Chronic urticaria and autoimmunity: Associations found in a large population study

Serum induced CD63 and CD203c activation tests in chronic urticaria

“…Recent a study by Confino-Cohen et al found strong association between CU and major autoimmune diseases [19]. We found quite frequent (25%) occurrence of elevated TPO in our CU patients.…”

Histamine release positive test associates with disease remission in chronic spontaneous urticaria: a proof-of-concept study

“…No statistical association of autoimmune thyroid dysfunction (or isolated thyroid autoimmunity) with HR or APST/ASST results was observed in our cohort. The mutual relationship of these two conditions is well known and accounts for 10 to 27% of cases in literature (17,18,19). In our cohort the percentage of thyroid disease is slightly greater, perhaps as a consequence of a selection bias of those patients with an antihistamine resistant CSU.…”

Introductory Chapter: Urticaria

“…Therefore, the presence of any accompanying systemic symptoms is significant. Autoimmune and rheumatologic diseases constitute the majority of this group [12]. Systemic diseases include cutaneous vasculitis, systemic lupus erythematosus, celiac disease, diabetes mellitus, Sjögren's syndrome, rheumatoid arthritis, autoimmune thyroid disease, and mastocytosis [1,12].…”

“…Autoimmune and rheumatologic diseases constitute the majority of this group [12]. Systemic diseases include cutaneous vasculitis, systemic lupus erythematosus, celiac disease, diabetes mellitus, Sjögren's syndrome, rheumatoid arthritis, autoimmune thyroid disease, and mastocytosis [1,12]. Malignancies may also trigger urticaria and the disease tends to be persistent in this case [13].…”

“…In chronic cases, initial laboratory examinations may include complete blood count, fasting blood glucose, erythrocyte sedimentation rate, C-reactive protein, kidney and liver function tests, urinalysis, and total serum Immunoglobulin-E levels. Additional tests such as antinuclear antibody, rheumatoid factor, complement C 3 and C 4 levels, thyroid hormones and autoantibodies, serology of Hepatitis viruses, Helicobacter pylori antigen, and fecal parasite examination can be performed if an infectious disease or an autoimmune disease is suspected [1,12].…”