Chronic stress causes neuroendocrine-immune disturbances without affecting renal vitamin D metabolism in rats

Jiang, Pei; Zhang, L.; Zhu, Wenye; Li, H.; Dang, Ruili; Tang, Mimi

doi:10.1007/s40618-014-0191-5

Cited by 10 publications

(11 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The observed noncorresponding changes in the activity, protein, and mRNA levels of the investigated CYP isoforms suggest some posttranscriptional or posttranslational modifications in CYP expression produced by CMS in the liver. The observed changes in CYP expression and activity may be caused by the ability of CMS to produce alterations in the function of the brain nervous system (Willner, 2016), which leads to the release of glucocorticoids and catecholamines, and modifications in the immune system (Kvetnansky et al, 2009;Jiang et al, 2014;Konstandi et al, Fig. 4.…”

Section: Downloaded Frommentioning

confidence: 99%

“…However, these effects may be modified by catecholamines (adrenaline, noradrenaline) acting positively via hepatocyte a 1 and b 1/2 adrenergic receptor through the cAMP response element-binding protein pathway, but negatively via pancreatic b 2 receptor through the insulin pathway (Konstandi, 2013) on CYP expression (Konstandi, 2013). Moreover, CMS-induced immune disturbances that lead to elevation of plasma proinflammatory cytokines (interleukin-6, tumor necrosis factor-a, and tumor necrosis factor-g) may additionally diminish enzyme expression (Zidek et al, 2009;Jiang et al, 2014).…”

Section: Downloaded Frommentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Chronic Treatment with Lurasidone on Rat Liver Cytochrome P450 Expression and Activity in the Chronic Mild Stress Model of Depression

et al. 2017

View full text Add to dashboard Cite

Recent studies indicated an important role of the monoaminergic nervous systems (dopaminergic, noradrenergic, and serotonergic systems) and stress in the regulation of cytochrome P450 (CYP) expression and activity in the liver. The aim of our present research was to determine the effect of the novel atypical neuroleptic drug with antidepressant properties lurasidone, on the expression (mRNA and protein level) and activity of liver CYP isoforms involved in the metabolism of drugs and endogenous steroids, in the chronic mild stress (CMS) model of depression. Male Wistar rats were subjected to CMS for 7 weeks. Lurasidone (3 mg/kg per os per day) was administered to nonstressed or stressed animals for 5 weeks (weeks 3-7 of CMS). It has been found that 1) CMS moderately affects CYP (CYP2B, CYP2C11, and CYP3A), and its effects are different from those observed after other kinds of psychologic stress, such as repeated restraint stress or early-life maternal deprivation; 2) chronic lurasidone influences the expression and/or activity of CYP2B, CYP2C11, and CYP3A isoforms; and 3) CMS modifies the action of lurasidone on CYP expression and function, leading to different effects of the neuroleptic in nonstressed and stressed rats. Based on the obtained results, it can be suggested that the metabolism of endogenous substrates (e.g., steroids) and drugs, catalyzed by the isoforms CYP2B, CYP2C11, or CYP3A, may proceed at a different rate in the two groups of animals (nonstressed and stressed) in the rat CMS model.

show abstract

Section: Downloaded Frommentioning

confidence: 99%

Section: Downloaded Frommentioning

confidence: 99%

The Effect of Chronic Treatment with Lurasidone on Rat Liver Cytochrome P450 Expression and Activity in the Chronic Mild Stress Model of Depression

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Hippocampal neurons in individuals with 22q11.2 deletion may already be vulnerable before chronic stress due to several factors including vitamin D insufficiency. Vitamin D insufficiency combined with exposure to chronic stress may be sufficient to further reduce expression of VDR and CYP27B1/CYP27A1 in the hippocampus, leading to a decrease in local production of vitamin D. As suggested by Jiang et al, 78 over time reduced expression of VDR/CYP27B1/ CYP27A1 may leave hippocampal neurons vulnerable to GC-induced cell death and further increase the risk for pathologies such as anxiety, depression and the development of schizophrenia.…”

