Chronopharmacokinetics of Imipenem in the Rat

Boulaméry, Audrey; Kadra, Gais; Simon, Nicolas; Besnard, Thibaud; Bruguerolle, B

doi:10.1080/07420520701648309

Cited by 11 publications

(6 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have reported temporal variations in relevant pharmacokinetic parameters calculated after the administration of various antimicrobial medications, such as norfloxacin (Rebuelto et al, 2003a), ceftriaxone (Rebuelto et al, 2003b), cephalexin (Prados et al, 2007), gentamicin (Widerhon et al, 2005), ciprofloxacin (Sarveshwer Rao et al, 1997), ampicillin (White et al, 1995), ceftibuten (Pan et al, 2003), amikacin (Bleyzac et al, 2000), and imipenem (Boulamery et al, 2007). The results of the present study showed that C max , t max , MRT, λ, t1 2 λ , and AUC calculated after the 08:30 h administration did not differ significantly from those calculated after the 20:30 h administration.…”

Section: Discussionmentioning

confidence: 98%

“…Thus, it is not unexpected that several studies have demonstrated that biological rhythms may influence the pharmacological effects of a variety of medications in animal models (e.g., Dridi et al, 2008) and humans (Bruguerolle, 1998(Bruguerolle, , 2008Smolensky & Peppas, 2007), including antibacterial ones (Beauchamp & Labrecque, 2007;Boulamery et al, 2007;Bruguerolle, 1998;Levi & Schibler, 2007;Ohdo, 2007;Rebuelto, 2006). Chronopharmacology examines the influence of time-of-day on drug pharmacokinetics and pharmacodynamics.…”

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Chronokinetics of Ceftazidime After Intramuscular Administration to Dogs

Monfrinotti

Ambros

Montoya

et al. 2010

Chronobiology International

View full text Add to dashboard Cite

Ceftazidime, a third-generation cephalosporin, is widely used for the treatment of Pseudomonas aeruginosa infections. The aims of the present study were to characterize the pharmacokinetics of ceftazidime and to estimate the T > MIC against P. aeruginosa, after its intramuscular (i.m.) administration at two different dosing times (08:30 h and 20:30 h) to dogs, in order to determine whether time-of-day administration modifies ceftazidime pharmacokinetics and/or predicted clinical antipseudomonal efficacy. Six female healthy beagle dogs were administered ceftazidime pentahydrate by the intramuscular route in a single dose of 25 mg/kg at both 08:30 and 20:30 h, two weeks apart. Plasma ceftazidime concentrations were determined by microbiological assay. Pharmacokinetic parameters and time above the minimum inhibitory concentration (T > MIC) and 4xMIC for Pseudomonas aeruginosa were calculated from the disposition curve of each dog. No differences between the daytime and nighttime administrations were found for the main pharmacokinetic parameters, including C(max), t(max), t((1/2) lambda), AUC, and MRT; however, the high interindividual variability shown by these values and the small number of individuals may account for this lack of difference. Rate of absorption (k(a)) was significantly higher after the 20:30 h than 08:30 h administration. No significant differences between T > MIC were found when comparing the 08:30 h and 20:30 h administrations. Mean T > MIC values predicted a favorable bacteriostatic effect for all susceptible strains of P. aeruginosa for the 12 h dosing interval at both dosing times. Our results suggest that similar antipseudomonal activity may be expected when ceftazidime is administered at 8:30 and 20:30 h; however, as only two timepoints of drug administration were explored, we are unable to draw any conclusions for other treatment times during the 24 h.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 97%

Chronokinetics of Ceftazidime After Intramuscular Administration to Dogs

Monfrinotti

Ambros

Montoya

et al. 2010

Chronobiology International

View full text Add to dashboard Cite

show abstract

“…), timing (in reference to the sleep-wake cycle), and dose/intensity of usual treatments. Research papers pertaining to chronopharmacology-administration time (relative to the sleep-wake, menstrual, or annual cycle) differences in the kinetics and effects of medications-are expected to state the rationale for the choice of the treatment clock times, menstrual days, and months or seasons explored (Boulamery et al, 2007;Bruguerolle, 2008;Hermida et al, 2007;Karakucuk et al, 2006;Smolensky et al, 2007;Yegnanarayan et al, 2006).…”

Section: Chronobiological Criteriamentioning

confidence: 99%

Ethical and Methodological Standards for Laboratory and Medical Biological Rhythm Research

