Chronic toxicity of nanodiamonds can disturb development and reproduction of Acheta domesticus L

Karpeta-Kaczmarek, Julia; Kędziorski, Andrzej; Augustyniak, Maria; Dziewięcka, Marta

doi:10.1016/j.envres.2018.05.027

Cited by 32 publications

(19 citation statements)

References 46 publications

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“…In a recent study by Karpeta-Kaczmarek et al [65], a female cricket Acheta domesticus that fed on nanodiamonds was found to produce fewer eggs compared to controls. The authors suggested that the nanodiamonds deteriorated the digestion and/or assimilation, which in turn depleted the usable energy resources that can be incorporated in reproduction.…”

Section: Plos Onementioning

confidence: 94%

Relative expression of microRNAs, apoptosis, and ultrastructure anomalies induced by gold nanoparticles in Trachyderma hispida (Coleoptera: Tenebrionidae)

et al. 2020

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The extensive use of nanomaterials generates toxic effects on non-target species and the ecosystem. Although gold nanoparticles (Au-NPs) are generally expected to be safe, the recent study contains conflicting data regarding their cytotoxicity in the darkling beetles Trachyderma hispida. The study postulated cellular perturbation in the ovarian tissue of the beetles induced by a sublethal dose of Au-NPs (0.01 mg/g). When compared with the controls, a significant inhibition in the activities of the antioxidant enzymes selenium-dependent (GPOX) and selenium-independent (GSTP) glutathione peroxidases (GPx) was observed in the treated beetles. The study proposed microRNAs (miRNA-282 and miRNA-989) as genotoxic markers for the first time, reporting a significant suppression in their transcriptional levels in the treated beetles. Furthermore, TUNEL (Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling) and flow cytometry assays (annexin V-Fitc) indicated a significant increase in ovarian cell apoptosis in the treated beetles. Additionally, an ultrastructure examination revealed pathological changes in the ovarian cells of the treated beetles. The resulting anomalies in the present study may interrupt the fecundity of the beetles and lead to the future suppression of beetle populations.

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Section: Plos Onementioning

confidence: 94%

Relative expression of microRNAs, apoptosis, and ultrastructure anomalies induced by gold nanoparticles in Trachyderma hispida (Coleoptera: Tenebrionidae)

et al. 2020

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“…In most in vivo studies of ND cytotoxicity in animal models, this nanoparticle has been administered orally or by injection 5,38,39 . The in vitro permeability of NDs through the skin has been studied, and these nanoparticles are recommended as an excellent topical drug delivery system, especially for oxidation- and light-sensitive drugs, due to their improved permeability, higher stability, and minimal safety issues 40 .…”

Section: Discussionmentioning

confidence: 99%

“…Due to the excellent physical and chemical properties of nanodiamonds (NDs), such as their small size, hardness, large surface area, high absorption capacity and chemical stability, various ND applications in the field of nanobiotechnology have been proposed (e.g., drug delivery, use as biosensors and in bioimaging and coating of implants) 1–4 . NDs are considered biocompatible; however, the biomedical use of these nanoparticles is now being discussed because some recent works have shown the adverse effects of NDs on insect, chicken embryo, mouse and rat cells 2,5–9 . However, few studies have focused on ND cytotoxicity in animal models in vivo 2,5,10–15 .…”

Section: Introductionmentioning

confidence: 99%

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Impairment of the immune response after transcuticular introduction of the insect gonadoinhibitory and hemocytotoxic peptide Neb-colloostatin: A nanotech approach for pest control

Czarniewska

Nowicki

Kuczer

et al. 2019

Sci Rep

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This article shows that nanodiamonds can transmigrate through the insect cuticle easily, and the doses used were not hemocytotoxic and did not cause inhibition of cellular and humoral immune responses in larvae, pupae and adults of Tenebrio molitor . The examination of the nanodiamond biodistribution in insect cells demonstrated the presence of nanodiamond aggregates mainly in hemocytes, where nanoparticles were efficiently collected as a result of phagocytosis. To a lesser extent, nanodiamond aggregates were also detected in fat body cells, while they were not observed in Malpighian tubule cells. We functionalized nanodiamonds with Neb -colloostatin, an insect hemocytotoxic and gonadoinhibitory peptide, and we showed that this conjugate passed through the insect cuticle into the hemolymph, where the peptide complexed with the nanodiamonds induced apoptosis of hemocytes, significantly decreased the number of hemocytes circulating in the hemolymph and inhibited cellular and humoral immune responses in all developmental stages of insects. The results indicate that it is possible to introduce a peptide that interferes with the immunity and reproduction of insects to the interior of the insect body by means of a nanocarrier. In the future, the results of these studies may contribute to the development of new pest control agents.

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“…Multiple options for surface modification of nanodiamonds, as well as their carbon-based nature, emerge, the attention focusing toward their toxicity. It has been proposed from in vivo studies that induction of oxidative stress that may accompany long-term exposure to NDs is responsible, at least in part, for their toxicity [ 108 , 109 ]. For example, Dworak and coworkers demonstrated that NDs-mediated oxidative stress may contribute to DNA damage on lymphocytes, which is susceptible to prolonged treatment to NDs [ 110 ].…”

Section: Biological Effects Of Carbon Nanomaterialsmentioning

confidence: 99%

The Puzzling Potential of Carbon Nanomaterials: General Properties, Application, and Toxicity

et al. 2020

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Being a member of the nanofamily, carbon nanomaterials exhibit specific properties that mostly arise from their small size. They have proved to be very promising for application in the technical and biomedical field. A wide spectrum of use implies the inevitable presence of carbon nanomaterials in the environment, thus potentially endangering their whole nature. Although scientists worldwide have conducted research investigating the impact of these materials, it is evident that there are still significant gaps concerning the knowledge of their mechanisms, as well as the prolonged and chronic exposure and effects. This manuscript summarizes the most prominent representatives of carbon nanomaterial groups, giving a brief review of their general physico-chemical properties, the most common use, and toxicity profiles. Toxicity was presented through genotoxicity and the activation of the cell signaling pathways, both including in vitro and in vivo models, mechanisms, and the consequential outcomes. Moreover, the acute toxicity of fullerenol, as one of the most commonly investigated members, was briefly presented in the final part of this review. Thinking small can greatly help us improve our lives, but also obliges us to deeply and comprehensively investigate all the possible consequences that could arise from our pure-hearted scientific ambitions and work.

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Chronic toxicity of nanodiamonds can disturb development and reproduction of Acheta domesticus L

Cited by 32 publications

References 46 publications

Relative expression of microRNAs, apoptosis, and ultrastructure anomalies induced by gold nanoparticles in Trachyderma hispida (Coleoptera: Tenebrionidae)

Relative expression of microRNAs, apoptosis, and ultrastructure anomalies induced by gold nanoparticles in Trachyderma hispida (Coleoptera: Tenebrionidae)

Impairment of the immune response after transcuticular introduction of the insect gonadoinhibitory and hemocytotoxic peptide Neb-colloostatin: A nanotech approach for pest control

The Puzzling Potential of Carbon Nanomaterials: General Properties, Application, and Toxicity

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