons, notably those with red cell glucose-6-phosphate dehydrogenase (G6PD) deficiency (Houston and Barlow, 1959;Gilles and Ikeme, 1960;Harley, 1961 ;Harley and Robin, 1962; Dodion-Fransen, 1963). The combination of phenacetin intoxication and acute hzmolytic renal failure with subsequent papillary necrosis has not been reported. Finally, chronic ingestion of phenacetin has been shown to cause sideroblastic anzmia in a few patients (Dacie and Mollin, 1966), but this has not been described as a complication of acute analgesic overdosage.Case Report.-A 33-year-old West-Indian Negro male was admitted to another hospital in June 1969, 3 hours after taking 100 Codeine Compound tablets. As each tablet of Codeine Compound contains 250 mg. of Phenacetin, 250 mg. of Aspirin and 8 mg. of Codeine, a total of 25 g. of Phenacetin, 25 g. of Aspirin and 800 mg. of Codeine was ingested. Five months previously he had taken a small amount of the same type of tablet without any ill effects. He was not admitted to hospital on that occasion. In the past he had had occasional episodes of epigastric pain relieved by antacids,and headaches for which he took various analgesics, reputedly in small quantities. He had had no previous symptoms of loin pain, renal or ureteric colic or hsmaturia. There was no past history of any untoward reactions following drug ingestion by the patient or his family.On admission he was fully conscious, but depressed. He was neither anamic (Hb. 90 per cent, 13.3 g. per cent), nor icteric, and there were no abnormal physical findings. His urine was recorded as being " reddish " in colour. The blood urea and serum salicylate levels were not measured at this time. A stomach washout was performed on admission. This was followed by the intravenous infusion of 2 : litres of dextrose-saline over 24 hours combined with a single initial dose of 60 mg. of frusemide, which produced a good diuresis (Fig. 1). He remained well, normotensive and maintained a satisfactory urine output while receiving 3 litres of oral fluids daily. On the 3rd day he started vomiting and became oliguric. There was no response to an infusion of 500 ml. of 10 per ceid mannitol. At this time his blood urea was 109 mg./100 ml., his serum was stained deep brownish-red by methsnrdbumin and oxyhsmoglobin, and the serum salicylate concentration was 21 mg./100 ml. By the 4th day he was icteric and anuric, the hzmoglobin had fallen to 60 per cent (8.9 g. per cent) and the blood urea had risen to 174 mg./ 100 mi. Oliguric renal failure due to acute intravascular haemolysis was diagnosed and he was transferred to the

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“…folgten später Berichte aus Skandinavien (6, 10,11,22,29,42,45,47,57), aus der Bundes-republik Deutschland (36, 52, 72-74, 82, 89-91), aus England (1,5,23,28,49,71,85), den USA (7,20,21,33,34,58,62,67,[77][78][79]94), Kanada (65), Australien (44,60) und Südafrika (69). * Professor Dr. O. H. Arnold zum 60. Geburtstag.…”

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