Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by intense polyclonal production of autoantibodies and circulating immune complexes. Some reports have associated SLE with a Th2 immune response and allergy. In the present study 21 female patients with SLE were investigated for total IgE and IgE antibodies to dust house aeroallergens by an automated enzymelinked fluorescent assay, and were also evaluated for antinuclear IgE autoantibodies by a modified indirect immunofluorescence test using HEp-2 cells as antigen substrate. Additionally, immunocapture ELISA was used to investigate serum anti-IgE IgG autoantibodies. Serum IgE above 150 IU/ml, ranging from 152 to 609 IU/ml (median = 394 IU IgE/ml), was observed in 7 of 21 SLE patients (33%), 5 of them presenting proteinuria, urinary cellular casts and augmented production of anti-dsDNA antibodies. While only 2 of 21 SLE patients (9.5%) were positive for IgE antibodies to aeroallergens, all 10 patients with respiratory allergy (100%) from the atopic control group (3 males and 7 females), had these immunoglobulins. SLE patients and healthy controls presented similar anti-IgE IgG autoantibody titers (X = 0.37 ± 0.20 and 0.34 ± 0.18, respectively), differing from atopic controls (0.94 ± 0.26). Antinuclear IgE autoantibodies were detected in 17 of 21 (81%) sera from SLE patients, predominating the fine speckled pattern of fluorescence, that was also observed in IgG-ANA. Concluding, SLE patients can present increased IgE levels and antinuclear IgE autoantibodies without specific clinical signs of allergy or production of antiallergen IgE antibodies, excluding a possible association between SLE and allergy.

Chronic idiopathic urticaria (CIU) is a dermatological syndrome, characterized by raised erythematous skin lesions, that affects 20% of the general population and has been associated with autoimmunity. However, some reports have also suggested a close relationship between CIU and Helicobacter pylori infection, which is endemic in developing countries and associated with chronic gastritis, peptic ulcer disease, and gastric carcinoma. In the present study, we investigated the occurrence of autoantibodies in sera from 23 CIU subjects infected with H. pylori and from 23 CIU subjects without this infection. The presence of anti-thyroid antibodies was determined by indirect hemagglutination assay and the presence of autoantibodies to IgE and C1INH was determined by ELISA. Antibodies to thyroid antigens were detected at low titers from 100 to 400 in three of 23 (13%) CIU-infected subjects and in four of 23 (17%) CIU-noninfected subjects. The titers of anti-IgE autoantibodies were similar in these CIU groups, presenting absorbances of 1.16 ± 0.09 and 1.07 ± 0.16, respectively, while a titer of 1.14 ± 0.15 was detected in the healthy control group. The concentration of anti-C1INH autoantibodies was the same in the CIU-infected and -noninfected subjects (7.28 ± 1.31 and 7.91 ± 2.45 ng/ml, respectively), and was 7.20 ± 2.25 ng/ml in the healthy control group. However, the serum levels of complexed anti-C1INH antibodies were increased in CIU-infected subjects compared to CIU-noninfected subjects and healthy controls with an absorbance of 1.51 ± 0.21 vs 1.36 ± 0.16 and 1.26 ± 0.23, respectively (P < 0.05), indicating an impaired clearance of immune complexes in CIUinfected patients. In conclusion, no correlation was observed between H. pylori infection and autoantibody production in CIU patients consistent with reports of clinical studies.

Este artigo, através de revisão bibliográfica e análise documental, objetiva discorrer sobre os princípios constitucionais da administração pública e da gestão democrática do ensino público no contexto da gestão da Política de Assistência Estudantil, no âmbito do Curso Técnico de Nível Médio Integrado em Agropecuária, do IF Baiano, Campus Senhor do Bonfim, no ano de 2019, a partir da análise da Resolução n.º 01, de 29 de janeiro de 2019, que instituiu a Política de Assistência Estudantil do IF Baiano. Nesta pesquisa, evidenciou-se que o modelo de gestão escolar participativa se mostra adequado para o ambiente escolar, à medida que permite a aplicação do princípio constitucional da gestão democrática do ensino público e a observância dos princípios constitucionais expressos da Administração Pública, a saber: legalidade, impessoalidade, moralidade, publicidade e eficiência. No ensino médio integrado, tal modelo visa a democratização do acesso, permanência e êxito no estudante, as quais se constituem em demandas possíveis de serem contempladas mediante programas de auxílio estudantil, à medida que estes contribuem para estimular a criatividade, a reflexão crítica, as atividades e os intercâmbios cultural, esportivo, artístico, político, científico e tecnológico dos estudantes do Instituto Federal Baiano, com vistas à sua formação integral. Ademais, constatou-se a necessidade de aprofundamento da pesquisa, através de estudo de caso de abordagem quali-quantitativa, a fim de identificar os fatores que necessitam ser superados para implemento da gestão da Política de Assistência Estudantil do IF Baiano.