Chronic stress modulates the use of spatial and stimulus-response learning strategies in mice and man

Schwabe, Lars; Dalm, Sergiu; Schächinger, Hartmut; Oitzl, Melly S.

doi:10.1016/j.nlm.2008.07.015

Cited by 201 publications

(146 citation statements)

References 44 publications

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“…This clear-cut sex difference was further extended to learning strategies under acute stress. Stressed females increasingly used a spatial strategy on the CHB task, whereas stressed male mice switched towards a S-R strategy [4,5,16]. Our results are supported by previous findings that naive females have no preference for either of the two strategies.…”

Section: Discussionsupporting

confidence: 90%

“…Male mice and rats seem to prefer the use of a spatial strategy [4][5][6][7], while females apply both strategies [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…In response to stress, strategy preference of male mice and rats switches from spatial towards more S-R learning [Schwabe et al, 2010a;Schwabe et al, 2008;Kim & Baxter, 2001), thereby rescuing their performance [Schwabe et al, 2010a;Schwabe et al, 2008). The effect of stress on strategy use of female mice has not been investigated so far.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Stress and estrous cycle affect strategy but not performance of female C57BL/6J mice

Horst

Kentrop

Kloet

et al. 2013

Behavioural Brain Research

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Section: Discussionsupporting

confidence: 90%

“…Male mice and rats seem to prefer the use of a spatial strategy [4][5][6][7], while females apply both strategies [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Stress and estrous cycle affect strategy but not performance of female C57BL/6J mice

Horst

Kentrop

Kloet

et al. 2013

Behavioural Brain Research

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“…A trial of special interest is the first trial after the first environmental change, as it gives an indication of the initial preference for either memory system when participants do not know yet if objects are boundary-or landmark-based. Similarly, earlier human and rodent experiments used this first trial after learning to determine per participant which memory system has been used (Schwabe et al, 2008a).…”

Section: Spatial Memory Task and Virtual Environmentmentioning

confidence: 99%

Stress Induces a Shift Towards Striatum-Dependent Stimulus-Response Learning via the Mineralocorticoid Receptor

Vogel

Klumpers

Schröder

et al. 2016

Neuropsychopharmacol

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Stress is assumed to cause a shift from flexible 'cognitive' memory to more rigid 'habit' memory. In the spatial memory domain, stress impairs place learning depending on the hippocampus whereas stimulus-response learning based on the striatum appears to be improved. While the neural basis of this shift is still unclear, previous evidence in rodents points towards cortisol interacting with the mineralocorticoid receptor (MR) to affect amygdala functioning. The amygdala is in turn assumed to orchestrate the stress-induced shift in memory processing. However, an integrative study testing these mechanisms in humans is lacking. Therefore, we combined functional neuroimaging of a spatial memory task, stress-induction, and administration of an MR-antagonist in a full-factorial, randomized, placebo-controlled between-subjects design in 101 healthy males. We demonstrate that stress-induced increases in cortisol lead to enhanced stimulusresponse learning, accompanied by increased amygdala activity and connectivity to the striatum. Importantly, this shift was prevented by an acute administration of the MR-antagonist spironolactone. Our findings support a model in which the MR and the amygdala play an important role in the stress-induced shift towards habit memory systems, revealing a fundamental mechanism of adaptively allocating neural resources that may have implications for stress-related mental disorders.

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“…********************* Figure 3 about here please ********************* (Schwabe et al, 2008;Shore et al, 2001).…”

Section: Hormonal Contribution To Affective Psychopathologies Across mentioning

confidence: 99%

Assessing gonadal hormone contributions to affective psychopathologies across humans and animal models

Mueller

Grissom

Dohanich

2014

Psychoneuroendocrinology

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Despite increasing acknowledgement of hormonal contributions to mood and anxiety disorders, the underlying mechanisms by which gonadal hormones influence psychopathology-related behaviours remain unknown. This review focuses on recent research that examines the influence of gonadal steroid hormones, including androgens, estrogens, and progesterone, on mood and anxiety-related behaviours in human health and disease. To this aim, the literature was surveyed for studies that assess conditions with suspected underlying hormonal imbalances in otherwise healthy participants (e.g., Premenstrual Dysphoric Disorder, Postmenopausal Depression,) as well as conditions linked to congenital endocrine abormalities (e.g., Turner Syndrome, Klinefelter Syndrome, Polycystic Ovary Syndrome, Congenital Adrenal Hyperplasia, Familial Male Precocious Puberty, Androgen Insensitivity Syndrome). Furthermore, to better inform clinical work and to create a translational bridge, a second goal was to set human psychopathologies and animal models of these conditions side-by-side. In the second part of the review, based on consistencies revealed in the existing literature across conditions, a new model for the impact of gonadal hormones on anxious and depressed behavioural states is proposed. Finally, we conclude by proposing directions for future research, including the development of specific tasks suitable for cross-species comparisons to increase our knowledge of the role of gonadal hormones in mood and anxiety.

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Chronic stress modulates the use of spatial and stimulus-response learning strategies in mice and man

Cited by 201 publications

References 44 publications

Stress and estrous cycle affect strategy but not performance of female C57BL/6J mice

Stress and estrous cycle affect strategy but not performance of female C57BL/6J mice

Stress Induces a Shift Towards Striatum-Dependent Stimulus-Response Learning via the Mineralocorticoid Receptor

Assessing gonadal hormone contributions to affective psychopathologies across humans and animal models

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