Chrysin and other leaf exudate flavonoids in the genus Pelargonium

Williams, Christine A.; Harborne, Jeffrey B.; Newman, Melissa; Greenham, Jenny; Eagles, John M.

doi:10.1016/s0031-9422(97)00514-1

Cited by 109 publications

(68 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar results were reported by Anandhi et al who explained that mushroom extract and chrysin possibly acted by neutralizing the free radicals generated during hypercholesterolemia [27]. The observed increase in MDA in hypercholesterolemic rats is possibly resulted from increased intensity of lipid peroxidation [46,47]. Chrysin significantly increased GSH, CAT, GSH and Cu/Zn SOD levels [48] and has the capability of free radicals scavenging [49].…”

Section: Discussionsupporting

confidence: 79%

Antihypercholesterolemic Effects of Mushroom, Chrysin, Curcumin and Omega-3 in Experimental Hypercholesterolemic Rats

Ismail¹,

Soliman²,

Nassan³

et al. 2015

JFNR

View full text Add to dashboard Cite

Hypercholesterolemia and hypertriglyceridemia are major risk factors that accelerate the incidence of atherosclerosis and coronary artery diseases. Therefore, the present study was conducted to evaluate the hypolipidemic effect of widely known traditional medicinal herbs and omega-3 FA in experimental hypercholesterolemia induced by Triton WR-1339. Experimental hypercholesterolemic rats were administered mushroom, chrysin, curcumin and omega-3 for 2 weeks. Hypercholesterolemic rats showed an increase in serum levels of lipid profiles and hepatic enzymes. Hypercholesterolemic rats showed an increase in malondialdehyde (MDA) levels and a decrease in both serum levels and mRNA expression of catalase, superoxide dismutase (SOD) and glutathione reducatse. Moreover, hypercholesterolemic rats showed hepatic down regulation in the expression of genes related to fatty acids oxidation such as acyl CoA oxidase (ACO) and synthetase (ACS), together with carnityl palmityl transferase-1 (CPT-1) and peroxisome proliferator activator receptor-α (PPAR-α). Administration of mushroom, chrysin, curcumin and omega-3 to hypercholesterolemic rats for 2 weeks up-regulated significantly the down regulated genes. In contrast, expression of genes related to fatty acids biosynthesis and cholesterol metabolism were increased in hypercholesterolemic rats compared to control group. Herbal medications and omega-3 administration down regulated genes of fatty acids biosynthesis and cholesterol metabolism to normal expression. At cellular levels, hyperlipidemia induced fatty droplets accumulation, necrosis and presence of apoptotic hepatocytes together with leukocytic infiltration in necrotic area that are ameliorated and normalized after administration of herbs and omega-3. In conclusion, the current findings indicated that flavonoids (mushroom, chrysin, curcumin) and omega-3 possess antihypercholesterolemic effects at biochemical, molecular and histopathological levels and are useful in treatment of hypercholesterolemia with lower side effects compared with synthetic hypolipidemic drugs.

show abstract

Section: Discussionsupporting

confidence: 79%

Antihypercholesterolemic Effects of Mushroom, Chrysin, Curcumin and Omega-3 in Experimental Hypercholesterolemic Rats

Ismail¹,

Soliman²,

Nassan³

et al. 2015

JFNR

View full text Add to dashboard Cite

show abstract

“…[50,51] It possesses anti-inflammatory, anticancer, anti-allergic, anti-anxiolytic and antioxidant properties, and disturbs cell cycle progression. [52][53][54][55][56] However, the mechanism by which chrysin inhibits cancer cell growth and the intracellular pathways remain poorly understood.…”

Section: Flavonoidsmentioning

confidence: 99%

Cytotoxic constituents of propolis inducing anticancer effects: a review

Watanabe

Amarante

Conti

et al. 2011

Journal of Pharmacy and Pharmacology

190

133

View full text Add to dashboard Cite

Objectives Propolis is a honeybee product used extensively in traditional medicine for its antioxidant, anti-inflammatory, immunomodulatory and anticancer effects. Propolis exhibits a broad spectrum of biological activities because it is a complex mixture of natural substances. In this review, the antitumour effects of propolis extracts and its constituents (e.g. flavonoids, terpenes and caffeic acid phenethyl ester) are discussed. Key findings The effect of propolis on experimental carcinogenesis is discussed, as well as its possible mechanisms of action against tumours, involving apoptosis, cell cycle arrest and interference on metabolic pathways. Propolis seems to be efficient against different tumour cells both in vitro and in vivo, which suggests its potential in the development of new anticancer drugs. Summary Propolis extracts may be important economically and would allow a relatively inexpensive cancer treatment. Preclinical investigations are needed to further elucidate the benefits of propolis and its antitumour properties.

show abstract

“…The flavonoid chrysin (5,7-dihydroxyflavone) is present at high levels in honey and propolis (Siess et al, 1996) and in many plant extracts (Williams et al, 1997). In addition to its reported anticarcinogenic (Cardenas et al, 2006), antiviral (Critchfield et al, 1996), antioxidant (Lapidot et al, 2002), and anti-inflammatory (Cho et al, 2004) activities, chrysin has been shown as a potent inhibitor of aromatase (Jeong et al, 1999), an enzyme responsible for the conversion of androstenedione and testosterone into estrone and estradiol, respectively (Meinhardt and Mullis, 2002).…”

mentioning

confidence: 99%