Chronicity and severity of maternal postpartum depression and infant sleep disorders: A population-based cohort study in southern Brazil

Pinheiro, Karen Amaral Tavares; Pinheiro, Ricardo Tavares; Silva, Ricardo Azevedo da; Coelho, Fábio Monteiro da Cunha; Quevedo, Luciana de Ávila; Godoy, Russélia Vanila; Jansen, Karen; Horta, Bernardo Lessa; Oses, Jean Pierre

doi:10.1016/j.infbeh.2010.12.006

Cited by 27 publications

(21 citation statements)

References 17 publications

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“…Similar to the findings of previous studies [4], the mothers in our sample with PPAD or anxiety disorder tended to have offspring with low motor development. In the original experiments by Denenberg and colleagues, it was clearly shown that the mother-infant relationship had decisive effects on infant development.…”

Section: Discussionsupporting

confidence: 89%

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Serum NGF, BDNF and IL-6 Levels in Postpartum Mothers As Predictors of Infant Development: The Influence of Affective Disorders

Pinheiro

Coelho

et al. 2014

PLoS ONE

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BackgroundEarly adverse experiences are associated with increased risk of developing psychiatric disorders, although little is known about the neurobiological mediators involved. The mechanisms by which early environmental influences may mediate vulnerability in the development of offspring await further investigation. The present study correlated the NGF, BDNF, IL-6 and cortisol levels of mothers with postpartum affective disorders (PPAD) with infant development.MethodsA longitudinal study was performed with 152 pregnant women and their infants. Between 60 and 120 days after delivery, women were interviewed and provided biological samples for biochemical analysis, and the infants were examined for neurobiological-motor development.ResultsOverall, the mothers' history of affective disorders, PPAD and anxiety disorder were associated with infant motor development. Using an adjusted linear regression analysis, PPAD (p = 0.049), maternal anxiety disorder (p = 0.043), NGF level (p = 0.034) and infant cortisol level (p = 0.013) were associated with infant motor development. Using a factorial analysis of primary components, two components were retained. The psychological factor was characterized by a positive loading of a history of affective disorder, PPAD and anxiety disorder. For the biological factor, infant cortisol adhered negatively with infant motor development, but NGF was positively associated. The psychological factor had a negative association, but the biological factor had a positive association with infant motor development.ConclusionsThere are few studies that have focused on the relationship of biomarkers and infant neurodevelopment. Our study points that psychological and biological factors are associated with infant motor development, however the causal relationship between these factors is still to be defined.

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Section: Discussionsupporting

confidence: 89%

“…Maternal deprivation may occur due to postpartum affective disorders (PPAD) [3]. Mothers with affective disorder spend less time positively interacting with their children and show more inconsistent and ineffective child management strategies than non-depressed parents [4].…”

Section: Introductionmentioning

confidence: 99%

Serum NGF, BDNF and IL-6 Levels in Postpartum Mothers As Predictors of Infant Development: The Influence of Affective Disorders

Pinheiro

Coelho

et al. 2014

PLoS ONE

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“…100 Another study from Pelotas, Brazil found that postpartum depression at 2 months was associated with sleep disturbances of infants at 12 months of age. 101 Using a community based cross-sectional survey conducted at 3-24 months, Hadley et al in Ethiopia found that children with mothers who had higher symptoms of depression and anxiety (assessed using Hopkins Symptoms checklist) were statistically significantly more likely to score low in all measures of development even after adjusting for nutritional stunting. 102 Maternal postpartum depression was noted to be associated with 6-fold increased odds of being delayed for emotional development (OR=5.9; 95% CI: 3.0-11.9), language development (OR=5.4; 95% CI: 2.3-12.4) and delayed gross motor development (OR=2.8; 95% CI: 1.2-6.6) in Pakistan.…”

Section: Resultsmentioning

confidence: 99%

Epidemiology of maternal depression, risk factors, and child outcomes in low-income and middle-income countries

