Chronic treatment with tocotrienol, an isoform of vitamin E, prevents intracerebroventricular streptozotocin-induced cognitive impairment and oxidative–nitrosative stress in rats

Tiwari, Vinod; Kuhad, Anurag; Bishnoi, Mahendra; Chopra, Kanwaljit

doi:10.1016/j.pbb.2009.05.009

Cited by 141 publications

(89 citation statements)

References 42 publications

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“…Therefore, cognitive impairment showed by diabetic rat was improved with the Tri-E ® supplementation. The finding in this study agreed to the previous studies [15,18,29,37,38]. However, supplementation with ATF showed no significance difference with the diabetic group.…”

Section: Asmara Et Alsupporting

confidence: 92%

Tri-E® Prevents Cognitive Impairment and Deoxyribonucleic Acid Damage in Diabetes Mellitus

Asmara

Latif

Faisal

et al. 2017

Asian J Pharm Clin Res

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Objective: The aim of the current study is to compare the difference of Tri-E ® and ATF potentials in reducing diabetic adverse event due to hyperglycemia that might cause the DNA damage and cognitive impairment indirectly. Methods: Diabetic model sample from Sprague Dawley was developed by combination of twice low-dose streptozotocin injection and high fat diet. The diabetic rat model was treated with Tri-E ® and ATF in different groups, control group were provided. The DNA was collected from the whole blood and DNA damage was measured using the comet assay method. While cognitive status was measured using Morris water-maze method. Result: Reduction of the DNA damage and improvement of cognitive function were observed in both ATF and Tri-E ® supplementations that elevated in diabetic. However, the DNA damage reduction by Tri-E ® was onefold higher compared to ATF supplementation. Conclusion: This study provided data that Tri-E ® has superior potential than ATF as a preventative agent to DNA damage and cognitive impairment in diabetes indirectly.

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Section: Asmara Et Alsupporting

confidence: 92%

Tri-E® Prevents Cognitive Impairment and Deoxyribonucleic Acid Damage in Diabetes Mellitus

Asmara

Latif

Faisal

et al. 2017

Asian J Pharm Clin Res

View full text Add to dashboard Cite

show abstract

“…Moreover, pre-treatment with vitamin E demonstrated antioxidant activity, observed as significantly enhanced GSH level and decreased level of thiobarbituric acid reactive substances (TBARS), associated with significant restoration of CAT activity in the hippocampus. These findings have been confirmed in another experiment which explored the effect of both isoforms of vitamin E, alpha-tocopherol and tocotrienol against STZ-icv induced cognitive impairment and oxidative-nitrosative stress in rats measured 3 weeks following the STZ-icv treatments (Tiwari et al 2009). Alpha-tocopherol as well as tocotrienol treated STZ-icv groups showed significantly less cognitive impairment in Morris Water Maze and Elevated plus maze tests but the effect was more potent with tocotrienol.…”

Section: Compounds With Predominant Antioxidative Activity Often Accmentioning

confidence: 68%

What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer’s disease, about the therapeutic strategies in Alzheimer’s research

et al. 2012

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“…Two heparinized polypropylene tubes of approximately 3 cm length were cannulated 3.6 mm deep into the brain and fitting exactly into the two burr holes made in the skull. A sham surgery was done by giving a cut in skin as before but without burr holes in the skull (Tiwari et al 2009;Kumar et al 2006a). The open end of cannula was closed; dental cement was applied, allowed to dry to fix the cannula with skull; the cut skin was sutured; and povidone iodine solution was applied.…”

Section: Surgery and Icv-stz Administrationmentioning

confidence: 99%

Neuroprotective Effect of Cyclooxygenase Inhibitors in ICV-STZ Induced Sporadic Alzheimer’s Disease in Rats

et al. 2011

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Sporadic Alzheimer's disease is an age-related neurological and psychiatric disorder characterized by impaired energy metabolism. Oxidative stress and neuroinflammation have been implicated in pathophysiology of sporadic type of dementia. The central streptozotocin administration induces behavioral and biochemical alterations resembling those in sporadic type of Alzheimer's patients. The present study was designed to investigate the effects of chronic pretreatment with cyclooxygenase-1 or cyclooxygenase-2 or cyclooxygenase-3 selective inhibitors on cognitive dysfunction and oxidative stress markers in intracerebroventricular streptozotocin-treated rats. Chronic treatment with valeryl salicylate (5 and 10 mg/kg, i.p.) and etoricoxib (5 and 10 mg/kg, i.p.) on a daily basis for a period of 21 days, beginning 1 h prior to first intracerebroventricular streptozotocin injection, significantly improved streptozotocin-induced cognitive impairment. However, phenacetin (20 and 40 mg/kg, i.p.) failed to restore the cognitive performances of streptozotocin-treated rats. Besides, improving cognitive dysfunction, chronic administration of highly selective cyclooxygenase-1 and/or cyclooxygenase-2 inhibitors (valeryl salicylate and etoricoxib, respectively), but not cyclooxygenase-3 inhibitor (phenacetin), significantly reduced elevated malondialdehyde, nitrite levels, and restored reduced glutathione and superoxide dismutase levels. Furthermore, cyclooxygenase-1 and/or cyclooxygenase-2 inhibitors significantly increased the survival of pyramidal neurons. In summary, we demonstrate for the first time that both cyclooxygenase-1 and cyclooxygenase-2 isoforms, but not cyclooxygenase-3, are involved in the progression of neuronal damage in intracerebroventricular streptozotocin-treated rats.

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Chronic treatment with tocotrienol, an isoform of vitamin E, prevents intracerebroventricular streptozotocin-induced cognitive impairment and oxidative–nitrosative stress in rats

Cited by 141 publications

References 42 publications

Tri-E® Prevents Cognitive Impairment and Deoxyribonucleic Acid Damage in Diabetes Mellitus

Tri-E® Prevents Cognitive Impairment and Deoxyribonucleic Acid Damage in Diabetes Mellitus

What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer’s disease, about the therapeutic strategies in Alzheimer’s research

Neuroprotective Effect of Cyclooxygenase Inhibitors in ICV-STZ Induced Sporadic Alzheimer’s Disease in Rats

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