Chronische Trichinose und neuromuskul�re Erkrankungen

Gullotta, F.; Fröscher, W.

doi:10.1007/bf00344062

Cited by 3 publications

(3 citation statements)

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“…The option of anthelmintics include albendazole, mebendazole and or pyrantel. Rayia et al [23] proposed Bevacizumab as a new option on therapy of muscle phase of Trichinella spiralis infection [28].…”

Section: Life Cycle and Pathogenesismentioning

confidence: 99%

Predilection Site for the Meat Lover Trichinella spp Larvae and its Pathogenesis and Potency in Human Host

Siagian

2024

Asian J. Res. Zool.

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Aims: To revisited carefully previously published articles available in the internet regarding predilection site of Trichinella spp larvae including their pathogenesis and its potency. Discussion: By carefully reviewing previously published literature available in the internet regarding the parasite Trichinella tropism to its host’s striated muscle, the author briefly withdraw some important keypoint to be revealed. The nematode Trichinella spp causes serious zoonosis called trichinellosis, a disease affecting striated or skeletal muscles which consider as one of tropical disease. Even though its natural host varied, but infection among live stocks, such as pigs and other animals, which are raising public health concern. Human infection occurs after consumption of raw or undercooked meat or meat products contain muscle larvae of T. spiralis. The tropism of the parasite for individual striated muscles and/or striated muscle groups varies significantly. Trichinella spp. has a direct life cycle where all three life cycle stages (the infective muscle larvae, adult, and new born larvae) happen serially in one host only. Intestine-dwelling adults of Trichinella produce newborn larvae that bypass the enterocyte, enter the bloodstream and colonize skeletal muscle. The muscle larvae assemble excretory-secretory products which play crucial role in establishing and maintaining persistent parasitism and the host’s immune modulation and evasion. It turns out that excretory-secretory products from muscle larvae and mature worm also have hidden medical potential that can be used to treat allergic problems, inflammation-based diseases, autoimmunity and even malignancy. Conclusion: Trichinellosis is a serious and potentially fatal zoonosis which transmitted through consuming raw or uncooked contaminated meat or its comestibles. Its primary tropism is to the host’s striated muscle and infection can persist for a long time facilitated by several reciprocities of its product (e.g., excretory-secretory) with the host’s cell and immune system. Fortunately, there are several promising potency in the field of therapeutic and prevention medicine which should be explored intensely.

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Section: Life Cycle and Pathogenesismentioning

confidence: 99%

Predilection Site for the Meat Lover Trichinella spp Larvae and its Pathogenesis and Potency in Human Host

Siagian

2024

Asian J. Res. Zool.

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“…Wichtigste Nachweisrnethode bei serologisch negativen Personen ist die Muskelbiopsie, insbesondere nach Abklingen der klinischen Symptomatik (24,26,47,67). Vitale Tnichinen und eine periparasitäre Entzundung können noch Jahrzehnte nach der Infektion nachweisbar sein (24). Im vitalen Quetschpraparat bzw.…”

Section: Muskelbiopsieunclassified

“…>rheumatoid<< geschilderten Schmerzen, die nach Belastung der betroffenen Muskeigruppen oft zunehmen, können bei einzelnen Patienten Jahrzehnte chronisch oder chronisch rezidivierend auftreten. Als morphologische Basis der chronischen Muskelschmerzen ist die periparasitäre Herdmyositis anzusehen(19,24,26), die sowohl in der Nachbarschaft vitaler als auch abgestorbener Trichinen gefunden werden kann. Neben Muskelschmerzen werden im chronischen Stadium eine Schwäche einzelner Muskeigruppen oder eine ailgemeine Muskelschwäche, eine vorschnelle F.rmüdbarkeit, Gelenkbeschwerden, Schmerzen oder Brennen im Augenbereich, Kopfschmerzen, eine aligemeine vegetative Labiliät, Nausea, Schwindel, vermehrte Reizbarkeit, Fieberschübe, Beinödeme, Herzbeschwerden und eine reaktive Depression angegeben(18,19,21,30,40,47,48,68).…”

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Trichinose des Nervensystems

Fröscher¹,

Saathoff²

1986

Akt Neurol

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Canine trichinosis with signs of neuromuscular disease

Lindberg

Bornstein

Landerholm³

et al. 1991

J of Small Animal Practice

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A six‐year‐old fox terrier bitch, used for badger hunting, developed acutely progressive painless disturbance of locomotion with pronounced weakness. Evidence of central nervous disease or myasthenia gravis was not present. Muscle histology revealed trichinella larvae and changes consistent with a combined inflammatory myopathy and neuropathy. An enzyme‐linked immunosorbent assay (ELISA) showed significantly increased serum levels of antibodies to Trichinella spiralis antigen. It is likely that the signs of neuromuscular disease shown by the dog were due to the trichinella infection. The case illustrates that symptomatic trichinosis should be considered in the clinical workup of myopathies in dogs with access to potentially trichinella‐infected wildlife.

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Chronische Trichinose und neuromuskul�re Erkrankungen

Cited by 3 publications

References 5 publications

Predilection Site for the Meat Lover Trichinella spp Larvae and its Pathogenesis and Potency in Human Host

Predilection Site for the Meat Lover Trichinella spp Larvae and its Pathogenesis and Potency in Human Host

Trichinose des Nervensystems

Canine trichinosis with signs of neuromuscular disease

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