Chronischer idiopathischer Husten

Kardos, Péter

doi:10.1055/s-0042-121765

Cited by 4 publications

(8 citation statements)

References 15 publications

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“…Accordingly, the cough receptors' increased sensitivity and the changed central cough modulations lead to hyperreactivity of the cough reflex [33,34]. In postmenopausal women, the chronic cough stimulus is also due to the cough receptors' increased sensitivity and/or a changed central cough modulation [12][13][14][15][16]. However, according to the definition, no CIC can be assigned to the patients in this study, as they did not go through the necessary diagnostics.…”

Section: Discussionmentioning

confidence: 98%

“…Then it is defined as chronic cough of unclear etiology or a chronic idiopathic cough (CIC). The clinical complaints of CIC, sometimes persisting for years, are a dry and excruciating cough, the urge to clear the throat and a globe feeling [1,2]. According to recent literature, idiopathic cough occurs in up to 20-42% of cases of chronic cough and can be triggered by weak subclinical triggers such as gastric acid, thermal stimuli, or passive smoking [41].…”

Section: Discussionmentioning

confidence: 99%

“…Chronic cough in adults is defined by its persistence for at least 8 weeks [1][2][3][4]. Chronic cough is associated with a significant impairment of physical performance and quality of life [5][6][7][8][9][10][11].…”

Section: Purposementioning

confidence: 99%

“…Middle-aged women who complain of chronic cough are suspected to have a causal relationship between coughing irritation and post-menopausal changes [12][13][14][15][16].…”

Section: Purposementioning

confidence: 99%

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Chronic cough in postmenopausal women and its associations to climacteric symptoms

Ziller

Oppermann

Cassel

et al. 2021

Preprint

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BackgroundPostmenopausal women often have chronic cough, which is likely caused by hormonal changes affecting lung function and the mucous membrane of the airways, causing hypersensitivity of the cough reflex. Therefore, postmenopausal hormonal changes could play a key role in the association between increased cough and menopause. The aim of this study is to evaluate the relation of chronic cough and postmenopausal symptoms.MethodsWe performed a questionnaire-based cohort study in generally healthy postmenopausal women (age 45–65 years). Women with cough of known origin were excluded. Comorbidities, medication and baseline data were collected. The Menopause Rating Scale II (MRS II) was combined with the Leicester Cough Questionnaire (LCQ). Groups were divided in chronic cough versus non-coughing participants, chronic cough was defined as symptoms over 8 weeks. We performed correlations and logistic regression for predicting cough based on postmenopausal symptoms.ResultsSixty-six of 200 women (33%) reported mild to heavier symptoms of chronic cough over 8 weeks. No significant differences in baseline data (age, BMI, onset of menopause, years since menopause, concomitant diseases, and medication) were found between coughing and non-coughing women. The MRS II showed higher menopausal symptoms in patients with cough, with significant differences in 2 of the 3 MRS-domains (urogenital (p < 0.001) and somato-vegetative (p < 0.001)). Climacteric symptoms correlated strongly with parameters of cough (p<0.001). On the basis of the MRS total score (p<0.001) and the somato-vegetative and urogenital domains (p<0,05), the prediction for respiratory complaints could be shown.DiscussionChronic cough was significantly associated with menopausal symptoms. Therefore chronic cough as a possible climacteric symptom and its underlying mechanisms should be further explored.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Purposementioning

confidence: 99%

“…Middle-aged women who complain of chronic cough are suspected to have a causal relationship between coughing irritation and post-menopausal changes [12][13][14][15][16].…”

Section: Purposementioning

confidence: 99%

See 2 more Smart Citations

Chronic cough in postmenopausal women and its associations to climacteric symptoms

Ziller

Oppermann

Cassel

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Chronic cough in postmenopausal women and its associations to climacteric symptoms

et al. 2023

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Background Postmenopausal women often have chronic cough. Hormonal changes might be affecting lung function and the mucous membrane of the airways, causing hypersensitivity of the cough reflex. Therefore, postmenopausal hormonal changes could play a key role in the association between increased cough and menopause. The aim of this study is to evaluate the relation of chronic cough and postmenopausal symptoms. Methods We performed a questionnaire-based cohort study in generally healthy postmenopausal women (age 45–65 years). Women with cough explained by a pre-existing diagnosis were excluded. Comorbidities, medication and baseline data were collected. The Menopause Rating Scale II (MRS II) was combined with the Leicester Cough Questionnaire. Groups were divided in chronic cough versus non-coughing participants, chronic cough was defined as symptoms over 8 weeks. We performed correlations and logistic regression for predicting cough based on postmenopausal symptoms. Results Sixty-six of 200 women (33%) reported symptoms of chronic cough over 8 weeks. No significant differences in baseline data (age, BMI, onset of menopause, years since menopause, concomitant diseases, and medication) were found between coughing and non-coughing women. The MRS II showed higher menopausal symptoms in patients with cough, with significant differences in 2 of the 3 MRS-domains (urogenital (p < 0.001) and somato-vegetative (p < 0.001)). Climacteric symptoms correlated strongly with parameters of cough (p < 0.001). On the basis of the MRS total score (p < 0.001) and the somato-vegetative and urogenital domains (p < 0.05), the prediction for respiratory complaints could be shown. Discussion Chronic cough was significantly associated with menopausal symptoms. Therefore chronic cough as a possible climacteric symptom and its underlying mechanisms should be further explored.

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