Chronisches Lidödem assoziiert mit Rosazea (Morbus Morbihan): Differenzialdiagnostische Schwierigkeiten und Therapieoptionen

Renieri, G.; Brochhausen, Christoph; Pfeiffer, Naomi; Pitz, Susanne

doi:10.1055/s-0029-1245960

Cited by 16 publications

(3 citation statements)

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“…6,10 In cases resistant to mainstay therapies, novel therapies including omalizumab, complex decongestive therapy (CDT), CO 2 blepharoplasty, and surgical eyelid debulking may be used, and have shown some potential for symptomatic improvement. [12][13][14] However among available cases, disease recurrence was noted within 6 months after treatment with CO 2 blepharoplasty and eyelid debulking regimens. 12,15 In two cases of isotretinoin-resistant disease, CDT was documented as providing improvement and later led to symptomatic resolution in one of these cases.…”

Section: Discussionmentioning

confidence: 99%

Morbihan disease: A diagnostic dilemma: two cases with successful resolution

Donthi

Nenow

Samia

et al. 2021

SAGE Open Medical Case Reports

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Morbihan syndrome is a rare entity characterized by persistent erythema and solid edema of upper two-thirds of the face. Although its etiology is poorly understood, it is known to have a wide differential diagnosis and is frequently under-recognized.1–3 We report two such cases of Morbihan syndrome in patients that responded well to treatment with a combination of 2.5% hydrocortisone cream, brimonidine 0.33% topical gel, metronidazole gel and 100 mg doxycycline twice daily. This report emphasizes the necessity of biopsy for clinical correlation in cases of chronic facial edema. It also serves to highlight a potential association of Morbihan syndrome to diabetes mellitus through recently discovered pathophysiology of diabetes on the lymphatic system. It underscores the effectiveness of our therapeutic regimen in the context of other treatment regimen effectiveness. Finally, it highlights novel advances into the diagnosis and treatment of the disease.

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Section: Discussionmentioning

confidence: 99%

Morbihan disease: A diagnostic dilemma: two cases with successful resolution

Donthi

Nenow

Samia

et al. 2021

SAGE Open Medical Case Reports

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“…In the treatment of Morbihan disease, some authors have reported the efficacy of nonsurgical treatment for facial lymphoedema, such as manual lymphatic drainage or compression bandaging 12,13 . Debulking blepharoplasty has often been performed for severe cases, but recurrent swelling is common in the literature 1,4 …”

Section: Discussionmentioning

confidence: 99%

“…9,11 In the treatment of Morbihan disease, some authors have reported the efficacy of nonsurgical treatment for facial lymphoedema, such as manual lymphatic drainage or compression bandaging. 12,13 FIGURE 2. Photograph of LVA.…”

Section: Procedures Simply Debulk Enlarged Tissue Of Lymphoedema To R...mentioning

confidence: 99%

Surgical Lymphoedema Treatment of Morbihan Disease

Hattori¹,

Hino

Niu³

2021

Ann Plast Surg

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Morbihan disease is a rare condition characterized by persistent erythema and solid edema of the upper two thirds of the face, leading to visual impairment and significant esthetic disfigurement. The underlying etiology of the disease remains uncertain, but its correlation with lymphoedema has been conjectured. Definitive treatment options are also lacking, and most current topical, systemic, and surgical interventions provide transient or partial results. In this report, we describe a case of Morbihan disease in a 32-year-old man. He suffered from erythema and swelling over the left periorbital region for 6 years, and was diagnosed with Morbihan disease. As the edema was unresponsive to drug therapy, he was referred to our department. Indocyanine green lymphography was performed, and the diagnosis of facial lymphoedema was confirmed. Manual lymphatic drainage was not effective, so we proceeded with surgical procedures. Lymphaticovenous anastomosis was performed to improve lymphatic drainage, and blepharoplasty was performed to debulk the enlarged tissue of lymphoedema. The visual field improved significantly, and the patient remains free from reexpansion of the lesion during the 1-year follow-up. The surgical approach for lymphoedema treatment can be a viable option for severe Morbihan disease unresponsive to nonsurgical therapies.

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Cutaneous lymphatics and chronic lymphedema of the head and neck

et al. 2011

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Extensive attention has been directed to lymphedema involving the extremities. However, there has been relatively limited study of the cutaneous lymphatics of the head and neck. In this review of head and neck lymphatics, we capsulize the history of the lymphatics, the anatomy of the cutaneous lymphatics, lymphatic function and physiology, and imaging modalities used to define this intricate vascular system. To appreciate the clinical challenges associated with head and neck lymphatic dysfunction, we also provide an overview of disease processes of the cutaneous lymphatics and their treatment, theories on the etiology of lymphedema, and future directions to better understand lymphatic function and disease. Knowledge of the cutaneous lymphatics of the head and neck are critical to the clinical evaluation of patients, who present with this debilitating condition and to our understanding of its pathogenesis and appropriate management.

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Chronisches Lidödem assoziiert mit Rosazea (Morbus Morbihan): Differenzialdiagnostische Schwierigkeiten und Therapieoptionen

Cited by 16 publications

References 0 publications

Morbihan disease: A diagnostic dilemma: two cases with successful resolution

Morbihan disease: A diagnostic dilemma: two cases with successful resolution

Surgical Lymphoedema Treatment of Morbihan Disease

Cutaneous lymphatics and chronic lymphedema of the head and neck

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