Chronic rhinosinusitis in Europe - an underestimated disease. A GA2LEN study

Hastan, Deniz; Fokkens, W. J.; Bachert, Claus; Newson, R B; Bislimovska, Jovanka Karadzinska; Bockelbrink, Angelina; Bousquet, P.; Brożek, Grzegorz; Bruno, Andreina; Dahlén, SE; Forsberg, Bertil; Gunnbjörnsdóttir, Mari­a; Kasper, Łukasz; Krämer, Ursula; Kowalski, Marcin; Lange, Bibi; Lundbäck, Bo; Salagean, E; Todo-Bom, Ana; Tomassen, Peter; Toskala, Elina; Drunen, Cornelis M. van; Bousquet, Jean; Zuberbier, Torsten; Jarvis, Déborah; Burney, Peter

doi:10.1111/j.1398-9995.2011.02646.x

Cited by 939 publications

(887 citation statements)

References 21 publications

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“…CRS is an underestimated common condition, affecting 11% of the total European population 1, 10. Although state‐of‐the‐art guidelines provide evidence‐based treatment algorithms, a significant portion of patients remain uncontrolled, despite prolonged medical treatment and one or more surgical interventions.…”

Section: Discussionmentioning

confidence: 99%

Real-life study showing uncontrolled rhinosinusitis after sinus surgery in a tertiary referral centre

Veen

Seys

Timmermans

et al. 2016

Allergy

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128

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RationaleThe European Position Paper on Sinusitis (EPOS) guidelines provide composite criteria to evaluate chronic rhinosinusitis (CRS) control, taking into consideration the severity of patients’ symptoms, aspect of nasal mucosa and medical intake as parameters of CRS control.ObjectivesTo study the degree of CRS control using novel EPOS control criteria at 3–5 years after a functional endoscopic sinus surgery (FESS) and correlate these data to symptoms scores.MethodsAdult CRS patients (n = 560) who had undergone bilateral FESS for chronic inflammatory sinonasal disease 3–5 years prior to the study were included. Patients received a postal questionnaire asking for control items according to EPOS control criteria, visual analogue scale (VAS) scores for total and individual sinonasal symptoms, sinonasal outcome test (SNOT)‐22 and Short Form (SF)‐36 questionnaires.Measurements and main resultsAbout 19.5% of CRS patients were well controlled, with 36.8% of patients being partly controlled and 43.7% uncontrolled. The levels of control corresponded to mean total VAS, SNOT‐22 and SF‐36 scores. Subgroup analysis revealed that female gender, aspirin intolerance and revision FESS were associated with higher prevalence of uncontrolled CRS, whereas allergy, asthma and smoking status did not alter the percentage of patients in each category of control. In 81 patients attending the outpatient clinic, nasal endoscopy changed classification in only four patients (4.9%).ConclusionsBased on the novel EPOS control criteria, at least 40% of CRS patients are uncontrolled at 3–5 years after FESS. Therefore, better treatment strategies leading to higher disease control are warranted in CRS care.

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Section: Discussionmentioning

confidence: 99%

Real-life study showing uncontrolled rhinosinusitis after sinus surgery in a tertiary referral centre

Veen

Seys

Timmermans

et al. 2016

Allergy

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128

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“…Chronic rhinosinusitis (CRS) is a common upper airway infectious condition affecting up to 11% of the European population [10] and is a prominent risk factor for asthma.…”

Section: Reactive Oxygen Species As a Novel Adjunctive Biofilm-targetmentioning

confidence: 99%

Reactive oxygen: A novel antimicrobial mechanism for targeting biofilm-associated infection

Dryden

Cooke

Salib

et al. 2017

Journal of Global Antimicrobial Resistance

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Reactive oxygen: a novel antimicrobial mechanism for targeting biofilm-associated infection, http://dx.doi.org/10. 1016/j.jgar.2016.12.006 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…В исследование вошли 57 128 респон-дентов из 12 стран. Примечательно, что лишь у 5,0% из них был уже установленный диагноз «хронический рино-синусит», однако по результатам тестирования, в соответ-ствии с критериями EP 3 OS [7], оказалось, что хрониче-ским риносинуситом в действительности страдают 10,9% респондентов [13].…”

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“…В 2013 г. заболеваемость острым риносинуситом в Канаде соста-вила около 5 000 на 100 000 населения [19]. В Европе распространенность по разным странам оценивается в более широких пределах -от 6,9 до 27,1% [13]. По оцен-ке A.M. Halawi et al (2015) [20], распространенность хро-нического риносинусита в США составляет от 2 до 16%.…”

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Rhinosinusitis: classification, epidemiology, etiology and treatment

Krivopalov¹

2016

Med. sov.

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Chronic rhinosinusitis in Europe - an underestimated disease. A GA2LEN study

Abstract: This is the first European international multicentre prevalence study of CRS. In this multicentre survey of adults in Europe, about one in ten participants had CRS with marked geographical variation. Smoking was associated with having CRS in all parts of Europe.

Cited by 939 publications

References 21 publications

Real-life study showing uncontrolled rhinosinusitis after sinus surgery in a tertiary referral centre

Real-life study showing uncontrolled rhinosinusitis after sinus surgery in a tertiary referral centre

Reactive oxygen: A novel antimicrobial mechanism for targeting biofilm-associated infection

Rhinosinusitis: classification, epidemiology, etiology and treatment

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