Chrysiasis: a gold "curse"!

Localized argyria with pseudo‐ochronosis: A report of two cases highlighting involvement of elastic fibers

“…Silver granules appear microscopically as brown or brownish‐black fine granules deposited along the basement membrane zone of eccrine glands. Chrysiasis from prolonged treatment with gold salts can appear similar; however, only in localized argyria have findings of pseudo‐ochronosis been reported 1–5,7 …”

“…Case 1 also highlights the crucial use of deeper levels, since the focus of pigment may be small and not initially seen in the planes of section, simulating normal skin. Localized argyria can also have a similar appearance to chrysiasis, but the granules from gold deposition tend to be larger, more irregular, and present in a predominantly perivascular distribution 7 …”

“…Chrysiasis from prolonged treatment with gold salts can appear similar; however, only in localized argyria have findings of pseudo-ochronosis been reported. [1][2][3][4][5]7 Ochronosis, either endogenous due to inherited alkaptonuria or exogenous due to the application of topical hydroquinone, results from the accumulation of homogentisic acid. 3,8 The color "ochre" is variable, with red, yellow, orange, purple, or brown tones, as it is a pigment derived from iron-rich rocks that are ground and manipulated into a pigment powder.…”

75-jährige Patientin mit rheumatoider Arthritis und ungewöhnlichem Hautbefund

“…Sie entsteht nach Monaten oder Jahren. Skleren, nicht jedoch die Mundschleimhaut, können betroffen sein[1].…”

Kinetics and mechanism of sodium (Z)-3-(5-chloro-2-((5-chloro-3-(3-sulfonatopropyl) benzothiazol-2(3H)-ylidene)methyl)benzo-thiazol-3-ium-3-yl)propane-1-sulfonate adsorption on gold nanoparticle colloids of different properties and size

“…Iako se koloidno zlato uspešno koristilo kao terapija za reumatoidni artritis kod pacova [4], kod terapije solima zlata primenjene tokom dužeg vremenskog perioda na ljudima, primećena je značajna nuspojava, koja se manifestovala kao svetlo ljubičasto do tamno sivo obojenje kože pri izlaganju suncu [313]. Preterani unos koloidnog zlata i soli zlata tokom krisoterapije rezultuje kompleksnim redoks procesima.…”