Chronic toxicity studies of analgesic and antipyretic drugs and congeners

Wright, Harold N.

doi:10.1016/0041-008x(67)90071-3

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Acetaminophen1

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1977

1989

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Cited by 17 publications

(1 citation statement)

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“…Also, long-term acetaminophen administra¬ tion reduced fecundity in mice. 56 Although salicylates interfere with fetal growth and development, acet-aminophen given in doses of 125 and 250 mg/kg/day to pregnant rats had no effect on fetal or placental growth.57…”

Section: Acetaminophenmentioning

confidence: 99%

Effects of Aspirin and Acetaminophen in Pregnancy and in the Newborn

Rudolph¹

1981

Arch Intern Med

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Section: Acetaminophenmentioning

confidence: 99%

Effects of Aspirin and Acetaminophen in Pregnancy and in the Newborn

Rudolph¹

1981

Arch Intern Med

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Effects of aspirin and acetaminophen in pregnancy and in the newborn

Rudolph¹

1981

Archives of Internal Medicine

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Inhibitors of prostaglandin synthesis are increasingly recommended for delaying premature delivery. However, such inhibitors--eg, aspirin, indomethacin, or naproxen--may interfere with uterine contractility, with maternal, fetal, and neonatal platelet function, and especially with fetal circulation and postnatal adaptation. The instillation of aspirin (50 to 90 mg/kg of fetal body weight) into the rumina of fetal lambs resulted in significant increase of pulmonary arterial pressure, which was directly related to constriction of the ductus arteriosus. Such pressure elevation may act as a stimulus to increased muscular development in the small vessels of the lung, which, in turn, could interfere with the rapid reduction in pulmonary vascular resistance normally occurring after birth. The effects of acetaminophen in pregnancy and in the newborn have not been studied extensively; when ingested in usual therapeutic doses, the available data have shown no adverse effects.

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Effects of Aspirin and Acetaminophen on Fetal and Placental Growth in Rats

Lubawy

Garrett

1977

Journal of Pharmaceutical Sciences

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Chronic toxicity studies of analgesic and antipyretic drugs and congeners

Cited by 17 publications

References 6 publications

Effects of Aspirin and Acetaminophen in Pregnancy and in the Newborn

Effects of Aspirin and Acetaminophen in Pregnancy and in the Newborn

Effects of aspirin and acetaminophen in pregnancy and in the newborn

Effects of Aspirin and Acetaminophen on Fetal and Placental Growth in Rats

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