Gelaye

Rondón

Araya

et al. 2016

The Lancet Psychiatry

836

711

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Maternal depression, a non-psychotic depressive episode of mild to major severity, is one of the major contributors of pregnancy-related morbidity and mortality. Maternal depression (antepartum or post partum) has been linked to negative health-related behaviours and adverse outcomes, including psychological and developmental disturbances in infants, children, and adolescents. Despite its enormous burden, maternal depression in low-income and middle-income countries remains under-recognised and undertreated. In this Series paper, we systematically review studies that focus on the epidemiology of perinatal depression (ie, during antepartum and post-partum periods) among women residing in low-income and middle-income countries. We also summarise evidence for the association of perinatal depression with infant and childhood outcomes. This review is intended to summarise fi ndings from the existing literature, identify important knowledge gaps, and set the research agenda for creating new generalisable knowledge pertinent to increasing our understanding of the prevalence, determinants, and infant and childhood health outcomes associated with perinatal depression. This review is also intended to set the stage for subsequent work aimed at reinforcing and accelerating investments toward providing services to manage maternal depression in low-income and middle-income countries.

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“…Furthermore, maternal depression both during pregnancy and after delivery may affect the infant's cognitive and emotional development [17], [18], and these effects may persist through the childhood and teenage years [19], [20]. Prenatal depression is associated with sleep disturbances in the newborn (less deep sleep and more disorganized sleep) [21], and both prenatal and postnatal depression is associated with infant sleep problems one year after delivery [18], [22]. Poor maternal sleep has been linked to perceived sadness of the infant (perceived by the mother) [23].…”

Section: Introductionmentioning

confidence: 99%

Can Insomnia in Pregnancy Predict Postpartum Depression? A Longitudinal, Population-Based Study

2014

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BackgroundInsomnia and depression are strongly interrelated. This study aimed to describe changes in sleep across childbirth, and to evaluate whether insomnia in pregnancy is a predictor of postpartum depression.MethodsA longitudinal, population-based study was conducted among perinatal women giving birth at Akershus University Hospital, Norway. Women received questionnaires in weeks 17 and 32 of pregnancy and eight weeks postpartum. This paper presents data from 2,088 of 4,662 women with complete data for insomnia and depression in week 32 of pregnancy and eight weeks postpartum. Sleep times, wake-up times and average sleep durations were self-reported. The Bergen Insomnia Scale (BIS) was used to measure insomnia. The Edinburgh Postnatal Depression Scale (EPDS) was used to measure depressive symptoms.ResultsAfter delivery, sleep duration was reduced by 49 minutes (to 6.5 hours), and mean sleep efficiency was reduced from 84% to 75%. However, self-reported insomnia scores (BIS) improved from 17.2 to 15.4, and the reported prevalence of insomnia decreased from 61.6% to 53.8%. High EPDS scores and anxiety in pregnancy, fear of delivery, previous depression, primiparity, and higher educational level were risk factors for both postpartum insomnia and depression. Insomnia did not predict postpartum depression in women with no prior history of depression, whereas women who recovered from depression had residual insomnia.LimitationsDepression and insomnia were not verified by clinical interviews. Women with depressive symptoms were less likely to remain in the study.ConclusionsAlthough women slept fewer hours at night after delivery compared to during late pregnancy, and reported more nights with nighttime awakenings, their self-reported insomnia scores improved, and the prevalence of insomnia according to the DSM-IV criteria decreased. Insomnia in pregnancy may be a marker for postpartum recurrence of depression among women with previous depression.

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Chronicity and severity of maternal postpartum depression and infant sleep disorders: A population-based cohort study in southern Brazil

Cited by 27 publications

References 17 publications

Serum NGF, BDNF and IL-6 Levels in Postpartum Mothers As Predictors of Infant Development: The Influence of Affective Disorders

Serum NGF, BDNF and IL-6 Levels in Postpartum Mothers As Predictors of Infant Development: The Influence of Affective Disorders

Epidemiology of maternal depression, risk factors, and child outcomes in low-income and middle-income countries

Can Insomnia in Pregnancy Predict Postpartum Depression? A Longitudinal, Population-Based Study

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