Chronotype and cardio metabolic health in obesity: does nutrition matter?

Muscogiuri, Giovanna; Barrea, Luigi; Framondi, Lydia; Matteo, Rossana Di; Altieri, Barbara; Laudisio, Daniela; Pugliese, Gabriella; Savastano, Silvia; Colao, Annamaria

doi:10.1080/09637486.2021.1885017

Cited by 25 publications

(20 citation statements)

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“…This is especially true in patients with CP and other hypothalamic obesity syndromes, as they are poor responders to dietary and lifestyle modifications [8,[41][42][43] and often show marked weight gain even after forced caloric restriction, suggesting that hyperphagia is not the central problem. Chronotype and circadian rhythms are emerging risk factors of obesity and cardiometabolic diseases [21,22]. Several genes, commonly termed clock genes, represent the molecular mechanism underlying the circadian functions [44].…”

Section: Discussionmentioning

confidence: 99%

“…Of interest, the evening chronotype has a propensity to higher morbidity and mortality compared to the morning chronotype [20]. In particular, individuals with the evening chronotype have a lower adherence towards a healthy diet [21,22] and are more prone to develop obesity and metabolic diseases, such as type 2 diabetes and metabolic syndrome, compared to those with a morning or intermediate chronotype [20,[23][24][25]. Thus, chronotype and circadian rhythms are emerging risk factors of obesity and cardiometabolic diseases [21].…”

Section: Introductionmentioning

confidence: 99%

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Craniopharyngioma, Chronotypes and Metabolic Risk Profile

et al. 2021

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Aim: To investigate the potential association among Craniopharyngioma (CP), chronotypes and metabolic risk profile. Subjects and Methods: The study population included 28 patients (46.4% males; 42.6 ± 15.8 years) and 28 controls, age, gender and BMI matched (46.4% males; 46.5 ± 12.9 years). In this study sample, we evaluated: anthropometric measurements (waist circumference, WC; BMI), plasma glucose, lipid profile, and systolic (SBP) and diastolic (DBP) blood pressure. Morningness-Eveningness was measured with the Horne-Ostberg Morningness-Eveningness Questionnaire (MEQ), which included 19 questions about preferred sleep time and daily performance. Results: in both patients and controls grade I obesity was detected in 15 subjects (53.6%), grade II obesity in 13 subjects (46.4%). In the patient group, the mean score of chronotype was 47.8 ± 12.6. In particular, 9 patients (32.1%) exhibited the morning chronotype, 6 (21.4%) the intermediate chronotype and 13 (46.4.%) the evening chronotype. No significant difference was found in gender and age among the chronotype categories. Patients with the evening chronotype had higher blood pressure values and worse metabolic parameters than those with the morning chronotype. In the control group, the mean score of the chronotype was 57.6 ± 9.5. In particular, 16 (57.1%) subjects exhibited the morning chronotype, 10 (35.7%) the intermediate chronotype and only 2 (7.1.%) the evening chronotype. The prevalence of intermediate and evening chronotypes was higher in females than males (p = 0.021), while males have a higher prevalence of the morning chronotype. Subjects with intermediate and evening chronotypes had worse metabolic parameters than those with the morning chronotype. In patients, the chronotype score was inversely correlated to WC, BMI, SBP, DBP, plasma glucose, total cholesterol, triglycerides, LDL cholesterol and positively correlated with HDL cholesterol. No correlation was found between age and chronotype. In controls, the chronotype score was inversely correlated to WC, BMI, plasma glucose, total cholesterol, LDL cholesterol. No correlation was found among chronotype and age, blood pressure, triglycerides, HDL cholesterol. Considering the whole population of the study (patients and controls), at logistic regression the chronotype score was significantly associated with the presence of CP. Conclusions: for the first time thus far, our study puts the light on the association of the CP with chronotypes and metabolic alterations in this disease, which are the main determinants of the reduced quality of life, higher morbidity and mortality in this setting of patients. This finding suggests that alterations of chronotype might represent an adjunctive risk for CP patients and a possible target for their integrate management.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Craniopharyngioma, Chronotypes and Metabolic Risk Profile

et al. 2021

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“…These findings on the temporal changes in eating behavior of shift workers explain the increased interest in chrononutrition [21,49,50] and chronotypes (i.e., the individual's propensity to early sleep and activity, morningness vs. late sleep and activity, eveningness) [71]. The individual chronotype might also influence the tolerance to shift work and its impact on cardio-metabolic health [36,37,72,73], and eating behavior in the general population [74][75][76]. Gupta et al reviewed the factors influencing the eating behavior of shift workers, highlighting that in addition to food content (the what), the timing of eating (the when), the environment and source of food (the where), and the reasons of eating during the shift (the why) are also part of the eating behavior of shift workers [52].…”

