ChronOS Inject in Children with Benign Bone Lesions – Does It Increase the Healing Rate?

Joeris, Alexander; Ondruš, Šimon; Plánka, Ladislav; Gál, Petr; Slongo, Theddy

doi:10.1055/s-0029-1241866

Cited by 25 publications

(20 citation statements)

References 10 publications

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“…At a higher pH however, apatite precipitation occurs [7]. Both types of CPC have good biocompatibility and are used clinically [8][9][10][11]. Furthermore, promising in vivo results have been shown for monetite based materials [12].…”

Section: Introductionmentioning

confidence: 99%

Influence of water content on hardening and handling of a premixed calcium phosphate cement

Engstrand

Åberg

Engqvist

2013

Materials Science and Engineering: C

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Section: Introductionmentioning

confidence: 99%

Influence of water content on hardening and handling of a premixed calcium phosphate cement

Engstrand

Åberg

Engqvist

2013

Materials Science and Engineering: C

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“…In our opinion, our promising results as well as the results of the treatment with Grafton ® [42] and ChronOS ® [43] justify a prospective multicenter study for further evaluation.…”

Section: Discussionmentioning

confidence: 90%

“…During follow-up from one to twenty months ten defects were observed with partial or subtotal absorption of the injected cement. The volume injected ranged from 2-30 ml [43]. …”

Section: Discussionmentioning

confidence: 99%

Elastic Stable Intramedullary Nailing (ESIN), Orthoss® and Gravitational Platelet Separation - System (GPS®): An effective method of treatment for pathologic fractures of bone cysts in children

Rapp

Svoboda

Wessel

et al. 2011

BMC Musculoskelet Disord

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BackgroundThe different treatment strategies for bone cysts in children are often associated with persistence and high recurrence rates of the lesions. The safety and clinical outcomes of a combined mechanical and biological treatment with elastic intramedullary nailing, artificial bone substitute and autologous platelet rich plasma are evaluated.MethodsFrom 02/07 to 01/09 we offered all children with bone cysts the treatment combination of elastic intramedullary nailing (ESIN), artificial bone substitute (Orthoss®) and autologous platelet rich plasma, concentrated by the Gravitational Platelet Separation (GPS®) - System. All patients were reviewed radiologically for one year following the removal of the intramedullary nailing, which was possible because of cyst obliteration.ResultsA cohort of 12 children (4 girls, 8 boys) was recruited. The mean patient age was 11.4 years (range 7-15 years). The bone defects (ten humeral, two femoral) included eight juvenile and four aneurysmal bone cysts. Five patients suffered from persistent cysts following earlier unsuccessful treatment of humeral bone cyst after pathologic fracture; the other seven presented with acute pathologic fractures. No peri- or postoperative complications occurred. The radiographic findings showed a total resolution of the cysts in ten cases (Capanna Grade 1); in two cases a small residual cyst remained (Capanna Grade 2). The intramedullary nails were removed six to twelve months (mean 7.7) after the operation; in one case, a fourteen year old boy (Capanna Grade 2), required a further application of GPS® and Orthoss® to reach a total resolution of the cyst. At follow-up (20-41 months, mean 31.8 months) all patients showed very good functional results and had returned to sporting activity. No refracture occurred, no further procedure was necessary.ConclusionsThe combination of elastic intramedullary nailing, artificial bone substitute and autologous platelet rich plasma (GPS®) enhances the treatment of bone cysts in children, with no resulting complications.

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“…This study showed that 80% of patients had a complete or partial response after treatment. Furthermore Joeris et al used percunateous tricalcium sulphate for bone regeneration and concluded that 96% of patients were with good results [71].…”

Section: Coralsmentioning

confidence: 99%

Bone Graft Substitutes for Bone Defect Regeneration. A Collective Review

Kheirallah¹,

Almeshaly²

2016

IJDOS

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Objective: The purpose of this review article is to illustrate the current state of development of bone graft substitutes that could be used for bone defect regeneration, as well as to analyze their efficacy for clinical use. Methods: An electronic search of the PubMed, was performed for articles written in English. The focused question was "ideal graft substitute material to choose in clinical practice"?. The searches were limited to articles including: bone graft, bone defect scaffold, bone substitutes, and bone regeneration. An attempt was made to identify clinical studies. During the data collection, the data were extracted from the studies including scaffold material, properties and advantages of bone substitutes, as well as clinical results if the study has been provided clinically. Results: In spite of several acceptable scaffold options available for bone regeneration, these options still need to bridge the gap between research and clinical practice. There is little information available about the cellular basis for bone regeneration in humans. Several problems limit the broad usage of such options, including lack of randomized controlled human studies, and dubious long term results. Conclusion:The studies should be nurtured and monitored by a combination of clinical experience. Future trends may focus on the effective combinations of osteoinductive materials, osteoinductive growth factors and cell-based tissue regeneration tactics using composite carriers. There is no single ideal graft material to choose in clinical practice, therefore researches are ongoing in all relevant fields, to establish modern bone regeneration protocols that may lead to the innovation of ideal graft substitutes.

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ChronOS Inject in Children with Benign Bone Lesions – Does It Increase the Healing Rate?

Cited by 25 publications

References 10 publications

Influence of water content on hardening and handling of a premixed calcium phosphate cement

Influence of water content on hardening and handling of a premixed calcium phosphate cement

Elastic Stable Intramedullary Nailing (ESIN), Orthoss® and Gravitational Platelet Separation - System (GPS®): An effective method of treatment for pathologic fractures of bone cysts in children

Bone Graft Substitutes for Bone Defect Regeneration. A Collective Review

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