Chronic Venous Insufficiency and Dystrophic Subcutaneous Calcification

Abstract

165 IMAGENS MÉDICASantibodies and the serum cryoglobulins was normal. No evidence of neoplasm was found. CVI was confirmed on Doppler ultrasonography and the histological examination of the ulcer showed dysmorphic calcification. CVI promotes the deposition of calcium phosphate in the tissues. 1,2 Calcium deposits cause persistent inflammatory reaction and lead to leg ulcer recurrences which increase the risk of further calcium salt deposition. 3,4 Our patient underwent analgesic treatment and started hyperbaric oxygen therapy with clinical improvement.A 76-year old women was referred to the internal medicine department for subcutaneous calcifications on her legs (Fig. 1). She had a history of chronic venous insufficiency (CVI) of the lower extremities with chronic ulcerative lesions. The physical examination showed induration of the legs and subcutaneous white calcifications (Fig. 2). The patient had no other associated illnesses and had normal levels of parathyroid hormone, calcium, phosphorus, serum creatinine and 25-hydroxycholecalciferol. The immunological study for scleroderma, antiphospholipid

Dystrophic Calcification of the Lower Leg in a Patient with Chronic Lower Extremity Venous Insufficiency and Diabetes Mellitus: A Case Report and Literature Review

“…In addition, cell necrosis could cause a lack of certain calcification inhibitors; creating a more acidic environment also leads to calcification. Moreover, CVI can promote the deposition of calcium salts, trigger a continuous inflammatory response, and cause further aggravation of ulcers, so the incidence of malnutrition calcification caused by CVI seems to be related to the course of the disease and clinical severity 6 …”

“…Moreover, CVI can promote the deposition of calcium salts, trigger a continuous inflammatory response, and cause further aggravation of ulcers, so the incidence of malnutrition calcification caused by CVI seems to be related to the course of the disease and clinical severity. 6 Generally, two calcification patterns can be observed in X-ray examinations: punctate and trabecular/reticulate types. Calcification may start from punctate and then progress to the trabecular/reticulate type because the trabecular/reticulate type is mainly seen in patients with a long course of disease and/or high clinical severity.…”

Calcinose distrófica cutânea na doença venosa crônica de membros inferiores

“…Nesse contexto, existem propostas de tratamento, envolvendo desde medidas conservadoras, com curativos regulares, remoção do material com extração mecânica ( Figura 5 ) ou com auxílio de medicamentos, remoção cirúrgica ou até opções ablativas, como laser de CO 2 . No entanto, todas carecem de comprovação 14 - 18 .…”