Chryseobacterium indologenes in a woman with acute leukemia in Senegal: a case report

Abstract

IntroductionThis report documents a rare case of Chryseobacterium indologenes urinary tract infection in Senegal. Chryseobacterium indologenes is an uncommon human pathogen reported in hospital outbreaks in Taiwan and there have been some sporadic cases reported in Europe and in the USA mainly from immune-suppressed patients.Case presentationThis case report describes a 42-year-old woman of Wolofa ethnicity who was hospitalized in our Department of Internal Medicine in a Senegalese university teaching hospital, with acute leukemia who died of severe sepsis 10 days following her hospitalization. A strain of Chryseobacterium indologenes isolated from her urine sample was resistant to several beta-lactams including ampicillin (minimum inhibitory concentrations ≥256μg/mL), cefotaxime (minimum inhibitory concentrations 32μg/mL) and imipenem (minimum inhibitory concentrations ≥32μg/mL), whereas it was susceptible to piperacillin (minimum inhibitory concentrations 16μg/mL), cefepime (minimum inhibitory concentrations 4μg/mL), ceftazidime (minimum inhibitory concentrations 4μg/mL), trimethoprim-sulfamethoxazole (minimum inhibitory concentrations ≤0.25μg/mL) and all tested quinolones including nalidixic acid (minimum inhibitory concentrations ≤2μg/mL).ConclusionsChryseobacterium indologenes although uncommon, is an important pathogen causing infection in hospitalized patients. The management of this infection needs better identification, drug susceptibility testing and monitoring of immunosuppressed patients with long hospitalizations.

Chryseobacterium gleum in a man with prostatectomy in Senegal: a case report and review of the literature

“…Therefore, it was suggested that C. gleum might be less virulent than E. meningoseptica and C. indologenes . In fact, we previously reported a fatal case of urinary tract infection due to C. indologenes in a woman with acute leukemia [8]. This outcome is in contrast to the present case, where the patient survived despite an advanced state of malnutrition.…”

Whole genome sequencing for deciphering the resistome of Chryseobacterium indologenes, an emerging multidrug-resistant bacterium isolated from a cystic fibrosis patient in Marseille, France

“…The first clinical sample of C. indologenes was isolated in 1993 from the tracheal aspirate of a patient with ventilator-associated pneumonia [7] .…”

Chryseobacterium indologenes in four patients with leukemia

“…Therefore, we conclude that the toxicity of C. indologenes was very weak even for the chemotherapy patients, but was lethal for the heavily immunosuppressed patients, such as the post‐alloHSCT patients . Chen et al.…”

“…Chryseobacteria are a group of gram‐negative microbes that cause a variety of infections, usually in patients with respiratory disease or immunosuppression . In 1993, C. indologenes was first isolated from the tracheal aspirate of a patient with ventilator‐associated pneumonia . To the best of our knowledge, infections caused by C. indologenes in hematopoietic stem cell transplanted patients have been reported rarely .…”