Portaluppi

Touitou

Smolensky

2008

Chronobiology International

316

148

View full text Add to dashboard Cite

The main objectives of this article are to update the ethical standards for the conduct of human and animal biological rhythm research and recommend essential elements for quality chronobiological research information, which should be especially useful for new investigators of the rhythms of life. A secondary objective is to provide for those with an interest in the results of chronobiology investigations, but who might be unfamiliar with the field, an introduction to the basic methods and standards of biological rhythm research and time series data analysis. The journal and its editors endorse compliance of all investigators to the principles of the Declaration of Helsinki of the World Medical Association, which relate to the conduct of ethical research on human beings, and the Guide for the Care and Use of Laboratory Animals of the Institute for Laboratory Animal Research of the National Research Council, which relate to the conduct of ethical research on laboratory and other animals. The editors and the readers of the journal expect the authors of submitted manuscripts to have adhered to the ethical standards dictated by local, national, and international laws and regulations in the conduct of investigations and to be unbiased and accurate in reporting never-before-published research findings. Authors of scientific papers are required to disclose all potential conflicts of interest, particularly when the research is funded in part or in full by the medical and pharmaceutical industry, when the authors are stock-holders of the company that manufactures or markets the products under study, or when the authors are a recent or current paid consultant to the involved company. It is the responsibility of the authors of submitted manuscripts to clearly present sufficient detail about the synchronizer schedule of the studied subjects (i.e., the sleep-wake schedule, ambient light-dark cycle, intensity and spectrum of ambient light exposure, seasons when the research was conducted, shift schedule in studies involving shift work, and menstrual cycle stage in studies involving young women). Rhythm analysis of time series data should be performed with the perspective that rhythms of different periods might be superimposed upon the observed temporal pattern of interest. A variety of different and complementary statistical procedures can be used for rhythm detection. Fitting a mathematical model to the time series data provides a better and more objective analysis of time series data than simple data inspection and narrative description, and if rhythmicity is documented by objective methods, its characterization is required by relevant parameters such as the rhythm's period (tau), MESOR (time series average), amplitude (range of temporal variation), acrophase (time of peak value), and bathyphase (time of trough value). However, the assumptions underlying the time series modeling must be satisfied and applicable in each case, especially the assumption of sinusoidality in the case of cosinor analysis, before it can be accepted...

show abstract

“…Chronomedicine is the study of the chronobiology of health and disease and the translation of applicable findings to clinical medicine (Portaluppi, 2007). In the past few years, in particular, a chronobiological approach has been extensively used in medical research, leading to a better understanding of the pathophysiological mechanisms and features of many medical conditions and public health problems (Burioka et al, 2008;Colognesi et al, 2007;Kawahara et al, 2008;Lee et al, 2008;Leibowitz et al, 2007;Leiza et al, 2007;Lin et al, 2008;Mbanu et al, 2007;Ohkura et al, 2007;Perez-Lloret et al, 2008;Sadick et al, 2007;Sallinen et al, 2008;Shah et al, 2007;Tsai et al, 2007) as well as greater insight of therapeutic issues (Boulamery et al, 2007;Bruguerolle, 2008;Coudert et al, 2008;Dispersyn et al, 2008;Dridi et al, 2008;Hermida, 2007;Hermida et al, 2007bHermida et al, , 2008Prados et al, 2007;Smolensky et al, 2007;Tsuruoka et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Do Restless Legs Syndrome (RLS) and Periodic Limb Movements of Sleep (PLMS) Play a Role in Nocturnal Hypertension and Increased Cardiovascular Risk of Renally Impaired Patients?

Portaluppi¹,

Cortelli

Calandra-Buonaura

et al. 2009

LCBI

View full text Add to dashboard Cite

Hypertension can cause or promote renal failure and is related to cardiovascular mortality, the major cause of death in patients with renal impairment. Changes in the circadian BP pattern, particularly the blunting or reversal of the nocturnal decline in BP, are common in chronic renal failure. These changes in turn are among the major determinants of left ventricular hypertrophy. Using a chronobiological approach, it is possible to obtain better insight into the reciprocal relationship between hypertension, renal disease, and increased cardiovascular risk of renal patients. Disruption of the normal circadian rhythm of rest/activity may be hypothesized to underlie the high cardiovascular morbidity and mortality of such patients. Epidemiological studies reveal that hemodialysis patients experience poor subjective sleep quality and insomnia and, in comparison to healthy persons, are more likely to show shorter sleep duration and lower sleep efficiency. Sleep apnea may be present and is usually investigated in these patients; however, the prevalence of restless legs syndrome (RLS), which is high in dialysis patients and which has been associated with increased risk for cardiovascular disease in the general population, could also play a role in the pathogenesis of sleep-time hypertension in renal patients. Careful assessment of sleep quality, in particular, diagnostic screening for RLS and periodic limb movements (PLM) in renal patients, is highly recommended. In renal failure, attention to sleep quality and related perturbations of the sleep/wake cycle may help prevent the occurrence and progression of cardiovascular disease.

show abstract

Chronopharmacokinetics of Imipenem in the Rat

Cited by 11 publications

References 20 publications

Chronokinetics of Ceftazidime After Intramuscular Administration to Dogs

Chronokinetics of Ceftazidime After Intramuscular Administration to Dogs

Ethical and Methodological Standards for Laboratory and Medical Biological Rhythm Research

Do Restless Legs Syndrome (RLS) and Periodic Limb Movements of Sleep (PLMS) Play a Role in Nocturnal Hypertension and Increased Cardiovascular Risk of Renally Impaired Patients?

Contact Info

Product

Resources

About