Immunoglobulin E and systemic lupus erythematosus

Atta, Ajax Mercês; Sousa, Cláudia Pereira de; Carvalho, Edgar M.; Sousa-Atta, M.L.B.

doi:10.1590/s0100-879x2004001000008

Cited by 41 publications

(31 citation statements)

References 13 publications

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“…This hypothesis could explain the development of certain autoimmune disease such as the chronic urticaria. However, in other autoimmune diseases (such as SLE) where increased IgE levels have been described, these were not associated with atopic features or increased allergic disease in this population [23]. Thus, high levels of circulating IgE may simply reflect the presence of a Th2 response in a nonallergic setting.…”

Section: Basophils and Autoimmune Diseasesmentioning

confidence: 61%

“…Thus, we set out to determine if SLE patients had circulating autoreactive antibodies (anti-dsDNA IgE or anti-IgE IgGs) that might be able to stimulate basophils. As previously mentioned, these autoreactive antibodies were already described to be present in SLE and urticaria's [23,50]. However, it was unclear as to whether all SLE patients generated such antibodies.…”

Section: Basophils and The Th2 Environment In Hu-man Slementioning

confidence: 91%

“…In these aforementioned diseases, a Th2 component is well described and the basophil through its immunomodulatory and effector responses contributes to the development of the autoimmune symptoms. While IgE is clearly recognized as a "Th2 marker" in human pathologies there have been multiple reports [23,55,56] where autoimmune patients are described to have increased levels of IgE but are studied in the context of their Th1 and Th17 responses [57]. While the importance of Th1-and Th17-driven responses in the development of autoimmunity is evident, it also seems unlikely that the presence of a Th2 response would not be contributory to the disease.…”

Section: Basophils and Autoimmune Diseasesmentioning

confidence: 99%

“…Thus, these findings suggest the direct involvement of autoreactive IgE in human lupus nephritis. Since previous studies [23,55] had demonstrated that SLE patients had increased circulating IgE, we explored if total IgE was increased in our cohort of patients. While not all patients had increased levels of IgE (whereas all had anti-dsDNA IgE), in patients where total IgE was increased, an association with disease activity and active lupus nephritis was noted.…”

Section: Basophils and The Th2 Environment In Hu-man Slementioning

confidence: 99%

“…Thus, this presented an opportunity to explore whether the Th2 phenotype can contribute to the development of a lupus-like disease. While Th2 responses have been described in SLE patients [23], the presence and the role of these responses is unexplored and the concept of Th2 contribution to SLE is controversial, given that Th1, Th17, and loss of regulatory T cell function have been involved [24][25][26][27][28][29][30].…”

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confidence: 99%

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Basophils and IgE: Linking the Allergic Environment to Autoimmunity

Karasuyama¹

2010

TOALLJ

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Abstract:As outlined in some of the accompanying articles in this issue, the role of the basophil as an effector cell in allergy and in host defense (particularly to parasites) has long been recognized. However, recent advances advocate for the basophil as an immunomodulatory cell that can promote naïve CD4 + T cell commitment to Th2 cell differentiation. While this is in keeping with the concept that the basophil is important in an allergic environment, new discoveries suggest that basophils may be immunomodulatory beyond the context of allergic disease. Here we mainly discuss our own work, which provides a new paradigm for the role of basophils beyond allergy. Our findings demonstrate the importance of autoreactive IgE's, IL-4 and basophils in promoting autoantibody production and the development of lupus nephritis. The conclusions drawn are based on studies in a mouse model (Lyn -/-mice) of spontaneous systemic lupus erythematosus (SLE)-like disease as well as from analysis of the relationship between disease activity in SLE patients and their levels of autoreactive IgE's and activated basophils with antigen presenting capability. The findings demonstrate a link between the Th2 environment and autoimmunity and provide new areas of investigation with therapeutic potential.

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Section: Basophils and Autoimmune Diseasesmentioning

confidence: 61%

Section: Basophils and The Th2 Environment In Hu-man Slementioning

confidence: 91%

Section: Basophils and Autoimmune Diseasesmentioning

confidence: 99%

Section: Basophils and The Th2 Environment In Hu-man Slementioning

confidence: 99%

mentioning

confidence: 99%

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Basophils and IgE: Linking the Allergic Environment to Autoimmunity

Karasuyama¹

2010

TOALLJ

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Anti-dsDNA antibodies in Brazilian patients of mainly African descent with systemic lupus erythematosus: lack of association with lupus nephritis

et al. 2009

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Renal disease is associated with morbidity and mortality in systemic lupus erythematosus (SLE) and anti-dsDNA antibodies with SLE immunopathogenesis. We investigated the dsDNA antibody profile of 84 Brazilian SLE patients, 27 with lupus nephritis. Thirty-six (39.1%) patients had dsDNA IgG antibodies shown in enzyme-linked immunosorbent assay (454.7 +/- 281.1 WHO units/mL), nine presenting renal disease. The following profile of dsDNA antibodies was demonstrated in Crithidia luciliae test: IgA (seven out of 36; 19.4%), IgG (22 out of 36, 66.1%); IgM (nine out of 36, 25.0%), and IgE (four out of 36, 11.1%). Two or three isotypes of dsDNA antibodies were observed in nine (25.0%) patients, while 11 (30.5%) were seronegative in the C. luciliae test. Patients with dsDNA antibodies had lower serum C3 and C4 when compared with SLE individuals without these immunoglobulins (P < 0.01 and P < 0.001, respectively). There was no association between any dsDNA antibody isotype and lupus kidney disease nor was anti-dsDNA IgM antibody associated with absence of nephritis.

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Basophils and Autoreactive IgE in the Pathogenesis of Systemic Lupus Erythematosus

Charles

Rivera

2011

Curr Allergy Asthma Rep

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Systemic lupus erythematosus (SLE) is a heterogeneous disease that can affect multiple organs. A hallmark of this disease, like for other autoimmune diseases, is the presence of large amounts of autoantibodies. As such SLE is considered to be a B cell disease perpetuated by the expansion of autoreactive T and B cells. The T cells involved have long been considered to be Th1 and Th17 cells as these potent pro-inflammatory cells can be found in the tissues of SLE patients. Recent advances point to a role for the Th2 environment in contributing to SLE through promotion of autoantibody production. Here we describe the recent work focusing on autoreactive IgE and the activation of basophils as promoting the production of autoantibodies in SLE. The findings, both in a mouse model of SLE and in human SLE subjects, support the concept that the activation of the basophil by autoreactive IgE-containing immune complexes serves to amplify the production of autoantibodies and contributes to the pathogenesis of disease. We propose that therapeutic targeting of this amplification loop by reducing the levels of circulating autoreactive IgE may have benefit in SLE.

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Immunoglobulin E and systemic lupus erythematosus

Cited by 41 publications

References 13 publications

Basophils and IgE: Linking the Allergic Environment to Autoimmunity

Basophils and IgE: Linking the Allergic Environment to Autoimmunity

Anti-dsDNA antibodies in Brazilian patients of mainly African descent with systemic lupus erythematosus: lack of association with lupus nephritis

Basophils and Autoreactive IgE in the Pathogenesis of Systemic Lupus Erythematosus

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