Chronic urticaria: novel clinical and serological aspects

Asero, Riccardo; Tedeschi, A.; Lorini, M.; Salimbeni, Rossana; Zanoletti, T.; Miadonna, A.

doi:10.1046/j.1365-2222.2001.01131.x

Cited by 112 publications

(106 citation statements)

References 26 publications

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“…We cannot exclude a possible relationship with C5a or other cell-activating chemokines. However, the possibility that this factor corresponds to C5a in all cases seems questionable, as the complement fraction is formed following complement activation by anti-FcεRI autoantibodies (12), whose presence is generally associated with a clearly positive ASST result (6).…”

Section: Resultsmentioning

confidence: 99%

“…All patients underwent the ASST as previously described [6]. All patients and controls gave their informed consent to blood collection for research purposes, and the study was conducted in accordance with the Declaration of Helsinki.…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, in recent years, Eckman et al [5] demonstrated that there is no strict association between FcεRI autoantibodies and the histamine-releasing activity of serum from CSU patients. About 50% of CSU patients, a proportion that includes all those with functionally active circulating autoantibodies to FcεRI and IgE, are "autoreactive," that is, intradermal injection of autologous serum (autologous serum skin test [ASST]) elicits a wheal-and-flare reaction [6]. However, the result of the ASST does not always correlate with the result of the in vitro assay with histamine-releasing autoantibodies.…”

Section: Introductionmentioning

confidence: 99%

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Detection of Low-Molecular-Weight Mast Cell–Activating Factors in Serum From Patients With Chronic Spontaneous Urticaria

Cugno¹,

Tedeschi²,

Frossi³

et al. 2016

J Investig Allergol Clin Immunol

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Background: Functionally active autoantibodies to IgE and to the high-affinity IgE receptor (FcεRI) can be detected in serum in about 40% of patients with chronic spontaneous urticaria (CSU). Recent studies showed that serum from patients with CSU can induce activation of mast cells, irrespective of whether they carry high-affinity IgE receptors. Objective: To evaluate mast cell activation induced by factors in the serum of CSU patients with a molecular weight lower than that of autoantibodies. Methods: Eight CSU patients and 5 healthy controls were evaluated. Whole serum and serum fractionated at 100, 50, and 30 kDa were used to stimulate in vitro LAD2 mast cells. The enzymatic activity of β-hexosaminidase was evaluated in supernatants and cell pellets as a measure of mast cell degranulation. Results: Mean (SEM) release of mast cell β-hexosaminidase induced by whole serum from CSU patients was higher than that induced by serum from the healthy controls (14.4 [2.7%] vs 5.1 [2.4%]; P=.027). In addition, serum fractions below 100 kDa and below 50 kDa from CSU patients induced mast cell degranulation that was significantly higher than that induced by the corresponding fractions in sera from healthy controls (10.2% [ Conclusions: This study shows that sera from CSU patients may contain low-molecular-weight mast cell-activating factors other than autoantibodies. These factors could be an additional mechanism contributing to the pathogenesis of CSU.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Detection of Low-Molecular-Weight Mast Cell–Activating Factors in Serum From Patients With Chronic Spontaneous Urticaria

Cugno¹,

Tedeschi²,

Frossi³

et al. 2016

J Investig Allergol Clin Immunol

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“…W niektó rych krajach dostępny i możliwy do zastosowania jest test degranulacji bazofilów. Ogólne doświad czenia, w tym członków panelu, są takie, że u zdro wych osób z grupy kontrolnej i u pacjentów bez objawów PPS wynik ASST nigdy nie jest dodatni, a zatem nie stwierdza się reakcji miejscowej zdefi niowanej jako powstanie zapalnego bąbla o rumie niowym zabarwieniu [48][49][50][51][52][53][54][55][56][57][58][59][60]. W przeciwieństwie do większości wcześniej opublikowanych badań, niektóre prace wykazują relatywnie wysoki odse tek dodatniej reakcji w ASST u chorych z alergicz nymi lub niealergicznymi objawami ze strony ukła du oddechowego, wynoszący 30-50% u dorosłych pacjentów i aż do 80% w populacji dziecięcej [53][54][55][56]61].…”

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The EAACI/GA2LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update

Zuberbier¹,

Aberer²,

Asero³

et al. 2015

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“…Histaminereleasing autoantibodies that react with IgE epitopes, or are more frequently produced against the α-chain of the high affinity IgE receptor of mast cells and basophils (FcεRI), have been detected in CIU patients by the autologous serum skin test and by immunoassay (3,4). Some CIU patients may present angioedema, a reaction closely similar to urticaria that occurs in deeper tissues, which may also be observed as an isolated clinical event (1).…”

mentioning

confidence: 99%

Autoantibody production in chronic idiopathic urticaria is not associated with Helicobacter pylori infection

Atta

Rodrigues

Sousa

et al. 2004

Braz J Med Biol Res

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Chronic idiopathic urticaria (CIU) is a dermatological syndrome, characterized by raised erythematous skin lesions, that affects 20% of the general population and has been associated with autoimmunity. However, some reports have also suggested a close relationship between CIU and Helicobacter pylori infection, which is endemic in developing countries and associated with chronic gastritis, peptic ulcer disease, and gastric carcinoma. In the present study, we investigated the occurrence of autoantibodies in sera from 23 CIU subjects infected with H. pylori and from 23 CIU subjects without this infection. The presence of anti-thyroid antibodies was determined by indirect hemagglutination assay and the presence of autoantibodies to IgE and C1INH was determined by ELISA. Antibodies to thyroid antigens were detected at low titers from 100 to 400 in three of 23 (13%) CIU-infected subjects and in four of 23 (17%) CIU-noninfected subjects. The titers of anti-IgE autoantibodies were similar in these CIU groups, presenting absorbances of 1.16 ± 0.09 and 1.07 ± 0.16, respectively, while a titer of 1.14 ± 0.15 was detected in the healthy control group. The concentration of anti-C1INH autoantibodies was the same in the CIU-infected and -noninfected subjects (7.28 ± 1.31 and 7.91 ± 2.45 ng/ml, respectively), and was 7.20 ± 2.25 ng/ml in the healthy control group. However, the serum levels of complexed anti-C1INH antibodies were increased in CIU-infected subjects compared to CIU-noninfected subjects and healthy controls with an absorbance of 1.51 ± 0.21 vs 1.36 ± 0.16 and 1.26 ± 0.23, respectively (P < 0.05), indicating an impaired clearance of immune complexes in CIUinfected patients. In conclusion, no correlation was observed between H. pylori infection and autoantibody production in CIU patients consistent with reports of clinical studies.

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Chronic urticaria: novel clinical and serological aspects

Cited by 112 publications

References 26 publications

Detection of Low-Molecular-Weight Mast Cell–Activating Factors in Serum From Patients With Chronic Spontaneous Urticaria

Detection of Low-Molecular-Weight Mast Cell–Activating Factors in Serum From Patients With Chronic Spontaneous Urticaria

The EAACI/GA2LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update

Autoantibody production in chronic idiopathic urticaria is not associated with Helicobacter pylori infection

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