Chronic traffic noise stress accelerates brain impairment and cognitive decline in mice

Jafari, Zahra; Kolb, Bryan; Mohajerani, Majid H.

doi:10.1016/j.expneurol.2018.06.011

Cited by 90 publications

(75 citation statements)

References 85 publications

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“…In particular, we included age, sex, body-mass index, overall health, alcohol use, smoking, educational attainment, and socioeconomic status because these have been associated with cognitive decline (Baumgart et al, 2015;Marden et al, 2017), and we anticipated similar confounding for hippocampal volume. We also included inverse distance from the nearest major road (Khan et al, 2018) because noise pollution from transportation is associated with adverse health outcomes, such as ischemic heart disease (Vienneau et al, 2015) and diabetes (Clark et al, 2017), and because in a murine model exposure to traffic noise resulted in brain changes including a reduction in hippocampal volume (Jafari et al, 2018). To control for head size and total brain volume, we included a measure of total brain volume (white matter plus gray matter normalized for head size) (Alfaro-Almagro et al, 2018).…”

Section: Covariatesmentioning

confidence: 99%

Association between exposure to air pollution and hippocampal volume in adults in the UK Biobank

et al. 2019

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Background: The hippocampus is important for memory processing. Several neuropsychiatric diseases including Alzheimer's disease are associated with reduced hippocampal volume, and further the hippocampus appears vulnerable to environmental insult. Air pollution has been associated with cardiovascular disease, abnormal brain structure, and cognitive deficits. Objective: Because of hippocampal vulnerability to environmental insults and based on the association between exposure to air pollution and cognitive function and brain structure, we evaluated the association between exposure to toxins in air pollution and left and right hippocampal volume using brain-imaging and air-pollution data from the UK Biobank, a large community-based dataset. Methods: We used regression modelling to evaluate the association between exposure to nitrogen dioxide, nitrogen oxides, PM 2.5 , PM 2.5-10 , and PM 10. and left and right hippocampal volume controlling for age, sex, bodymass index, overall health, alcohol use, smoking, educational attainment, socioeconomic status, inverse distance from the nearest major road, and a measure of total brain volume. Results: In these models, PM 2.5 concentration was associated with smaller left hippocampal volume. None of the other measures of air pollution was associated with either left or right hippocampal volume, although interaction models provided some evidence that sex might moderate the relationship between air pollution and hippocampal volume. In adjusted models, age, sex, educational attainment, income, overall health, current smoking, alcohol intake, and body-mass index were associated with hippocampal volume. Conclusions: PM 2.5 at levels found in the United Kingdom was associated with smaller left hippocampal volume. Additional associations between several covariates and hippocampal volumes indicate that hippocampal volume might be associated with several potentially modifiable variables.

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Section: Covariatesmentioning

confidence: 99%

Association between exposure to air pollution and hippocampal volume in adults in the UK Biobank

et al. 2019

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“…Noise can affect cognitive function through altered hippocampal signaling, as suggested by animal studies (reviewed in [8]). In an animal study, day- and nighttime traffic noise exposure caused the hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, anxiety behavior, worse learning, memory, and coordination; it also affected the brain measures [28]. Noise-triggered activation of the HPA axis, measured as the concentration of its product cortisol, was observed in a panel study with healthy male volunteers [29].…”

Section: Discussionmentioning

confidence: 99%

Road Traffic Noise at the Residence, Annoyance, and Cognitive Function in Elderly Women

Fuks

Wigmann

Altuğ

et al. 2019

IJERPH

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The detrimental effects of traffic noise on cognition in children are well documented. Not much is known about the health effects in adults. We investigated the association of residential exposure to road traffic noise and annoyance due to road traffic noise with cognitive function in a cohort of 288 elderly women from the longitudinal Study on the influence of Air pollution on Lung function, Inflammation and Aging (SALIA) in Germany. Residential noise levels—weighted 24-h mean (LDEN) and nighttime noise (LNIGHT)—were modeled for the most exposed facade of dwellings and dichotomized at ≥50 dB(A). Traffic noise annoyance (day and night) was estimated by questionnaire. Cognitive function was assessed using the Consortium to Establish a Registry on Alzheimer’s Disease (CERAD-Plus) Neuropsychological Assessment Battery. The modeled noise levels were associated with impaired total cognition and the constructional praxis domain, independently of air pollution. Self-reported noise annoyance was associated with better performance in semantic memory and constructional praxis domains. This finding should be interpreted with caution since we could not control for potential confounding by hearing loss. Noise levels and annoyance were associated, but their health effects seemed mutually independent.

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“…Moreover, reduced neurogenesis is associated with deficits on learning and memory tasks [139][140][141]. Furthermore, even when animals are exposed to seemingly safe noise levels (75 dB LAeq, 8 h ) for extended periods, they can display poorer performance on learning and memory tasks [142]. Similar to the theories of noise-induced CVDs, noise-induced consequences on learning, memory, and brain function could also be mediated by the altered stress responses, given that noise-induced hearing loss upregulates glucocorticoid receptors in the hippocampus, a critical component of the negative feedback network in the HPA axis [143].…”

Section: Cognitionmentioning

confidence: 99%

Occupational Noise: Auditory and Non-Auditory Consequences

Sheppard¹,

Ralli

Gilardi

et al. 2020

IJERPH

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Occupational noise exposure accounts for approximately 16% of all disabling hearing losses, but the true value and societal costs may be grossly underestimated because current regulations only identify hearing impairments in the workplace if exposures result in audiometric threshold shifts within a limited frequency region. Research over the past several decades indicates that occupational noise exposures can cause other serious auditory deficits such as tinnitus, hyperacusis, extended high-frequency hearing loss, and poor speech perception in noise. Beyond the audiogram, there is growing awareness that hearing loss is a significant risk factor for other debilitating and potentially life-threatening disorders such as cardiovascular disease and dementia. This review discusses some of the shortcomings and limitations of current noise regulations in the United States and Europe.

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Chronic traffic noise stress accelerates brain impairment and cognitive decline in mice

Cited by 90 publications

References 85 publications

Association between exposure to air pollution and hippocampal volume in adults in the UK Biobank

Association between exposure to air pollution and hippocampal volume in adults in the UK Biobank

Road Traffic Noise at the Residence, Annoyance, and Cognitive Function in Elderly Women

Occupational Noise: Auditory and Non-Auditory Consequences

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