Section: The Impact Of Shift Work On the Timing Of Eatingmentioning

confidence: 92%

The Effects of Shift Work on Cardio-Metabolic Diseases and Eating Patterns

Hemmer¹,

Mareschal²,

Dibner

et al. 2021

Nutrients

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Energy metabolism is tightly linked with circadian rhythms, exposure to ambient light, sleep/wake, fasting/eating, and rest/activity cycles. External factors, such as shift work, lead to a disruption of these rhythms, often called circadian misalignment. Circadian misalignment has an impact on some physiological markers. However, these proxy measurements do not immediately translate into major clinical health outcomes, as shown by later detrimental health effects of shift work and cardio-metabolic disorders. This review focuses on the effects of shift work on circadian rhythms and its implications in cardio-metabolic disorders and eating patterns. Shift work appears to be a risk factor of overweight, obesity, type 2 diabetes, elevated blood pressure, and the metabolic syndrome. However, past studies showed discordant findings regarding the changes of lipid profile and eating patterns. Most studies were either small and short lab studies, or bigger and longer cohort studies, which could not measure health outcomes in a detailed manner. These two designs explain the heterogeneity of shift schedules, occupations, sample size, and methods across studies. Given the burden of non-communicable diseases and the growing concerns about shift workers’ health, novel approaches to study shift work in real contexts are needed and would allow a better understanding of the interlocked risk factors and potential mechanisms involved in the onset of metabolic disorders.

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“…17 This is corroborated by a recent study of 172 middle age adults that showed an increased risk of Type II diabetes and cardiovascular disease in those subjects identified as night owls (evening chronotype). 18 A systematic review of 29 studies looked at parameters of diet quality, dietary patterns and and sleep quality according to self report and objective records. The results showed a clear association between healthy food https://doi.org/10.2147/RMHP.S318698…”

Section: Introductionmentioning

confidence: 99%

“…This is corroborated by a recent study of 172 middle age adults that showed an increased risk of Type II diabetes and cardiovascular disease in those subjects identified as night owls (evening chronotype). 18 …”

Section: Introductionmentioning

confidence: 99%

The Association of Self-Reported Iron and Vitamin D Levels on Sleep Quality and Pain Perception in a Subset of Saudi Population

Al-Khudhairy¹,

AlOtaibi²,

AbdulRahman³

et al. 2021

RMHP

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Background and Aims: There has been a rising concern regarding the relationship of iron levels, vitamin D, and consumption of multivitamins on pain perception and sleep quality. The purpose of this study is to shed light on these connections in hopes of enhancing quality of sleep. Methods: A cross-sectional analysis was used, and data collection was based on closeended online questionnaire created on Survey Monkey. The survey included an operator designed questionnaire, questions from both the Brief Pain Inventory and Sleep Quality questionnaires. The targeted population was participants who were medically fit, nonpregnant Saudi citizens aged between 25 and 55 years. Results: Prior to the COVID-19 crisis, data were collected during the months of February and March 2020, with a grand total of 3127 participants, out of which 2774 responses were included. The outcome of the research revealed that diminished levels of vitamin D, and iron had a negative impact on sleep quality. In turn, poor sleep quality had a significant pain response. Conclusion:This study reveals the detrimental role of vitamins on sleep, and their concurrent domino effect on pain.

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Chronotype and cardio metabolic health in obesity: does nutrition matter?

Cited by 25 publications

References 58 publications

Craniopharyngioma, Chronotypes and Metabolic Risk Profile

Craniopharyngioma, Chronotypes and Metabolic Risk Profile

The Effects of Shift Work on Cardio-Metabolic Diseases and Eating Patterns

The Association of Self-Reported Iron and Vitamin D Levels on Sleep Quality and Pain Perception in a Subset of Saudi Population

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