Chronic tinnitus and the limbic system: Reappraising brain structural effects of distress and affective symptoms

Besteher, Bianca; Gaser, Christian; Ivanšić, Daniela; Guntinas‐Lichius, Orlando; Dobel, Christian; Nenadić, Igor

doi:10.1016/j.nicl.2019.101976

Cited by 52 publications

(59 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“… 54 Brain structural changes in both the auditory and limbic systems were recently revealed with the help of high-resolution structural MRI, reiterating the importance of the connection between the auditory and nonauditory brain networks in tinnitus. 55 …”

Section: Tinnitus Mechanismsmentioning

confidence: 99%

Tinnitus Update

Han¹,

Lee

Ryu

et al. 2021

J Clin Neurol

View full text Add to dashboard Cite

This article provides an update on tinnitus for audiologists and other clinicians who provide tinnitus-specific services. Tinnitus can be attributable to hearing loss, somatosensory system dysfunction, or auditory cortex dysfunction, with hearing loss being the most common cause and serious underlying pathologies being rare. Hearing loss does not always lead to tinnitus, and patients with tinnitus do not always suffer from hearing loss. The first scenario is explained by a so-called inhibitory gating mechanism, whereas the second assumes that all tinnitus sufferers have some degree of hearing impairment, which might not be detected in standard audiological examinations. The treatments should aim at symptomatic relief and management of associated distress. Current treatment options include pharmacotherapy, education, counseling, cognitive behavioral therapy, and sound therapy.

show abstract

Section: Tinnitus Mechanismsmentioning

confidence: 99%

Tinnitus Update

Han¹,

Lee

Ryu

et al. 2021

J Clin Neurol

View full text Add to dashboard Cite

show abstract

“…It is generally believed that tinnitus is not only the result of a cochlear lesion, but also a symptom involving plasticity of the central nervous system (Chen et al, 2016; Lanting, De, & Van, 2009; Loo et al, 2009). Recent studies have found that abnormal central reorganization in subjective chronic tinnitus involves auditory and nonauditory brain areas such as the frontal cortex, parahippocampal gyrus, caudate nucleus, cingulate cortex, and insula (Araneda et al, 2018; Besteher et al, 2019; De et al, 2014; Elgoyhen, Langguth, Ridder, & Vanneste, 2015; Henderson‐Sabes et al, 2019; Schlee et al, 2009; Vanneste, Alsalman, & De Ridder, 2018; Xu et al, 2019), and that these central neural changes were possible contributors to the clinical symptoms of tinnitus, for example, impairment of perception, cognition, attention, memory, and emotion (Besteher et al, 2019; Chen et al, 2017; De, Elgoyhen, Romo, & Langguth, 2011; Husain, 2016; Joos, Vanneste, & De Ridder, 2012; Pattyn et al, 2016; Vanneste, To, & De Ridder, 2019). For example, Schlee et al (Schlee et al, 2009) found that abnormal activation of the frontal cortex was related to a conscious perception of subjective chronic tinnitus and Vanneste et al (Vanneste & De Ridder, 2016) found that the parahippocampal area was significantly activated in chronic tinnitus patients with severe hearing loss.…”

Section: Introductionmentioning

confidence: 99%

Alterations of brain activity and functional connectivity in transition from acute to chronic tinnitus

Lan

Chen

et al. 2020

Human Brain Mapping

View full text Add to dashboard Cite

The objective of this study was to investigate alterations to brain activity and functional connectivity in patients with tinnitus, exploring neural features in the transition from acute to chronic phantom perception. Twenty-four patients with acute tinnitus, 23 patients with chronic tinnitus, and 32 healthy controls were recruited. Highdensity electroencephalography (EEG) was used to explore changes in brain areas and functional connectivity in different groups. When compared with healthy subjects, acute tinnitus patients had a significant reduction in superior frontal cortex activity across all frequency bands, whereas chronic tinnitus patients had a significant reduction in the superior frontal cortex at beta 3 and gamma frequency bands as well as a significant increase in the inferior frontal cortex at delta-band and superior temporal cortex at alpha 1 frequency band. When compared to the chronic tinnitus group, the acute tinnitus group activity was significantly increased in the middle frontal and parietal gyrus at the gamma-band. Functional connectivity analysis showed that the chronic tinnitus group had increased connections between the parahippocampus gyrus, posterior cingulate cortex, and precuneus when compared with the healthy group. Alterations of local brain activity and connections between the parahippocampus gyrus and other nonauditory areas appeared in the transition from acute to chronic tinnitus. This indicates that the appearance and development † Liping Lan and Jiahong Li contributed equally to this work.

show abstract

“…Indeed, microstructural changes in the brain have also been reported in some tinnitus studies (21,22).…”

Section: Introductionmentioning

confidence: 61%

Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Combined VBM and SCN Study

Qian

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Many neuroanatomical alterations have been detected in patients with tinnitus in previous studies. However, little is known about morphological and structural covariance network (SCN) changes before and after long-term sound therapy. This study aimed to explore alterations in brain anatomical and SCN changes in patients with idiopathic tinnitus using voxel-based morphometry (VBM) analysis 24 weeks before and after sound therapy. Methods: Thirty-three tinnitus patients underwent magnetic resonance imaging scans at baseline and after 24 weeks of sound therapy. Twenty-six age- and sex-matched healthy control (HC) individuals also underwent two scans over a 24-week interval; 3.0T MRI and high-resolution 3D structural images were acquired with a 3D-BRAVO pulse sequence. Structural image data preprocessing was performed using the VBM8 toolbox. The Tinnitus Handicap Inventory (THI) score was acquired in the tinnitus group to assess the severity of tinnitus and tinnitus-related distress. Two-way mixed model analysis of variance (ANOVA) and post hoc analyses were performed to determine differences between the two groups (patients and HCs) and between the two scans (at baseline and at the 24th week). Two-sample t tests, paired-samples t tests, and Pearson’s correlation analysis were used in the post hoc analysis.Results: Interaction effects between the two groups and the two scans demonstrated significantly different gray matter (GM) volume in the right parahippocampus gyrus, right caudate, left superior temporal gyrus, left cuneus gyrus and right calcarine gyrus; we found significantly decreased GM volume in the above five brain regions among the tinnitus patients before sound therapy (baseline) compared to that in the HC group. The 24-week sound therapy group demonstrated significantly greater brain volume compared with the baseline group among these brain regions. We did not find significant differences in brain regions between the 24-week sound therapy and HC groups. The SCN results showed that the left superior temporal gyrus and left rolandic operculum were significantly different in nodal efficiency, nodal degree centrality and nodal betweenness centrality after FDR correction. Decreased THI scores and GM volume changes between the left thalamus and right thalamus were not correlated. Conclusions: This study characterized the effect of sound therapy on brain GM volume, especially in the left superior temporal lobe. Notably, sound therapy had a normalizing effect on tinnitus patients.

show abstract

Chronic tinnitus and the limbic system: Reappraising brain structural effects of distress and affective symptoms

Cited by 52 publications

References 77 publications

Tinnitus Update

Tinnitus Update

Alterations of brain activity and functional connectivity in transition from acute to chronic tinnitus

Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Combined VBM and SCN Study

Contact Info

Product

Resources

About