These preliminary results indicate that chronOS Inject could provide an alternative treatment for benign bone cysts that are unlikely to heal spontaneously due to the patient's age, high risk of instability or pathological fracture due to the lesion's size or location, or lesions that have already been treated several times using other methods without success.

The aim of the present study was to assess heavy metal load in the brown bear (Ursus arctos) living in the central European Carpathians. Between 2002 and 2004, fifteen bears were examined to evaluate the distribution of cadmium, lead, mercury and copper in the animals' muscles (diaphragm), spleen, liver and kidney. The highest content of cadmium, lead and mercury was found in the kidney (17.4 ± 5.2 mg·kg -1 , 1.16 ± 0.39 mg·kg -1 , 0.39 ± 0.25 mg·kg -1 ), whereas the lowest content of the metals was observed in the muscles (0.017 ± 0.009 mg·kg -1 , 0.299 ± 0.308 mg·kg -1 , 0.013 ± 0.011 mg·kg -1 ). Second highest concentration of cadmium, lead and mercury was detected in the liver (0.83 ± 0.24 mg·kg -1 , 0.99 ± 0.61mg·kg -1 , 0.11 ± 0.05 mg·kg -1 ). Copper distributions and concentrations in bear tissues were as follows (in descending order): liver (23.9 ± 6.7 mg·kg -1 ), > kidneys (9.0 ± 3.3 mg·kg -1 ), > muscles (1.9 ± 1.6 mg·kg -1 ) and > spleen (1.0 ± 0.2 mg·kg -1 ). As compared with heavy metal load observed in bear tissues between 1988 and 1990, the concentration of cadmium in the muscles and liver was significantly lower (p < 0.01). On the contrary, mercury values were significantly higher in the liver (p < 0.05), kidney and muscle (p < 0.01). Lead and copper tissue concentrations did not change substantially.

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PURPOSE OF THE STUDYTo test the hypothesis that the application of tricalcium phosphate (TCP) mixed with autologous bone marrow can achieve better and faster healing of benign bone lesions than the application of tricalcium phosphate granules alone. MATERIAL AND METHODSThe prospective study included two groups, each consisting of 10 patients, treated for benign cystic bone lesions at the

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