Chronic Systemic Curcumin Administration Antagonizes Murine Sarcopenia and Presarcopenia

Gorza, Luisa; Germinario, Elena; Tibaudo, Lucia; Vitadello, Maurizio; Tusa, Chiara; Guerra, Irene; Bondı̀, Michela; Salmaso, Stefano; Caliceti, Paolo; Vitiello, Libero; Danieli‐Betto, Daniela

doi:10.3390/ijms222111789

Cited by 13 publications

(25 citation statements)

References 57 publications

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“…Furthermore, in older subjects, curcumin may promote the optimal microvascular perfusion of skeletal muscles [ 257 ]. Multiple studies conducted in animal models of sarcopenia have shown that oral administration of curcumin is associated with the reduction of muscle wasting and improvements in markers of inflammation and oxidative stress [ 258 , 259 ]. Similar effects were also obtained with parenteral administration [ 260 ].…”

Section: Interaction Between Phenolic Compounds and Microbiota: Possi...mentioning

confidence: 99%

Accounting Gut Microbiota as the Mediator of Beneficial Effects of Dietary (Poly)phenols on Skeletal Muscle in Aging

et al. 2023

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Sarcopenia, the age-related loss of muscle mass and function increasing the risk of disability and adverse outcomes in older people, is substantially influenced by dietary habits. Several studies from animal models of aging and muscle wasting indicate that the intake of specific polyphenol compounds can be associated with myoprotective effects, and improvements in muscle strength and performance. Such findings have also been confirmed in a smaller number of human studies. However, in the gut lumen, dietary polyphenols undergo extensive biotransformation by gut microbiota into a wide range of bioactive compounds, which substantially contribute to bioactivity on skeletal muscle. Thus, the beneficial effects of polyphenols may consistently vary across individuals, depending on the composition and metabolic functionality of gut bacterial communities. The understanding of such variability has recently been improved. For example, resveratrol and urolithin interaction with the microbiota can produce different biological effects according to the microbiota metabotype. In older individuals, the gut microbiota is frequently characterized by dysbiosis, overrepresentation of opportunistic pathogens, and increased inter-individual variability, which may contribute to increasing the variability of biological actions of phenolic compounds at the skeletal muscle level. These interactions should be taken into great consideration for designing effective nutritional strategies to counteract sarcopenia.

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Section: Interaction Between Phenolic Compounds and Microbiota: Possi...mentioning

confidence: 99%

Accounting Gut Microbiota as the Mediator of Beneficial Effects of Dietary (Poly)phenols on Skeletal Muscle in Aging

et al. 2023

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“…Curcumin supplementation also resulted in decreased muscle soreness (visual analogue scale (VAS) 2.88), when compared with placebo (VAS 3.36, p = 0.012). No differences were observed in TAC, TNF, or MDA [ 127 ]. In a study by Hillman et al the authors aimed to determine the effects of curcumin supplementation on delayed onset muscle soreness and muscle power following plyometric exercise.…”

Section: Nutraceuticals With Anti-inflammatory Properties and Their P...mentioning

confidence: 99%

The role of nutraceuticals in heart failure muscle wasting as a result of inflammatory activity. The International Lipid Expert Panel (ILEP) Position Paper.

et al. 2023

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Muscle wasting is one of the main causes for exercise intolerance and ventilatory inefficiency in patients with heart failure and a strong predictor of frailty and reduced survival. The prevalence of sarcopenia is at least 20% in patients with heart failure. Patients with heart failure often have subclinical systemic inflammation, which may exert sustained effects on skeletal muscle. Besides exercise, nutrition should also be carefully evaluated, as an appropriate diet with selected nutraceuticals may be able to stimulate muscle anabolism and inhibit muscle catabolism. This review summarizes the epidemiological and clinical trial evidence supporting the recommendations for the use of nutraceuticals with anti-inflammatory properties in heart failure and provides an overview of the state of the evidence for nutraceutical supplementation to prevent and/or mitigate heart failure muscle wasting.

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“…Curcumin is also being associated with the prevention of age-related sarcopenia. Gorza et al [ 52 ] evaluated the effect of curcumin treatment at 120 µg/kg in a volume of 100 µL in 18-month-old C57BL6J and C57BL10ScSn male mice. In this study, the researchers observed that curcumin was able to significantly increase survival in both strains, preventing sarcopenia and pre-sarcopenia, preserving type-1 myofibers, and increasing type-2A ones, positively influencing the satellite cells by preserving adult levels of myofiber maturation in old, regenerating soleus muscle.…”

Section: Curcuminmentioning

confidence: 99%

Phytochemicals in Skeletal Muscle Health: Effects of Curcumin (from Curcuma longa Linn) and Sulforaphane (from Brassicaceae) on Muscle Function, Recovery and Therapy of Muscle Atrophy

Vargas-Mendoza

Madrigal-Santillán

Álvarez-González

et al. 2022

Plants

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The mobility of the human body depends on, among other things, muscle health, which can be affected by several situations, such as aging, increased oxidative stress, malnutrition, cancer, and the lack or excess of physical exercise, among others. Genetic, metabolic, hormonal, and nutritional factors are intricately involved in maintaining the balance that allows proper muscle function and fiber recovery; therefore, the breakdown of the balance among these elements can trigger muscle atrophy. The study from the nutrigenomic perspective of nutritional factors has drawn wide attention recently; one of these is the use of certain compounds derived from foods and plants known as phytochemicals, to which various biological activities have been described and attributed in terms of benefiting health in many respects. This work addresses the effect that the phytochemicals curcumin from Curcuma longa Linn and sulforaphane from Brassicaceae species have shown to exert on muscle function, recovery, and the prevention of muscle atrophy, and describes the impact on muscle health in general. In the same manner, there are future perspectives in research on novel compounds as potential agents in the prevention or treatment of medical conditions that affect muscle health.

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Chronic Systemic Curcumin Administration Antagonizes Murine Sarcopenia and Presarcopenia

Cited by 13 publications

References 57 publications

Accounting Gut Microbiota as the Mediator of Beneficial Effects of Dietary (Poly)phenols on Skeletal Muscle in Aging

Accounting Gut Microbiota as the Mediator of Beneficial Effects of Dietary (Poly)phenols on Skeletal Muscle in Aging

The role of nutraceuticals in heart failure muscle wasting as a result of inflammatory activity. The International Lipid Expert Panel (ILEP) Position Paper.

Phytochemicals in Skeletal Muscle Health: Effects of Curcumin (from Curcuma longa Linn) and Sulforaphane (from Brassicaceae) on Muscle Function, Recovery and Therapy of Muscle Atrophy

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