Chronic sleep disorder induced by psychophysiological stress induces glucose intolerance without adipose inflammation in mice

Dietary Heat-Killed <i>Lactobacillus brevis</i> SBC8803 Attenuates Chronic Sleep Disorders Induced by Psychophysiological Stress in Mice

“…Plasma levels of catecholamines such as adrenaline and noradrenaline were significantly elevated, whereas corticosterone levels were slightly affected in mice with CSD, suggesting that the stress applied herein activated the sympathetic-adrenal medullary axis (13). The mice with CSD notably had hyperphasia accompanied by hypoleptinemia and impaired glucose tolerance (14,15), which resembles the situation found in insomniac humans. These model mice would be useful for evaluating the effects of probiotics on stress-induced circadian sleep disorders.…”

“…The mice were then fed with purified AIN-93M rodent diet (Charles-River Co. Ltd., Wilmington, MA, USA) with or without (control) 0.5% heat-killed SBC8803 (6, 16) for 6 wk. They were then exposed to 2 wk of psychophysiological stress for CSD induction as described (13)(14)(15). Briefly, paper-chip bedding was replaced with water to a depth of 1.5 cm depth which caused the mice to stay on a wheel for 24 h every day.…”

“…Classical mouse models of CSD such as disk-overwater, gentle handling, platform (also called flower-pot), and slowly rotating wheels artificially affect circadian behavioral rhythms by providing circadian time cues, because they are based on daily forced physical sleep deprivation (12). We developed a model of CSD induced by psychophysiological stress characterized by a reduced amplitude of circadian rhythms such as wheel-running, sleep-wake cycles, sleep fragmentation and hyperphagia for several weeks without adaptation (13)(14)(15). Plasma levels of catecholamines such as adrenaline and noradrenaline were significantly elevated, whereas corticosterone levels were slightly affected in mice with CSD, suggesting that the stress applied herein activated the sympathetic-adrenal medullary axis (13).…”

Ações Neuro-Hormonais E Comportamentais Dos Aditivos Alimentares

“…Os efeitos da tartrazina no comportamento de crianças têm sido reportados, principalmente seus efeitos na hiperatividade (FEINGOLD, 1979 (FEINGOLD, 1979). (OISHI et al, 2016(OISHI et al, , 2018. Todavia, ainda não há estudos em humanos que mostrem efeitos da sacarina no sono.…”

Ações Toxicológicas Dos Aditivos Alimentares No Sistema Cardiovascular

“…Como foi mencionado, o ciclo circadiano é responsável e essencial para uma boa manutenção do sono, e os distúrbios em seus mecanismos, podem provocar distúrbios do sono e perda da qualidade do sono. Nesse ponto, em estudos em ratos que foram submetidos a beber água com adição de sacarina à vontade, mostraram que eles apresentaram modificações do ciclo circadiano sono-vigília no que tange aumento da vigília e do sono não REM durante a fase de ativação (OISHI et al, 2016(OISHI et al, , 2018. Todavia, ainda não há estudos em humanos que mostrem efeitos da sacarina no sono.…”