Section: Discussionmentioning

confidence: 95%

“…4 A recent series of experiments examining GC exposure in an animal model of depression lends support to this hypothesis, and suggests that hippocampal vitamin D signaling may be involved in a compensatory adaptive response to allostatic load induced by chronic stress. 32,77,78 Lower vitamin D levels associated with impaired cognitive function has been reported in a number of studies. 79,80,81 Similarly, for children in the current study, lower full-scale IQ and poorer perceptual reasoning was associated with lower vitamin D blood concentrations.…”

Section: Discussionmentioning

confidence: 96%

Vitamin D deficiency, behavioral atypicality, anxiety and depression in children with chromosome 22q11.2 deletion syndrome

Kelley

Sanders

Beaton

2016

J Dev Orig Health Dis

View full text Add to dashboard Cite

Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a complex developmental disorder with serious medical, cognitive and emotional symptoms across the lifespan. This genetic deletion also imparts a lifetime risk for developing schizophrenia that is 25–30 times that of the general population. The origin of this risk is multifactorial and may include dysregulation of the stress response and immunological systems in relation to brain development. Vitamin D is involved in brain development and neuroprotection, gene transcription, immunological regulation and influences neuronal signal transduction. Low levels of vitamin D are associated with schizophrenia, depression and anxiety in the general population. Yet, little is known about how vitamin D levels in children with 22q11.2DS could mediate risk of psychosis in adulthood. Blood plasma levels of vitamin D were measured in children aged 7–16 years with (n = 11) and without (n = 16) 22q11.2DS in relation to parent reports of children’s anxiety and atypicality. Anxiety and atypicality in childhood are risk indicators for the development of schizophrenia in those with 22q11.2DS and the general population. Children with 22q11.2DS had lower vitamin D levels, as well as elevated anxiety and atypicality compared with typical peers. Higher levels of anxiety, depression and internalizing problems but not atypicality were associated with lower levels of vitamin D. Vitamin D insufficiency may relate to higher levels of anxiety and depression, in turn contributing to the elevated risk of psychosis in this population. Further study is required to determine casual linkages between anxiety, stress, mood and vitamin D in children with 22q11.2DS.

show abstract

“…INE system is stereonetwork regulation system with high precision and high complexity through cytokine, hormone, and other chemistry substances [28,29]. Physical and chemical biological characteristic of medium and hormone secreted by neuroendocrine system and lymph gene, monocyte secreted by immune system, and existing receptor in INE system cell surface are gradually discovered with the molecule-biology development.…”

Section: Neuroendocrine System Regulating Immune System Mechanismmentioning

confidence: 99%

Optimization on Black Box Function Optimization Problem

Xiao

Liu

et al. 2015

Mathematical Problems in Engineering

View full text Add to dashboard Cite

There are a large number of engineering optimization problems in real world, whose input-output relationships are vague and indistinct. Here, they are called black box function optimization problem (BBFOP). Then, inspired by the mechanism of neuroendocrine system regulating immune system, BP neural network modified immune optimization algorithm (NN-MIA) is proposed. NN-MIA consists of two phases: the first phase is training BP neural network with expected precision to confirm input-output relationship and the other phase is immune optimization phase, whose aim is to search global optima. BP neural network fitting without expected fitting precision could be replaced with polynomial fitting or other fitting methods within expected fitting precision. Experimental simulation confirms global optimization capability of MIA and the practical application of BBFOP optimization method.

show abstract

Chronic stress causes neuroendocrine-immune disturbances without affecting renal vitamin D metabolism in rats

Abstract: Our data suggest that the stress-induced neuroendocrine-immune disturbances may account for the development of depression, but are not responsible for the insufficient VD status that frequently observed in depressed patients.

Cited by 10 publications

References 37 publications

The Effect of Chronic Treatment with Lurasidone on Rat Liver Cytochrome P450 Expression and Activity in the Chronic Mild Stress Model of Depression

The Effect of Chronic Treatment with Lurasidone on Rat Liver Cytochrome P450 Expression and Activity in the Chronic Mild Stress Model of Depression

Vitamin D deficiency, behavioral atypicality, anxiety and depression in children with chromosome 22q11.2 deletion syndrome

Optimization on Black Box Function Optimization Problem

Contact Info

Product

Resources

About