Chronic ulcerative stomatitis: clinical, histopathologic, and immunopathologic findings

The diagnostic challenges of separating chronic ulcerative stomatitis from oral lichen planus

“…Histologically, both OLP and CUS illustrate classic atrophic epithelium, hydropic degeneration of the basal cell layer with cytoid bodies, and a band-like inflammatory infiltrate. 12,13 So far, the only consistently reliable method to establish a definitive diagnosis between the 2 lesions is through DIF. CUS demonstrates a speckled immunoglobulin (IgG) deposition in the nuclei of keratinocytes in the lower one-third of the epithelium, whereas OLP lacks IgG positivity, expressing instead a nonspecific linear pattern with fibrinogen along the basement membrane zone.…”

Diseases presenting with vesicular and erosive lesions of oral mucous membranes

“…It usually develops in women between 30 and 60 years of age [38]. The aetiopathogenesis of CUS has not been fully clarified yet, however the disease is most likely autoimmune in nature.…”

“…The aetiopathogenesis of CUS has not been fully clarified yet, however the disease is most likely autoimmune in nature. IgGclass squamous epitheliumspecific antinuclear antibodies (SESANA) are detected in the serum of patients, often in very high titres [38][39][40][41]. SESANA are directed against nuclear antigens of cells in the basal layer of stratified squamous epithelium.…”

“…Przewlekłe wrzodziejące zapalenie jamy ustnej jest rzadką chorobą błony śluzowej jamy ustnej, która najczęściej dotyczy kobiet między 30. a 60. rokiem życia [38]. Etiopatogeneza CUS nie została w pełni poznana.…”

“…Najbardziej prawdopodobne wydaje się tło autoimmunologiczne. W surowicy chorych wykrywa się przeciwciała klasy IgG SESANA (squamous epitheliumspecific antinuclear antibodies), często w bardzo wysokich mianach [38][39][40][41]. Są to przeciwciała skierowane przeciwko antygenom jądrowym komórek warstwy podstawnej nabłonka wielowarstwowego płaskiego.…”