Chronisch entzündliche Darmerkrankungen bei Kindern und Jugendlichen

Meier, Christel; Thönneßen, C.; Rothe, Ulrike; Henker, J; Quietzsch, J; Prager, J; Bürk, Guido; Kieß, Wieland; Richter, Thomas; Jugendlichen, Mitglieder des Sächsischen Registers für Ced bei Kindern und

doi:10.1007/s00112-005-1226-y

Cited by 5 publications

(2 citation statements)

References 18 publications

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“…Characteristics of these diseases are recurrent or persistent inflammatory activity with concomitant increased nutrient loss with increased nutrient requirements. 1 Consequences can be expressed in deficiency symptoms, growth and development retardation and in psychological form. 2 Due to their chronic relapsing course, these diseases have an influence on the physical, psychosocial and professional development of children and adolescents.…”

Section: Introductionmentioning

confidence: 99%

Study protocol epidemiology of inflammatory bowel disease in childhood and adolescence: a systematic review

et al. 2020

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IntroductionThe incidence and prevalence of chronic inflammatory bowel diseases in childhood and adolescence is increasing and varies internationally. The systematic literature review aims to describe international epidemiological trends of chronic inflammatory bowel diseases in the child and adolescence age. A period from 1970 to 2019 will be taken into account when searching for suitable studies as well as geographical differences in the development of incidences will be presented.Methods and analysisThe literature databases PubMed and Embase will be searched for the period from 01 January 1970 to 31 December 2019 using linked keywords. A manual search in bibliographies of already published and relevant systematic reviews will complete the systematic literature search. The included studies will be combined in a qualitative and quantitative synthesis and statistically evaluated.Ethics and disseminationEthical approval is not required for this study as it is a systematicreview. The results will be submitted to peer-reviewed journals and presented in national andinternational meetings. This research received no specific grant from any funding agency inthe public, commercial or not-for-profit sectors. This systematic review protocol was registeredwith the International Prospective Register of Systematic Reviews (PROSPERO-NR:CRD42020168644).

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Section: Introductionmentioning

confidence: 99%

Study protocol epidemiology of inflammatory bowel disease in childhood and adolescence: a systematic review

et al. 2020

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“…Characteristic features of these diseases include recurrent or persistent inflammatory activity accompanied by increased nutrient malabsorption and elevated nutritional requirements [ 7 ]. In children and adolescents, the consequences of these diseases can manifest as nutritional deficiencies, growth and developmental retardation, as well as psychosocial stressors.…”

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IBD: Who Knows Best?

Weidner

2023

Dig Dis Sci

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Predictors of improvement in disease activity in childhood and adolescent Crohn’s disease: an analysis of age, localization, initial severity and drug therapy — data from the Saxon Registry for Inflammatory Bowel Disease in Children in Germany (2000–2014)

Weidner,

Zoch,

Kern

et al. 2024

Eur J Pediatr

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The escalating worldwide prevalence of Crohn’s disease (CD) among children and adolescents, coupled with a trend toward earlier onset, presents significant challenges for healthcare systems. Moreover, the chronicity of this condition imposes substantial individual burdens. Consequently, the principal objective of CD treatment revolves around rapid inducing remission. This study scrutinizes the impact of age, gender, initial disease localization, and therapy on the duration to achieve disease activity amelioration. Data from the Saxon Pediatric IBD Registry in Germany were analyzed over a period of 15 years. In addition to descriptive methods, logistic and linear regression analyses were conducted to identify correlations. Furthermore, survival analyses and Cox regressions were utilized to identify factors influencing the time to improvement in disease activity. These effects were expressed as Hazard Ratios (HR) with 95% confidence intervals. Data on the clinical course of 338 children and adolescents with CD were available in the registry. The analyses showed a significant correlation between a young age of onset and the severity of disease activity. It was evident that treatment with anti-TNF (Infliximab) was associated with a more favorable prognosis in terms of the time required for improvement in disease activity. Similarly, favorable outcomes were observed with the combination therapies of infliximab with enteral nutrition therapy and Infliximab with immunosuppressants.Conclusion: Our analysis of data from the Saxon Pediatric IBD Registry revealed that the timeframe for improvement of disease activity in pediatric Crohn’s disease is influenced by several factors. Specifically, patient age, treatment modality, and initial site of inflammation were found to be significant factors. The study provides important findings that underline the need for individualized treatment.

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Chronisch entzündliche Darmerkrankungen bei Kindern und Jugendlichen

Cited by 5 publications

References 18 publications

Study protocol epidemiology of inflammatory bowel disease in childhood and adolescence: a systematic review

Study protocol epidemiology of inflammatory bowel disease in childhood and adolescence: a systematic review

IBD: Who Knows Best?

Predictors of improvement in disease activity in childhood and adolescent Crohn’s disease: an analysis of age, localization, initial severity and drug therapy — data from the Saxon Registry for Inflammatory Bowel Disease in Children in Germany (2000–2014)

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