Chronic Venous Insufficiency Disease

Shami, S.K.; Sarin, S.; Scurr, J.H.

doi:10.1007/s005479900007

Cited by 3 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CVD is generally diagnosed on the basis of medical history, clinical examination and duplex color ultrasound. 1 The main symptoms of CVD are feeling of swelling, heaviness and tightness in the legs, or pain in the lower limbs, and they increase in standing position and in summer. 2 The symptoms are persistent and the disease is progressive, resulting in physical, social and psychological suffering with significant negative impact on quality of life.…”

Section: Introductionmentioning

confidence: 99%

“… 2 The symptoms are persistent and the disease is progressive, resulting in physical, social and psychological suffering with significant negative impact on quality of life. 1 , 2 …”

Section: Introductionmentioning

confidence: 99%

“…Venous ulcers, the ultimate stage of CVD, are present in 1–2% of the Northwestern population and are a heavy burden, both for patients and public health systems. 1 …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Is There a Difference in the Clinical Efficacy of Diosmin and Micronized Purified Flavonoid Fraction for the Treatment of Chronic Venous Disorders? Review of Available Evidence

Cazaubon

Benigni

Steinbruch³

et al. 2021

VHRM

View full text Add to dashboard Cite

Flavonoids are oral venoactive drugs frequently prescribed to relieve the symptoms of chronic venous disorders (CVD). Among venoactive drugs, diosmin is a naturally occurring flavonoid glycoside that can be isolated from various plant sources; it can also be obtained after conversion of hesperidin extracted from citrus rinds. Micronized purified flavonoid fraction (MPFF) is a preparation that contains mainly diosmin and a small fraction of hesperidin. We performed a state-of-the-art literature review to collect and analyze well-conducted randomized clinical studies comparing diosmin – also called non-micronized or hemisynthetic diosmin – 600 mg a day and MPFF, 1000 mg a day. Three clinical studies met the criteria and were included for this literature review. These clinical studies showed a significant decrease of CVD symptom intensity (up to approximately 50%) and global patient satisfaction after one-to-six-month treatment with diosmin or MPFF, without statistical differences between these two forms of diosmin. Both treatments were well tolerated with few mild adverse drug reactions reported. Overall, based on this literature review, there is no clinical benefit to increase the dose of diosmin beyond 600 mg per day, to use the micronized form, or to add hesperidin, since clinical efficacy on venous symptomatology is achieved with 600 mg per day of pure non-micronized diosmin. This challenges the status of diosmin – 600 mg a day – in guidelines for the management of CVD, which is currently categorized 2C (weak recommendations for use and poor quality of evidence), while the most widely used and assessed preparation MPFF is rated 1B (strong recommendation for use and moderate quality of evidence).

show abstract

Section: Introductionmentioning

confidence: 99%

“… 2 The symptoms are persistent and the disease is progressive, resulting in physical, social and psychological suffering with significant negative impact on quality of life. 1 , 2 …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Is There a Difference in the Clinical Efficacy of Diosmin and Micronized Purified Flavonoid Fraction for the Treatment of Chronic Venous Disorders? Review of Available Evidence

Cazaubon

Benigni

Steinbruch³

et al. 2021

VHRM

View full text Add to dashboard Cite

show abstract

“…VI can lead to venous hypertension, oedema, lipodermatosclerosis and inflammatory changes and, eventually, a venous leg ulcer. 1,3…”

Section: Introductionmentioning

confidence: 99%

An investigation of skin perfusion in venous leg ulcer after exercise

2017

View full text Add to dashboard Cite

show abstract

“…It has long been accepted that valvular incompetence in superficial veins and post-thrombotic occlusion or incompetence of deep veins are the main factors in the genesis of venous ulcers. 1,2 While the presence of isolated incompetence in communicating (perforating) veins is questionable, 1 the role of perforating vein incompetence in superficial or deep venous stasis has been demonstrated. 3,4 The precise mechanism for the pathogenesis of venous ulcer formation remains unclear, and various theories have been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%