2021
DOI: 10.1111/ctr.14214
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Chronic transplant glomerulopathy: New insights into pathogenesis

Abstract: There have been recent significant advances in short‐term outcomes in renal transplantation, however, long‐term allograft survival remains a challenge. With reported incidences as high of 74.5% of chronic graft loss in patients with biopsies showing transplant glomerulopathy (TG), this syndrome represents an important factor for chronic allograft complications. In this review we show an overview of the novel mechanistic insights into pathogenesis of TG, as well as a brief description of the pathology, diagnosi… Show more

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Cited by 7 publications
(4 citation statements)
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“…To minimize relevant imbalances between trial arms, patients will undergo stratified randomization to reduce center bias and weight for ABMR phenotype (active versus chronic active ABMR). Stratification for the presence or absence of chronic injury (most prominently transplant glomerulopathy) was chosen to account for potential variability regarding the extent of chronic injury, which is well established to be a major predictor of graft outcome, critically influencing responsiveness to treatment [ 43 ]. Even with the use of surrogate endpoints, such as eGFR slope, which may effectively predict transplant survival, larger samples would be needed.…”
Section: Discussionmentioning
confidence: 99%
“…To minimize relevant imbalances between trial arms, patients will undergo stratified randomization to reduce center bias and weight for ABMR phenotype (active versus chronic active ABMR). Stratification for the presence or absence of chronic injury (most prominently transplant glomerulopathy) was chosen to account for potential variability regarding the extent of chronic injury, which is well established to be a major predictor of graft outcome, critically influencing responsiveness to treatment [ 43 ]. Even with the use of surrogate endpoints, such as eGFR slope, which may effectively predict transplant survival, larger samples would be needed.…”
Section: Discussionmentioning
confidence: 99%
“…The pathology of kidney biopsy can indicate non-specific features such as chronic immune damage, interstitial fibrosis or renal tubular atrophy ( Sayin et al, 2017 ). With the advancement of matching technology, surgical technology and the use of immunosuppressive agents, short-term outcome of kidney transplantation has been improved, but long-term outcome still remains a challenge ( Gokhale et al, 2021 ). How to reduce the occurrence of CAN is currently the most concerned issue.…”
Section: Clinical Applications and Mechanisms Of Twhf And Its Prepara...mentioning
confidence: 99%
“…It will be important to understand the pathobiology of xenograft failure to achieve the best possible outcomes. In renal allotransplantation, the most common cause of late graft failure is transplant glomerulopathy secondary to chronic AMR 9,10 …”
Section: Introductionmentioning
confidence: 99%