Chronic toxicity study of &lt;i&gt;Ficus platyphtlla&lt;/i&gt; blume in rats

Onyeyilli, P.; Iwuoha, C.L; Akinniyi, John A.

doi:10.4314/wajpdr.v14i1.53414

Cited by 11 publications

(11 citation statements)

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“…According to Onyenyili and co-workers [15], anaemia following administration of an agent can be as a result of lysis of blood cells and/or inhibition of blood cell synthesis by the active constituents of the extract, and decrease in hematological parameters in experimental animals has been associated with anemia [16]. There was no significant change in haematological parameters in the extracts-treated animals compared to the control (Table 2), which indicates that there is no lysis of blood cells and/or inhibition in blood cells synthesis by the active constituents of C. pentandra extract.…”

Section: Subacute Toxicity Studiesmentioning

confidence: 99%

Acute and Subacute Toxicity Study of Methanolic Extract of <i>ceiba pentandra</i> (Linn.) Gaertn. on Rats

Gandhare¹,

Kavimani

Balasubramanian

2013

J. Sci. Res.

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The purpose of toxicity testing is to provide adequate database to make decisions concerning the toxicology properties of chemical and commercial products. In some situations, the purpose is to decide whether a material will be safe. Under the conditions of expected use in other situations, the objective is to establish the safe limits in condition of use. The methanolic extract of ceiba pentandra was evaluated for acute and subacute toxicity in adult Wistar rats. For the study of acute toxicity, the methanol extract of roots of C. pentandra (MCP) was given separately in various doses (50, 500, 1000, 2000 mg/kg) by oral route. The results showed no signs of toxicity such as general behavior change, mortality, or change in gross appearance of internal organs. Subacute toxicity was studied by daily oral doses 100, 400 and 750 mg/kg (low dose, intermediate dose and high dose) orally for 28 days. The results showed no abnormalities in treated groups as compared to the controls. Although significantly different, all of the values were within normal limits. Neither gross abnormalities nor histopathological changes were observed.

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Section: Subacute Toxicity Studiesmentioning

confidence: 99%

Acute and Subacute Toxicity Study of Methanolic Extract of <i>ceiba pentandra</i> (Linn.) Gaertn. on Rats

Gandhare¹,

Kavimani

Balasubramanian

2013

J. Sci. Res.

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“…Again, lyses of blood cells, inhibition of blood cells synthesis and or significant alterations in haematological parameters have been associated with anaemia especially, following the administration of a toxic agent. 14,15 From our results, TAE did not cause any significant changes in the haematological parameters analysed indicating it may not have toxic effects on the haematological parameters. Moreover, marked changes in the levels of biochemical parameters such as total protein, albumin, bilirubin, AST, ALT, GGT and ALP are used to detect abnormal functioning liver or the presence of hepatocellular damage.…”

Section: -11mentioning

confidence: 60%

Pentobarbitone-induced sleeping time and sub-acute toxicity studies of Trichilia monadelpha aqueous extract

Owusu

Antwi-Adjei

Henneh

2016

Int J Basic Clin Pharmacol

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“…Indeed, this fraction content flavonoids, molecules known as being hepatoprotectrice 16 . The effect of this plant on the liver would be due to the presence of flavonoids.…”

Section: Effect Of X 42 On Hematological Parametersmentioning

confidence: 99%

“…Moreover, anemia following administration of an agent can be as a result of lysis of blood cells and/or inhibition of blood cell synthesis by the active constituents of the extract, and decrease in hematological parameters in experimental animals has been associated with anemia 16 . It was found that, the plant extract did not affect the haematograms of the rats in a manner that would suggest adverse effects on their bone marrow, which is a source of recticulocytes.…”

Section: Effect Of X 42 On Hematological Parametersmentioning

confidence: 99%

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2018

IJPSR

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ABSTRACT:The present work focuses to check the acute and sub-acute toxicity studies of X 42 fraction of Terminalia ivorensis in rats. Materials and methods: The acute toxicity of the extract was evaluated in rats. The rats were administered intraperitoneally the fraction at the dose of 50, 100, 200 and 300 mg/kg bw and recorded general symptoms and mortality. For sub acute toxicity, the rats received intraperitoneally, normal saline (control), 2.5; 5.0 and 10.0 mg/kg of the extract for 28 days. Animals were observed for general behavioral and signs of abnormalities during the experiment duration. The last day, blood was taken for hematological and biochemical analysis. The liver, kidney, and heart tissues were weighed. Results: Acute toxicity study produced dose dependent mortality with median Lethal Dose (LD 50 ) of 200 mg/kg. Repeated administration of fraction caused no mortality. There were no significant changes (p>0.05) observed in serum biochemical markers, hematological markers, body weight changed, relative organs weight when compared to control group. Conclusion: The results show that the extract of T. ivorensis is moderately toxic when given intraperitoneally.

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Chronic toxicity study of <i>Ficus platyphtlla</i> blume in rats

Cited by 11 publications

References 0 publications

Acute and Subacute Toxicity Study of Methanolic Extract of <i>ceiba pentandra</i> (Linn.) Gaertn. on Rats

Acute and Subacute Toxicity Study of Methanolic Extract of <i>ceiba pentandra</i> (Linn.) Gaertn. on Rats

Pentobarbitone-induced sleeping time and sub-acute toxicity studies of Trichilia monadelpha aqueous extract

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