Chrysin attenuates traumatic brain injury-induced recognition memory decline, and anxiety/depression-like behaviors in rats: Insights into underlying mechanisms

Rashno, Masome; Ghaderi, Shahab; Nesari, Ali; Khorsandi, Layasadat; Farbood, Yaghoob; Sarkaki, Alireza

doi:10.1007/s00213-020-05482-3

Cited by 29 publications

(16 citation statements)

References 67 publications

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“…The flavonoids identified in P. incarnata ( Figure 1 ) probably act according to the pharmacophoric models described. The mechanism of action is probably related to the modulation of the γ -aminobutyric acid (GABA) system, because Passiflora flavonoids are partial agonists of GABA A receptors and inhibit the uptake of [3H]-GABA into rat cortical synaptosomes [ 30 , 67 , 69 , 70 ]. The review article written by Wasowski and Marder [ 58 ] describes flavonoids as GABA A receptor ligands, including apigenin and chrysin that bind to the benzodiazepine-binding site of the GABA A receptor, exhibiting anxiolytic activity, without evidencing sedation and muscle relaxant effects [ 58 , 71 ].…”

Section: Methodsmentioning

confidence: 99%

“…e flavonoids identified in P. incarnata (Figure 1) probably act according to the pharmacophoric models described. e mechanism of action is probably related to the modulation of the c-aminobutyric acid (GABA) system, because Passiflora flavonoids are partial agonists of GABA A receptors and inhibit the uptake of [3H]-GABA into rat cortical synaptosomes [30,67,69,70]. e review article written by Wasowski…”

Section: Mechanism Of Anxiolytic Actionmentioning

confidence: 99%

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Herbal Medicinal Products fromPassiflorafor Anxiety: An Unexploited Potential

Fonseca

Rodrigues

Ramos

et al. 2020

The Scientific World Journal

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Herbal medicines containing Passiflora species have been widely used to treat anxiety since ancient times. The species Passiflora incarnata L. is included in many Pharmacopoeias, and it is the most used species in food, cosmetic, and pharmaceutical industries. However, there are around 600 species of the genus Passiflora and probably other species that can be used safely. Thus, this article was based on a search into the uses of the main species of the genus Passiflora with anxiolytic activity and its main secondary metabolites and some pharmacological studies, patents, and registered products containing Passiflora. Furthermore, the Brazilian Regulatory Health Agency Datavisa, Medicines and Healthcare Products Regulatory Agency of the United Kingdom, and the European Medicines Agency websites were consulted. The results showed that Passiflora species have health benefits but clinical trials are still scarce. The complexity of Passiflora extracts creates challenges for the development of herbal medicines. P. incarnata is the most studied species of the genus and the most used in natural anxiolytic herbal medicine formulations. However, there are hundreds of Passiflora species potentially useful for medicinal and nutraceutical purposes that are still little explored.

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Section: Methodsmentioning

confidence: 99%

Section: Mechanism Of Anxiolytic Actionmentioning

confidence: 99%

Herbal Medicinal Products fromPassiflorafor Anxiety: An Unexploited Potential

Fonseca

Rodrigues

Ramos

et al. 2020

The Scientific World Journal

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“…The inhibitory effect of chrysin on inflammation and oxidative stress is also important in Parkinson’s disease (PD) treatment [ 77 ]. Chrysin (25, 50, and 100 mg/kg) improves cognitive capacity, inflammation, and apoptosis to ameliorate traumatic brain injury (TBI) [ 78 ]. Overall, the literature confirms the health-promoting and therapeutic effects of chrysin that are important in disease therapy, and the effect of this valuable compound on molecular pathways ( Figure 2 ) [ 79 , 80 , 81 , 82 ].…”

Section: Chrysin and Its Pharmacological Activitiesmentioning

confidence: 99%

Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives

et al. 2020

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Pharmacological profile of phytochemicals has attracted much attention to their use in disease therapy. Since cancer is a major problem for public health with high mortality and morbidity worldwide, experiments have focused on revealing the anti-tumor activity of natural products. Flavonoids comprise a large family of natural products with different categories. Chrysin is a hydroxylated flavonoid belonging to the flavone category. Chrysin has demonstrated great potential in treating different disorders, due to possessing biological and therapeutic activities, such as antioxidant, anti-inflammatory, hepatoprotective, neuroprotective, etc. Over recent years, the anti-tumor activity of chrysin has been investigated, and in the present review, we provide a mechanistic discussion of the inhibitory effect of chrysin on proliferation and invasion of different cancer cells. Molecular pathways, such as Notch1, microRNAs, signal transducer and activator of transcription 3 (STAT3), nuclear factor-kappaB (NF-κB), PI3K/Akt, MAPK, etc., as targets of chrysin are discussed. The efficiency of chrysin in promoting anti-tumor activity of chemotherapeutic agents and suppressing drug resistance is described. Moreover, poor bioavailability, as one of the drawbacks of chrysin, is improved using various nanocarriers, such as micelles, polymeric nanoparticles, etc. This updated review will provide a direction for further studies in evaluating the anti-tumor activity of chrysin.

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“…There are various clinical features of TBI, including reduced alertness, attention, memory loss, vison impairment, muscle weakness, etc. Treatment with chrysin was shown to reduce TBI-induced oculomotor dysfunction and memory impairment by inhibiting neuroinflammation and apoptosis via the upregulation of the Bcl-2 family and the downregulation of the Bax protein [62,89]. In another study, chrysin supported the alleviation of TBIrelated anxiety and depression-like behavior.…”

Section: Chrysin In Traumatic and Ischemic Brain Injurymentioning

confidence: 95%

“…In another study, chrysin supported the alleviation of TBIrelated anxiety and depression-like behavior. Furthermore, treatment with chrysin (10 and 20 mg/kg) was demonstrated to reduce brain edema after ischemic stroke [89]. Chrysin further reduced post-ischemic injury by alleviating the expression of pro-inflammatory cytokines (TNF-α and IL-10), as well as reducing pro-apoptotic (Bax) and augmenting anti-apoptotic (Bcl2) protein expression, thus exerting neuroprotective effects [45,89].…”

Section: Chrysin In Traumatic and Ischemic Brain Injurymentioning

confidence: 99%

Neuroprotective Potential of Chrysin: Mechanistic Insights and Therapeutic Potential for Neurological Disorders

Mishra

Bandopadhyay

et al. 2021

Molecules

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Chrysin, a herbal bioactive molecule, exerts a plethora of pharmacological effects, including anti-oxidant, anti-inflammatory, neuroprotective, and anti-cancer. A growing body of evidence has highlighted the emerging role of chrysin in a variety of neurological disorders, including Alzheimer’s and Parkinson’s disease, epilepsy, multiple sclerosis, ischemic stroke, traumatic brain injury, and brain tumors. Based on the results of recent pre-clinical studies and evidence from studies in humans, this review is focused on the molecular mechanisms underlying the neuroprotective effects of chrysin in different neurological diseases. In addition, the potential challenges, and opportunities of chrysin’s inclusion in the neurotherapeutics repertoire are critically discussed.

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Chrysin attenuates traumatic brain injury-induced recognition memory decline, and anxiety/depression-like behaviors in rats: Insights into underlying mechanisms

Cited by 29 publications

References 67 publications

Herbal Medicinal Products fromPassiflorafor Anxiety: An Unexploited Potential

Herbal Medicinal Products fromPassiflorafor Anxiety: An Unexploited Potential

Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives

Neuroprotective Potential of Chrysin: Mechanistic Insights and Therapeutic Potential for Neurological Disorders

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